Monoballism Associated with Newly Onset Ketotic Hyperglycemia

Movement disorders as the initial symptoms of diabetes mellitus are rare. Here, we describe one of these rare manifestations of primary diabetes: a case of newly diagnosed diabetes mellitus in an old-age female patient with transient monoballismus during an episode of ketotic hyperglycemia

The Effect of Age at Diagnosis on Mortality in ANCA-Associated Vasculitides

WOS: 00044726890505

Serum magnesium levels in patients with the necrotizing and edematous types of acute pancreatitis with and Without hypocalcemia

Objective: We aimed to investigate the association of serum magnesium levels with the disease state in patients having necrotizing and edematous types of acute pancreatitis with or without hypocalcemia.Methods: the hospital records of 114 patients, meeting the criteria of the revised Atlanta classification of acute pancreatitis were evaluated retrospectively for their serum magnesium, calcium, albumin and C-reactive protein (CRP) levels and leukocyte and platelet counts. Results: Mean age of the patients was 58.9±15 years. Serum magnesium, calcium and albumin levels were significantly lower in patients with acute necrotizing pancreatitis than those of the cases with the edematous type (1.85±0.6 mg/dL vs. 2.12±0.26 mg/dL; p;lt;0.001, 8.37±0.51 mg/dL vs. 8.86±0.59 mg/dL; p;lt;0.001 and 3.34 g/dL±0.67 g/dL vs. 3.75±0.46 g/dL; p=0.003, respectively). Patients with hypocalcemia had lower levels of serum magnesium, and higher levels of serum CRP and leucocyte counts when compared with the patients without hypocalcemia (p;lt;0.001, p=0.002 and p=0.002, respectively). According to the type of disease, the number of patients with advanced age increased 1.047-fold (CI: 1.006-1.089; p=0.025), normal levels of serum magnesium increased 45.4-fold (CI: 3.548-582.336; p=0.003) in patients with the edematous type, and, high levels of serum CRP increased 1.082-fold (CI: 1.017-1.157; p=0.013) in patients with the acute necrotizing pancreatitis. After the disease severity was taken under control , serum magnesium levels were found to be moderately correlated with the serum albumin levels (r=0.32; p;lt;0.001).Conclusion: Although patients with acute necrotizing pancreatitis and hypocalcemia revealed low levels of serum magnesium, hypomagnesemia was not associated with the disease severity in patients with acute pancreatitis.Amaç: Nekrotizan ve ödematöz tip akut pankreatitli, hipokalsemisi olan ve olmayan hastaların serum magnezyum düzeylerinin hastalık ile ilişkisini incelemeyi amaçladık.Yöntem: Akut pankreatit için revize edilmiş Atlanta kriterlerini karşılayan 114 hastanın hastane kayıtlarından geriye dönük olarak serum magnezyum, kalsiyum, albumin, C-reaktif protein düzeyleri ile lökosit ve trombosit sayıları değerlendirildi.Bulgular: Yaş ortalaması 58,9±15 yıldı. Serum magnezyum, kalsiyum ve albumin düzeyleri nekrotizan tip akut pankreatitli hastalarımızda ödematöz tipteki akut pankreatitli hastalarımıza göre anlamlı derecede düşüktü. Sırasıyla (1,85±0,6 mg/dL vb. 2,12±0,26 mg/dL; p0,001, 8,37±0,51 mg/dL vb. 8,86±0,59 mg/dL; p0,001 ve 3,34 g/dL±0,67 g/dL vb. 3,75±0,46 g/dL; p=0,003). Tüm hasta grubunda hipokalsemi saptananlarda saptanmayanlara göre serum magnezyum düzeyleri düşük, serum CRP düzeyleri ve lökosit sayıları yüksek bulundu. Sırasıyla (p0,001; p=0,002 ve p=0,002). Hastalık tipine göre yapılan değerlendirmede, ödematöz tip akut pankreatitli hastalarda ileri yaşın 1,047-kat (CI: 1,006-1,089; p=0,025), normal düzeylerdeki serum magezyumun 45,4-kat (CI: 3,548-582,336; p=0,003), nekrotizan tip akut pankreatitli hastalarda yüksek serum CRP düzeylerinin 1,082-kat (CI: 1,017-1,157; p=0,013) daha fazla görüldüğü saptandı. Hastalık şiddeti kontrol altına alındıktan sonra serum magnezyum ile albumin düzeylerinin orta düzeyde (r=0,32; p0,001) ilişkili olduğu saptandı.Sonuç: Nekrotizan tip akut pankreatitli ve hipokalsemisi olan hastalarımızda serum magnezyum düzeyleri düşük bulunsa da akut pankreatitte hipomagnezeminin hastalık şiddeti ile ilişkisi bulunamadı