The β-modification of trizinc borate phosphate, Zn3(BO3)(PO4)

Crystals of β-Zn3(BO3)(PO4) have been grown by the Kyropoulos method. The asymmetric unit contains three Zn sites, three B-atom sites (all with symmetry 3), two P sites (both with m symmetry) and nine O-atom sites (four with m symmetry). The fundamental building units of the title structure are isolated BO3 triangles and PO4 tetra­hedra, which are bridged by ZnO4 tetra­hedra or ZnO5 trigonal bipyramids through common O atoms, leading to a three-dimensional framework structure. Some significant structural differences between the β-polymorph and the α-polymorph are discussed

Nonapotassium trialuminium hexa­phosphate

In the title compound, K9Al3(PO4)6, the anionic substructure is built of inter­linked [PO4] and [AlO4] tetra­hedra. Each O atom of the [AlO4] tetra­hedron is common to a positionally different [PO4] tetra­hedron; thus, each [AlO4] tetra­hedron is surrounded by four positionally different [PO4] tetra­hedra. On the other hand, each [PO4] tetra­hedron shares its two O atoms with two positionally different [AlO4] tetra­hedra; the other two phosphate O atoms are terminal ones coordinated by K atoms. The terminal O atoms are usually closer to the K atoms than the bridging O atoms between the [AlO4] and [PO4] tetra­hedra. There are nine symmetry-independent K atoms in the structure. The coordination numbers of the K atoms are 6 or 7 or 8 up to a distance of 3.31 Å. There are channels in the anionic substructure oriented along the [10] direction that are filled by K atoms

The Proliferation Enhancing Effects of Salidroside on Schwann Cells In Vitro

Derived from Rhodiola rosea L., which is a popular plant in Eastern Europe and Asia, salidroside has pharmacological properties including antiviral, anticancer, hepatoprotective, antidiabetic, and antioxidative effects. Recent studies show that salidroside has neurotrophic and neuroprotective effects. However, the effect of salidroside on Schwann cells (SCs) and the underlying mechanisms of the salidroside-induced neurotrophin secretion have seldom been studied. In this study, the effect of salidroside on the survival, proliferation, and gene expression of Schwann cells lineage (RSC96) was studied through the examinations of the cell viability, proliferation, morphology, and expression of neurotrophic factor related genes including BDNF, GDNF, and CDNF at 2, 4, and 6 days, respectively. These results showed that salidroside significantly enhanced survival and proliferation of SCs. The underlying mechanism might involve that salidroside affected SCs growth through the modulation of several neurotrophic factors including BDNF, GDNF, and CDNF. As for the concentration, 0.4 mM, 0.2 mM, and 0.1 mM of salidroside were recommended, especially 0.2 mM. This investigation indicates that salidroside is capable of enhancing SCs survival and function in vitro, which highlights the possibility that salidroside as a drug agent to promote nerve regeneration in cellular nerve scaffold through salidroside-induced neurotrophin secretion in SCs

Book Reviews and the Consolidation of Genre

Some literary scholars have claimed that predictive models can measure the strength of the boundaries that separate different cultural categories—genres, for instance, or market segments. But interpreting textual models as evidence about the strength of a cultural distinction has seemed a questionable move to many readers. We use book reviews to test this inference. Are the similarities between fictional texts purely verbal phenomena, or do they reflect social categories that are also legible (although expressed differently) in readers' responses to those texts? We find that the subject and genre categories most strongly marked in fictional texts are also the categories most strongly marked in reviews of fiction. The correlation is strong; r > .8

Optimizing Peer Distribution of Syphilis Self-Testing Among Men Who Have Sex with Men in China: A Multi-City Pragmatic Randomized Controlled Trial

Syphilis testing uptake is low among men who have sex with men (MSM) around the world. Syphilis self-testing (SST) may complement facility-based testing; the distribution model is yet to be explored. This study aimed to investigate the effectiveness of peer distribution of syphilis self-testing on promoting syphilis testing. We conducted a three-arm, unblinded, parallel individually randomized controlled trial among MSM in three cities in Guangdong, China. Inclusion criteria were: men who were born biologically male, aged 18 or above, have ever had sex with a man, will refer the interventions to peers, and will take the three-month follow-up survey. Enrolled indexes were randomly assigned in a 1:1:1 ratio into standard-of-care arm (SOC arm), standard SST delivery arm (S-SST arm), and a web-based referral link SST delivery arm (RL-SST arm). The primary outcome was the number of returned photograph-verified syphilis testing results per index. A total number of 300 indexes were enrolled, with 100 indexes in each arm. The number of verified syphilis tests per index conducted by alters was 0.05 in the control arm, 0.51 in the S-SST arm, and 0.31 in the RL-SST arm. The cost per alter tested was $760.60 for SOC,$83.78 for S-SST, and $93.10 for RL-SST. Minimal adverse event was reported among both indexes and alters during the study. This study showed that peer distribution of SST could improve syphilis testing uptake among MSM in China compared to facility-based testing. This approach warrants further consideration as part of expanding syphilis self-testing

Increased Functional Brain Network Efficiency During Audiovisual Temporal Asynchrony Integration Task in Aging

