Transient Global Amnesia After Ablation of the Left Lateral Accessory Pathway

Transient global amnesia (TGA) could be encountered in many situations even during invasive procedures. In ablation therapy for arrhythmia, there was only one reported case in the ablation of premature ventricular beats. We report a 31-year-old man having paroxysmal supraventricular tachycardia who underwent TGA at the end of ablation and recovered quickly after 8-9 hours later. Long-term follow-up showed no neurologic deficits for 8 months

Patent Protection of Pharmacologically Active Metabolites: Theoretical and Technological Analysis on the Jurisprudence of Four Regions

Active metabolite patents have been instrumental for brandname pharmaceutical companies to maintain their exclusivity even after the drug patents expire. This strategy obstructs market entry of generic medicine and reduces affordable drugs. The authors review jurisprudence from the United States, Europe, India, and Taiwan in search for practical solutions to confront this problem. Given the unique pharmacological value that active metabolites may possess, patent protection for those purified or synthesized in vitro should be preserved, but for those produced by metabolism should be declined. Except India, most countries under investigation comport with this dichotomy. Their jurisprudence may be subsumed into three possible solutions. The United States and the United Kingdom adopt the inherent anticipation doctrine; yet depriving artisan recognition of novelty analysis makes this doctrine highly controversial. The product of nature doctrine gravely suffers from incoherence and uncertainty in judging patentability. The non-practice theory, as articulated by Taiwan’s Intellectual Property (IP) Court, avoids these shortcomings. The unambiguity and sound rationale further support this theory to be the preferable solution among the three

Patent Protection of Pharmacologically Active Metabolites: Theoretical and Technological Analysis on the Jurisprudence of Four Regions

Active metabolite patents have been instrumental for brandname pharmaceutical companies to maintain their exclusivity even after the drug patents expire. This strategy obstructs market entry of generic medicine and reduces affordable drugs. The authors review jurisprudence from the United States, Europe, India, and Taiwan in search for practical solutions to confront this problem. Given the unique pharmacological value that active metabolites may possess, patent protection for those purified or synthesized in vitro should be preserved, but for those produced by metabolism should be declined. Except India, most countries under investigation comport with this dichotomy. Their jurisprudence may be subsumed into three possible solutions. The United States and the United Kingdom adopt the inherent anticipation doctrine; yet depriving artisan recognition of novelty analysis makes this doctrine highly controversial. The product of nature doctrine gravely suffers from incoherence and uncertainty in judging patentability. The non-practice theory, as articulated by Taiwan’s Intellectual Property (IP) Court, avoids these shortcomings. The unambiguity and sound rationale further support this theory to be the preferable solution among the three

Nitrato[N,N,N′,N′-tetra­kis(1H-benzimid­azol-2-ylmeth­yl)ethane-1,2-diamine]­calcium(II) nitrate methanol trisolvate

In the title compound, [Ca(NO3)(C34H32N10)]NO3·3CH4O, the CaII ion is coordinated by six N atoms of the EDTB ligand {EDTB is N,N,N′,N′-tetra­kis[(2-benzimidazol­yl)meth­yl]-1,2-ethanediamine} and two O atoms from the nitrate ligand, to form a distorted dodeca­hedral geometry. The crystal packing is stabilized by inter­molecular N—H⋯O, N—H⋯N and O—H⋯O hydrogen bonds, which link the constituent units into a three-dimensional network. The uncoordinated nitrate anion is disordered over two sites, with fixed occupancies of 0.77 and 0.23

Analysis of the Rice Husk Pyrolysis Products from a Fluidized Bed Reactor

AbstractRice husks are pyrolyzed in a fluidized bed pyrolyzer using glass beads as the fluidizing media. The effects of the rice husk feeding rate and the fluidizing nitrogen gas flow rates on the mass fraction of the produced syngas, bio-oil and char are studied. The highest bio-oil mass fraction in the product is around 30% when the rice husk feeding rate and the fluidizing nitrogen gas flow rate are 10g/min and 40 L/min, respectively. The chars collected at different parts of the system are analyzed by TGA. The results indicate that although the chars have different content of volatiles, they are relatively clean. GC/MS analysing results indicate that the major compounds in the bio-oil are aromatic compounds, including toluene, phenol, furfural, methylphenol, ethylphenol, benzenediol, and etc