Design and synthesis of a potential BNCT agent capable of photodynamic therapy

Bor nötron yakalama terapisi çeşitli kanser hastalıklarının özellikle beyin tümörleri ve melanom kanserlerinin tedavisinde kullanılmak üzere geliştirilen etkili bir tedavi yöntemidir. Bu tez çalışmasında fotodinamik terapi yapabilen potansiyel bir bor nötron yakalama terapisi ajanının tasarımı ve sentezi amaçlanmıştır. Bu amaçla öncelikle polihedral bor bileşikleri ve siyanin boyaları rasyonel bir tasarımla bir araya getirilerek yeni nesil teranostik bir ajan ortaya konmuştur. Tasarımı ve sentezi gerçekleştirilen bu yeni bileşiğin yapısal karakterizasyonu, fotodinamik terapi yapabilme yeteneği morötesi ve görünür ışık (UV-Vis) ve emisyon (yayınma) spektroskopisi, hidrojen çekirdek magnetik rezonans spektroskopisi (1H NMR) ve karbon çekirdek magnetik rezonans spektroskopisi (13C NMR) gibi yöntemler kullanılarak aydınlatılmıştır.Boron neutron capture therapy is an effective treatment method developed for the treatment of various cancer diseases, especially brain tumors and melanoma cancers. In this thesis, the design and synthesis of a potential boron neutron capture therapy agent capable of photodynamic therapy were aimed. For this purpose, first of all, a new generation theranostic agent was created by combining polyhedral boron compounds and cyanine dyes with a rational design. Structural characterization of this new compound designed and synthesized, its ability to perform photodynamic therapy, ultraviolet and visible light (UV-Vis) and emission (emissivity) spectroscopy, hydrogen core magnetic resonance spectroscopy (1H NMR) and carbon core magnetic resonance spectroscopy (13C NMR) elucidated using method

A generic platform for self-illuminating unimolecular systems enabling photodynamic therapy

This work delineates a generic platform, 1-((1,4-dioxo-1,2,3,4-tetrahydrophthalazin-6-yl)methyl)-1H-1,2,3-triazol-4-yl)methyl 2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoate, (conjugate 1), for self-illuminating unimolecular systems that can both glow in physiological pH (7.4) and enable photodynamic therapy (PDT) in highly acidic environments. It is noteworthy that conjugate 1 induces chemiluminescence upon treatment with KO2 at physiological pH. Also, it is remarkable that this straightforward design effectively boosts the singlet oxygen generation. Most strikingly, conjugate 1 can function as a photosensitizer even in highly acidic environments. Crucially, conjugate 1 shows in vitro phototoxicity when illuminated for 30 min. Furthermore, the capability of conjugate 1 as a self-illuminating PDT agent is explored. To our delight, we noted that conjugate 1 can eliminate 79% of cancerous cells upon chemical excitation being triggered in vitro. The data render its efficiency as a self-illuminating anticancer therapy agent. Last but not least, conjugate 1 can successfully inhibit the growth of bacteria. Also, we found that the shelf life of the acidic beverages can be extended from 2 days to ≅ 6–7 days after photodynamic sterilization with conjugate 1. To our best knowledge, this is the first example of luminol-based self-illuminating unimolecular systems enabling PDT for anticancer and antibacterial activities