Synthesis and anticancer evaluation of new disulfides incorporating naphthalimide moiety

A series of new disulfides incorporating naphthalimide moiety were designed, synthesized and biologically evaluated against three human cancer cell lines (MCF-7, SMMC-7721 and Hela). Most of target compounds exhibited some degrees of anticancer activities, and some compounds displayed better effects than reference drugs PX-12 and 5-FU against the tested three cancer cells. Especially, compound 7d showed the most potent antiproliferative activity against MCF-7 cell lines with IC50 value of 3.19 μM. Compound 8a displayed prominent anticancer property against SMMC-7721 cell lines with IC50 value of 1.84 μM. Compound 6c possessed the most effective proliferation inhibitory activity against Hela cell lines with IC50 value of 2.14 μM. In addition, cytotoxicity evaluation indicated that most of the compounds had weak cytotoxicity to L929 cell lines.</p

Novel Metal–Organic Framework Based on Cubic and Trisoctahedral Supermolecular Building Blocks: Topological Analysis and Photoluminescent Property

A novel supermolecular building blocks (SBBs) based metal–organic framework (MOF), with formula [Zn₇(TMBHB)₂·2NO₃·5DMF·4CH₃CH₂OH·6H₂O]_<i>n</i> (<b>SDU-1</b>), was constructed from <i>C</i>₃-symmetric trimethyl substituted 3,3′,3″,5,5′,5″-benzene-1,3,5-triylhexabenzoic acid (H₆TMBHB). Notably, the <b>SDU-1</b> consists of two kinds of rare secondary building units (SBUs), [Zn₂(COO)₃] and [Zn₂(COO)₄], which are linked by TMBHB to form cubic and trisoctahedral SBBs, respectively. TOPOS software analysis of <b>SDU-1</b> indicates that two alternative simplifications based on different SBBs can produce (3,24)-connected <b>rht</b> or (4,12)-connected <b>ftw</b> topologies. Compared with a recently reported Zn-BHB (H₆BHB = 3,3′,3″,5,5′,5″-benzene-1,3,5-triylhexabenzoic acid) MOF, the structural dissimilarity between them was caused by the steric hindrance of three methyl groups, which makes three isophthalate units on TMBHB nearly perpendicular to the central phenyl ring, giving TMBHB a nonplanar conformation. The photoluminescence behavior of <b>SDU-1</b> was also discussed

Novel Metal–Organic Framework Based on Cubic and Trisoctahedral Supermolecular Building Blocks: Topological Analysis and Photoluminescent Property

A novel supermolecular building blocks (SBBs) based metal–organic framework (MOF), with formula [Zn₇(TMBHB)₂·2NO₃·5DMF·4CH₃CH₂OH·6H₂O]_<i>n</i> (<b>SDU-1</b>), was constructed from <i>C</i>₃-symmetric trimethyl substituted 3,3′,3″,5,5′,5″-benzene-1,3,5-triylhexabenzoic acid (H₆TMBHB). Notably, the <b>SDU-1</b> consists of two kinds of rare secondary building units (SBUs), [Zn₂(COO)₃] and [Zn₂(COO)₄], which are linked by TMBHB to form cubic and trisoctahedral SBBs, respectively. TOPOS software analysis of <b>SDU-1</b> indicates that two alternative simplifications based on different SBBs can produce (3,24)-connected <b>rht</b> or (4,12)-connected <b>ftw</b> topologies. Compared with a recently reported Zn-BHB (H₆BHB = 3,3′,3″,5,5′,5″-benzene-1,3,5-triylhexabenzoic acid) MOF, the structural dissimilarity between them was caused by the steric hindrance of three methyl groups, which makes three isophthalate units on TMBHB nearly perpendicular to the central phenyl ring, giving TMBHB a nonplanar conformation. The photoluminescence behavior of <b>SDU-1</b> was also discussed