Audiovisual integration significantly changes over the lifespan, but age-related functional connectivity in audiovisual temporal asynchrony integration tasks remains underexplored. In the present study, electroencephalograms (EEGs) of 27 young adults (22–25 years) and 25 old adults (61–76 years) were recorded during an audiovisual temporal asynchrony integration task with seven conditions [auditory (A), visual (V), AV, A50V, A100V, V50A and V100A]. We calculated the phase lag index (PLI)-weighted connectivity networks modulated by the audiovisual tasks and found that the PLI connections showed obvious dynamic changes after stimulus onset. In the theta (4–7 Hz) and alpha (8–13 Hz) bands, the AV and V50A conditions induced stronger functional connections and higher global and local efficiencies, reflecting a stronger audiovisual integration effect, which was attributed to the auditory information arriving at the primary auditory cortex earlier than the visual information reaching the primary visual cortex. Importantly, the functional connectivity and network efficiencies of old adults revealed higher global and local efficiencies and higher degree in both the theta and alpha bands. These larger network efficiencies indicated that old adults might experience more difficulties in attention and cognitive control during the audiovisual integration task with temporal asynchrony than young adults. There were significant associations between network efficiencies and peak time of integration only in young adults. We propose that an audiovisual task with multiple conditions might arouse the appropriate attention in young adults but would lead to a ceiling effect in old adults. Our findings provide new insights into the network topography of old adults during audiovisual integration and highlight higher functional connectivity and network efficiencies due to greater cognitive demand

Associations of Amylin with Inflammatory Markers and Metabolic Syndrome in Apparently Healthy Chinese

BACKGROUND: Cellular and animal studies implicate multiple roles of amylin in regulating insulin action, glucose and lipid metabolisms. However, the role of amylin in obesity related metabolic disorders has not been thoroughly investigated in humans. Therefore, we aimed to evaluate the distribution of circulating amylin and its association with metabolic syndrome (MetS) and explore if this association is influenced by obesity, inflammatory markers or insulin resistance in apparently healthy Chinese. METHODS: A population-based sample of 1,011 Chinese men and women aged 35-54 years was employed to measure plasma amylin, inflammatory markers (C-reactive protein [CRP] and interleukin-6 [IL-6]), insulin, glucose and lipid profiles. MetS was defined according to the updated National Cholesterol Education Program Adult Treatment Panel III criteria for Asian-Americans. RESULTS: Plasma amylin concentrations were higher in overweight/obese participants than normal-weight counterparts (P<0.001) without sex difference. Circulating amylin was positively associated with CRP, IL-6, BMI, waist circumference, blood pressure, fasting glucose, insulin, amylin/insulin ratio, HOMA-IR, LDL cholesterol and triglycerides, while negatively associated with HDL cholesterol (all P<0.001). After multiple adjustments, the risk of MetS was significantly higher (odds ratio 3.71; 95% confidence interval: 2.53 to 5.46) comparing the highest with the lowest amylin quartile. The association remained significant even further controlling for BMI, inflammatory markers, insulin or HOMA-IR. CONCLUSIONS: Our study suggests that amylin is strongly associated with inflammatory markers and MetS. The amylin-MetS association is independent of established risk factors of MetS, including obesity, inflammatory markers and insulin resistance. The causal role of hyperamylinemia in the development of MetS needs to be confirmed prospectively

Teaching trans studies through fan fiction in college English classrooms

Trans studies has usually been taught within gender studies and women's studies programs. Yet, as trans studies has become highly interdisciplinary, trans awareness is still an issue in many fields; thus, incorporating trans discussions in courses in multiple disciplines is imperative. This study demonstrates how the firsthand teaching experience of a student-centered, literary-theory-related undergraduate course unit given by the English department incorporated trans studies through fan fiction. Particularly, we utilized the theoretical concept of nonbinary genders and its resistance to the heteronormative and heteropatriarchal system via a study of Loki's gender fluidity in the Loki miniseries, some exemplary transgender fan fiction, and the Omegaverse. Fandoms and fan fiction can be valuable course materials to create a comfortable space for students from different backgrounds to actively engage, discuss, and think critically about trans topics and trans theories. In this sense, this course unit explores the possibility of teaching trans studies beyond gender studies classrooms as well as courses focusing primarily on trans studies, encouraging more students to understand trans concepts and become trans allies

Culture and political regimes: How have they influenced the effectiveness of COVID-19 response policy?

This study investigates the efficacy of national emergency response policies in addressing the COVID-19 pandemic and their interactions with cultural and political factors. Employing the synthetic control method, we analyze data from countries on five continents that implemented such policies in early 2020. Our results indicate the overall effectiveness of these policies in mitigating the impact of COVID-19 yet reveal significant variability in their outcomes among countries. Notably, we identify a negative association between policy effectiveness and a culture characterized by individualism. Additionally, we observe that the impact of COVID-19 response measures is more prominent in countries with lower levels of democracy. These findings offer valuable insights into the intricate interplay between COVID-19 response policies, cultural dynamics, and political regimes, with potential implications for future policy decisions and research endeavors