Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Ausentismo por accidentes y enfermedad laboral y costos indirectos relacionados con la lumbalgia no específica en una entidad prestadora de servicios de salud en Cali 2013.

Labor absenteeism significantly affects the economy and productivity of the company, affects the absentee worker, peers and occupational safety and health management systems.Objective: to describe absenteeism due to medical reasons and indirect costs due to incapacity caused by non-specific low back pain of the workers of a health service provider.Methods: an inductive descriptive study was carried out.Results: It was found that 64.5% of the workers had suffered a work accident and the consequence was a musculoskeletal disorder, and they charged the system with 598 days lost, of which 224 were for non-specific low back pain. The welfare area has the highest absenteeism (60%).Conclusions: The indirect costs for non-specific LBP are high, due to lost time, decreased quality of service, delayed activities, demotivation, nonconformity and workload for non-absent employeesEl ausentismo laboral afecta de manera considerable la economía y la productividad de la empresa, repercute en el trabajador ausente, en sus compañeros y en los sistemas de gestión de seguridad y salud en el trabajo.Objetivo: describir el ausentismo laboral por causa médica y los costos indirectos por incapacidad originado por lumbalgia no específica de los trabajadores de una entidad prestadora de servicios de salud,.Métodos: se realizó un estudio descriptivo inductivo.Resultados: Se encontró que 64.5% de los trabajadores ha sufrido un accidente laboral y cuya consecuencia fue un desorden musculoesqueléticos, y cargaron al sistema 598 días perdidos, de los cuales 224 fueron por lumbalgia no especifica. El área asistencial presenta el mayor ausentismo (60%).Conclusiones: Los costos indirectos por incapacidad por lumbalgia no especifica son altos, por el tiempo perdido, disminución de la calidad del servicio, retardo en las actividades, desmotivación, inconformidad y sobre carga de trabajo para los empleados que no se ausentan