Study of Word-Level Accent Classification and Gender Factors

Abstract In this work, we conduct word-level accent classification. Different features, words, and learning methods are explored for accent classification, and results show that HMM-MFCC models show promising performance. Besides, we also explore the effect of gender on accent classification. Results show that models trained on male data do not generalized well on female data; Models trained on both male and female data is not always better than models trained on female data only. At last, we propose to use stacked ensemble classifier to classify gender firstly and then classify accent to improve accuracy

Superconductivity in trilayer nickelate La4Ni3O10 under pressure

Nickelates gained a great deal of attention due to their similar crystal and electronic structures of cuprates over the past few decades. Recently, superconductivity with transition temperature exceeding liquid-nitrogen temperature is discovered in La3Ni2O7, which belong to the Ruddlesden-Popper (RP) phases Lan+1NinO3n+1 with n = 2. In this work, we go further and find pressure-induced superconductivity in another RP phase La4Ni3O10 (n = 3) single crystals. Our angle-resolved photoemission spectroscopy (ARPES) experiment suggest that the electronic structure of La4Ni3O10 is very similar to that of La3Ni2O7. We find that the density-wave like anomaly in resistivity is progressively suppressed with increasing pressure. A typical phase diagram is obtained with the maximum Tc of 21 Kelvin. Our study sheds light on the exploration of unconventional superconductivity in nickelates.Comment: 16 pages, 5 figure

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two

Background The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd. Methods We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background. Results First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001). Conclusions In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival

Automatic Reconstruction of High-Fidelity Blendshape Models from Images in the Wild

Facial rigs are essential to facial animation in movies, games and virtual reality applications. Among various facial models, blendshape models are widely adopted in many applications because artists can easily create complicated facial expressions through linear interpolation. However, creating high quality blendshapes for a specific subject is still a challenging task. It typically requires hours of manual work of a well-trained artists to create hundreds of blendshapes in order to achieve good visual quality. Several semi-automatic and automatic systems have been proposed to generate personalized facial rigs previously; however, such systems usually requires specialized hardware (e.g., laser scanner) or specific input (e.g., well-lit high resolution video). This thus limits the application of such systems to a wider audience. We present an automatic facial rigging system for generating person-specific 3D facial blendshapes from images in the wild (e.g., Internet images of Hillary Clinton), where the face shape, pose, expression, and illuminations are all unknown. Our system initializes the 3D blendshapes with sparse facial features detected from the input images using a mutli-linear model and then refines the blendshapes via per-pixel shading cues with a new blendshape retargeting algorithm. Finally, we introduce a new algorithm for recovering detailed facial features from the input images. To handle large variations of face poses and illuminations in the input images, we also develop a set of failure detection schemes that can robustly filter out inaccurate results in each step. Our method greatly simplifies the 3D facial rigging process and generates a more faithful face shape and expression of the subject than multi-linear model fitting. We validate the robustness and accuracy of our system using images of a dozen subjects that exhibit significant variations of face shapes, poses, expressions, and illuminations

Automatic Reconstruction of High-Fidelity Blendshape Models from Images in the Wild

Facial rigs are essential to facial animation in movies, games and virtual reality applications. Among various facial models, blendshape models are widely adopted in many applications because artists can easily create complicated facial expressions through linear interpolation. However, creating high quality blendshapes for a specific subject is still a challenging task. It typically requires hours of manual work of a well-trained artists to create hundreds of blendshapes in order to achieve good visual quality. Several semi-automatic and automatic systems have been proposed to generate personalized facial rigs previously; however, such systems usually requires specialized hardware (e.g., laser scanner) or specific input (e.g., well-lit high resolution video). This thus limits the application of such systems to a wider audience. We present an automatic facial rigging system for generating person-specific 3D facial blendshapes from images in the wild (e.g., Internet images of Hillary Clinton), where the face shape, pose, expression, and illuminations are all unknown. Our system initializes the 3D blendshapes with sparse facial features detected from the input images using a mutli-linear model and then refines the blendshapes via per-pixel shading cues with a new blendshape retargeting algorithm. Finally, we introduce a new algorithm for recovering detailed facial features from the input images. To handle large variations of face poses and illuminations in the input images, we also develop a set of failure detection schemes that can robustly filter out inaccurate results in each step. Our method greatly simplifies the 3D facial rigging process and generates a more faithful face shape and expression of the subject than multi-linear model fitting. We validate the robustness and accuracy of our system using images of a dozen subjects that exhibit significant variations of face shapes, poses, expressions, and illuminations

Scattering Points in Parallel Coordinates

In this paper, we present a novel parallel coordinates design integrated with points (Scattering Points in Parallel Coordinates, SPPC), by taking advantage of both parallel coordinates and scatterplots. Different from most multiple views visualization frameworks involving parallel coordinates where each visualization type occupies an individual window, we convert two selected neighboring coordinate axes into a scatterplot directly. Multidimensional scaling is adopted to allow converting multiple axes into a single subplot. The transition between two visual types is designed in a seamless way. In our work, a series of interaction tools has been developed. Uniform brushing functionality is implemented to allow the user to perform data selection on both points and parallel coordinate polylines without explicitly switching tools. A GPU accelerated Dimensional Incremental Multidimensional Scaling (DIMDS) has been developed to significantly improve the system performance. Our case study shows that our scheme is more efficient than traditional multi-view methods in performing visual analysis tasks