N_c and m_pi dependence of rho and sigma mesons from unitarized Chiral Perturbation Theory

We review our work on the rho and sigma resonances derived from the Inverse Amplitude Method. In particular, we study the leading 1/N_c behavior of the resonances masses and widths and their evolution with changing m_pi. The 1/N_c expansion gives a clear definition of quark-antiquark states, which is neatly satisfied by the rho but not by the sigma, showing that its dominant component is not quark-antiquark. The m_pi dependence of the resonance properties is relevant to connect with lattice studies. We show that our predictions compare well with some lattice results and we find that the rho-pi-pi coupling constant is m_pi independent, in contrast with the sigma-pi-pi coupling, that shows a strong m_pi dependence.Comment: To appear in the Proceedings of the Chiral10 Workshop, June 21-24 2010. Valencia, Spai

Chiral extrapolation of light resonances from one and two-loop unitarized Chiral Perturbation Theory versus lattice results

We study the pion mass dependence of the rho(770) and f_0(600) masses and widths from one and two-loop unitarized Chiral Perturbation Theory. We show the consistency of one-loop calculations with lattice results for the M_rho, f_pi and the isospin 2 scattering length a_20.Then, we develop and apply the modified Inverse Amplitude Method formalism for two-loop ChPT. In contrast to the f_0(600), the rho(770) is rather sensitive to the two-loop ChPT parameters --our main source of systematic uncertainty. We thus provide two-loop unitarized fits constrained by lattice information on M_rho, f_pi, by the qqbar leading 1/N_c behavior of the rho and by existing estimates of low energy constants. These fits yield relatively stable predictions up to m_pi\simeq 300-350 MeV for the rho coupling and width as well as for all the f_0(600) parameters. We confirm, to two-loops, the weak m_pi dependence of the rho coupling and the KSRF relation, and the existence of two virtual f_0(600) poles for sufficiently high m_pi. At two loops one of these poles becomes a bound state when m_pi is somewhat larger than 300 MeV.Comment: 15 pages, to appear in Phys. Rev.

Properties of light resonances from unitarized Chiral perturbation theory: Nc behavior and quark mass dependence

We review the unitarization of Chiral Perturbation Theory with dispersion relations and how it describes meson-meson scattering data, generating light resonances whose mass, width and nature can be related to QCD parameters like quark masses and the number of colors.Comment: Invited review talk for the New Frontiers in QCD 2010, Yukawa International Program for Quark-Hadron Sciences (YIPQS), January 18 (Mon) - March 19 (Fri), 2010 Yukawa Institute for Theoretical Physics, Kyoto, Japan. To appear in Progress of Theoretical Physic

High prevalence of scrapie in a dairy goat herd: tissue distribution of disease-associated PrP and effect of PRNP genotype and age

Following a severe outbreak of clinical scrapie in 2006–2007, a large dairy goat herd was culled and 200 animals were selected for post-mortem examinations in order to ascertain the prevalence of infection, the effect of age, breed and PRNP genotype on the susceptibility to scrapie, the tissue distribution of diseaseassociated PrP (PrP$^{\rm d}$), and the comparative efficiency of different diagnostic methods. As determined by immunohistochemical (IHC) examinations with Bar224 PrP antibody, the prevalence of preclinical infection was very high (72/200; 36.0%), with most infected animals being positive for PrP$^{\rm d}$ in lymphoreticular system (LRS) tissues (68/72; 94.4%) compared to those that were positive in brain samples (38/72; 52.8%). The retropharyngeal lymph node and the palatine tonsil showed the highest frequency of PrP$^{\rm d}$ accumulation (87.3% and 84.5%, respectively), while the recto-anal mucosa-associated lymphoid tissue (RAMALT) was positive in only 30 (41.7%) of the infected goats. However, the efficiency of rectal and palatine tonsil biopsies taken shortly before necropsy was similar. The probability of brain and RAMALT being positive directly correlated with the spread of PrP$^{\rm d}$ within the LRS. The prevalence of infection was influenced by PRNP genetics at codon 142 and by the age of the goats: methionine carriers older than 60 months showed a much lower prevalence of infection (12/78; 15.4%) than those younger than 60 months (20/42; 47.6%); these last showed prevalence values similar to isoleucine homozygotes of any age (40/80; 50.0%). Two of seven goats with definite signs of scrapie were negative for PrP$^{\rm d}$ in brain but positive in LRS tissues, and one goat showed biochemical and IHC features of PrP$^{\rm d}$ different from all other infected goats. The results of this study have implications for surveillance and control policies for scrapie in goats

Dynamical study of the light scalar mesons below 1 GeV in a flux-tube model

The light scalar mesons below 1 GeV as tetraquark states are studied in the framework of the flux-tube model, the multi-body confinement instead of the additive two-body confinement is used. From the calculated results, we find that the light scalar mesons, $\sigma$, $\kappa$ could be well accommodated in the diquark-antidiquark tetraquark picture in the flux-tube model and they could be color confinement resonances. The mass of the first radial excited state of $[ud][\bar{u}\bar{d}]$ is 1019 MeV, which is close to the mass of $f_0(980)$. Whereas $a_0(980)$ can not be fitted in this interpretation.Comment: 11 pages, 1 figur

Mobile Personal Healthcare System for Non-Invasive, Pervasive and Continuous Blood Pressure Monitoring: A Feasibility Study

Background: Smartphone-based blood pressure (BP) monitor using photoplethysmogram (PPG) technology has emerged as a promising approach to empower users with self-monitoring for effective diagnosis and control ofhypertension (HT). Objective: This study aimed to develop a mobile personal healthcare system for non-invasive, pervasive, and continuous estimation of BP level and variability to be user-friendly to elderly. Methods: The proposed approach was integrated by a self-designed cuffless, calibration-free, wireless and wearable PPG-only sensor, and a native purposely-designed smartphone application using multilayer perceptron machine learning techniques from raw signals. We performed a pilot study with three elder adults (mean age 61.3 ± 1.5 years; 66% women) to test usability and accuracy of the smartphone-based BP monitor. Results: The employed artificial neural network (ANN) model performed with high accuracy in terms of predicting the reference BP values of our validation sample (n=150). On average, our approach predicted BP measures with accuracy \u3e90% and correlations \u3e0.90 (P \u3c .0001). Bland-Altman plots showed that most of the errors for BP prediction were less than 10 mmHg. Conclusions: With further development and validation, the proposed system could provide a cost-effective strategy to improve the quality and coverage of healthcare, particularly in rural zones, areas lacking physicians, and solitary elderly populations