Near-Fault Ground Motion Influence on the Seismic Responses of a Structure with Viscous Dampers considering SSI Effect

This paper studies the influence of the characteristics of the near-fault ground motion on the seismic responses of the structure with energy dissipation devices including soil-structure interaction (SSI). A ten-story reinforced concrete frame rested on soft site is introduced, and the viscous dampers added in the frame are designed. The numerical analysis method of the soil-structure system with viscous dampers is established through ANSYS program. In addition, the response spectra of the main characteristics of the near-fault ground motion, like hanging wall effect, velocity pulse-like effect, and forward-directivity effect, are investigated carefully to learn the features of spectra energy distribution. And then, the dynamic time-history analysis is performed on the SSI system with and without viscous dampers subjected to the selected near-fault ground motion. The study reveals that the seismic responses of the structure subjected to near-fault ground motion with hanging wall effect are obviously larger than those of the footwall effect, indicating the distinct hanging wall effects on the structural dynamic responses. In addition, the performance of the structure with viscous dampers is more influenced by the ground motion containing fling-step effect than that with forward-directivity effect. Moreover, the influence of the horizontal component of forward-directivity ground motion on the seismic responses of the structure is more obvious than that of parallel component ground motion. Consequently, the hanging wall effect, velocity pulse, and horizontal component in forward-directivity effect of the near-fault ground motion have distinct influence on the seismic responses of the structure with energy dissipation devices considering SSI effect, providing insight towards the performance-based seismic design of buildings rested at the near-fault sites considering the seismic SSI effect

Local and Global Feature Aggregation-Aware Network for Salient Object Detection

With the rise of deep learning technology, salient object detection algorithms based on convolutional neural networks (CNNs) are gradually replacing traditional methods. The majority of existing studies, however, focused on the integration of multi-scale features, thereby ignoring the characteristics of other significant features. To address this problem, we fully utilized the features to alleviate redundancy. In this paper, a novel CNN named local and global feature aggregation-aware network (LGFAN) has been proposed. It is a combination of the visual geometry group backbone for feature extraction, an attention module for high-quality feature filtering, and an aggregation module with a mechanism for rich salient features to ease the dilution process on the top-down pathway. Experimental results on five public datasets demonstrated that the proposed method improves computational efficiency while maintaining favorable performance

Molecular Cloning, Promoter Analysis and Expression Profiles of the sox3 Gene in Japanese Flounder, Paralichthys olivaceus

Sox3, which belongs to the SoxB1 subgroup, plays major roles in neural and gonadal development. In the present study, Japanese flounder Paralichthys olivaceus sox3 gene (Posox3) and its promoter sequence were isolated and characterized. The deduced PoSox3 protein contained 298 amino acids with a characteristic HMG-box domain. Alignment and phylogenetic analyses indicated that PoSox3 shares highly identical sequence with Sox3 homologues from different species. The promoter region of Posox3 has many potential transcription factor (TF) binding sites. The expression profiles of Posox3 in different developmental stages and diverse adult tissues were analyzed by quantitative real-time RT-PCR (qRT-PCR). Posox3 mRNA was maternally inherited, and maintained at a considerably high expression level between the blastula stage and the hatching stage during embryonic development. Posox3 was abundantly expressed in the adult brain and showed sexually dimorphic expression pattern. In situ hybridization (ISH) was carried out to investigate the cellular distribution of Posox3 in the ovary, and results showed the uniform distribution of Posox3 throughout the cytoplasm of oogonia and stage I–III oocytes. These results indicate that Posox3 has potentially vital roles in embryonic and neural development and may be involved in the oogenesis process. Our work provides a fundamental understanding of the structure and potential functions of Sox3 in Paralichthys olivaceus

Development of an efficient yeast platform for cannabigerolic acid biosynthesis

Cannabinoids are important therapeutical molecules for human ailments, cancer treatment, and SARS-CoV-2. The central cannabinoid, cannabigerolic acid (CBGA), is generated from geranyl pyrophosphate and olivetolic acid by Cannabis sativa prenyltransferase (CsPT4). Despite efforts to engineer microorganisms such as Saccharomyces cerevisiae (S. cerevisiae) for CBGA production, their titers remain suboptimal because of the low conversion of hexanoate into olivetolic acid and the limited activity and stability of the CsPT4. To address the low hexanoate conversion, we eliminated hexanoate consumption by the beta-oxidation pathway and reduced its incorporation into fatty acids. To address CsPT4 limitations, we expanded the endoplasmic reticulum and fused an auxiliary protein to CsPT4. Consequently, the engineered S. cerevisiae chassis showed a marked improvement of 78.64-fold in CBGA production, reaching a titer of 510.32 ± 10.70 mg l−1 from glucose and hexanoate

Health Assessment of Trace Metal Concentrations in Organic Fertilizer in Northern China

The application of organic fertilizer could be accompanied by potential hazards to soil and humans caused by trace metals. A wide survey of organic fertilizers was carried out in northern China. A total of 117 organic fertilizer samples were collected to analyze the concentrations of seven trace metals. Simulation models were used to estimate the trace metal accumulation risk in soil and non-carcinogenic and carcinogenic risks to the human body. The concentrations of trace metals varied widely (Cr: 2.74–151.15; Ni: 2.94–49.35; Cu: 0.76–378.32; Zn: 0.50–1748.01; As: 1.54–23.96; Cd: 2.74–151.15; and Pb: 1.60–151.09 mg·kg−1). Chinese organic fertilizer standard limits were exceeded by0.85% for Cr, 5.98% for As, 1.71% for Cd, and 4.27% for Pb. Monte Carlo simulations showed that repeated application of organic fertilizer likely significantly increased the concentrations of Zn, Cd, and As in soil compared with the soil background levels according to the Soil Environmental Quality Standards of China. As and Cr pose high risks to human health, especially as carcinogenic risk factors with a skin exposure pathway. Reducing the content of Cr, Cu, Zn, As, and Cd in organic fertilizer would be of great significance for minimizing the damage caused by trace metals

Supplementary document for Stretch tuning of dispersion in optical microfibers - 6722629.pdf

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