Intimate Partner Violence Perpetration from Adolescence to Young Adulthood: Trajectories and the Role of Familial Factors

Prior empirical research on intimate partner violence (IPV) in adolescence and young adulthood often focuses on exposure to violence in the family-of-origin using retrospective and cross-sectional data. Yet individuals’ families matter beyond simply the presence or absence of abuse, and these effects may vary across time. To address these issues, the present study employed five waves of longitudinal data from the Toledo Adolescent Relationships Study (TARS) to investigate the trajectory of IPV from adolescence to young adulthood (N = 950 respondents, 4,750 person-periods) with a specific focus on how familial factors continue to matter across the life course. Results indicated that family-of-origin violence and parent-child relationship quality were independent predictors of IPV. The effect of parent-child relationship quality on IPV also became greater as individuals aged. These results have implications for policies targeted at reducing IPV

Pre-Clinical Development of a Recombinant, Replication-Competent Adenovirus Serotype 4 Vector Vaccine Expressing HIV-1 Envelope 1086 Clade C

BackgroundThere is a well-acknowledged need for an effective AIDS vaccine that protects against HIV-1 infection or limits in vivo viral replication. The objective of these studies is to develop a replication-competent, vaccine vector based on the adenovirus serotype 4 (Ad4) virus expressing HIV-1 envelope (Env) 1086 clade C glycoprotein. Ad4 recombinant vectors expressing Env gp160 (Ad4Env160), Env gp140 (Ad4Env140), and Env gp120 (Ad4Env120) were evaluated.MethodsThe recombinant Ad4 vectors were generated with a full deletion of the E3 region of Ad4 to accommodate the env gene sequences. The vaccine candidates were assessed in vitro following infection of A549 cells for Env-specific protein expression and for posttranslational transport to the cell surface as monitored by the binding of broadly neutralizing antibodies (bNAbs). The capacity of the Ad4Env vaccines to induce humoral immunity was evaluated in rabbits for Env gp140 and V1V2-specific binding antibodies, and HIV-1 pseudovirus neutralization. Mice immunized with the Ad4Env160 vaccine were assessed for IFNγ T cell responses specific for overlapping Env peptide sets.ResultsRobust Env protein expression was confirmed by western blot analysis and recognition of cell surface Env gp160 by multiple bNAbs. Ad4Env vaccines induced humoral immune responses in rabbits that recognized Env 1086 gp140 and V1V2 polypeptide sequences derived from 1086 clade C, A244 clade AE, and gp70 V1V2 CASE A2 clade B fusion protein. The immune sera efficiently neutralized tier 1 clade C pseudovirus MW965.26 and neutralized the homologous and heterologous tier 2 pseudoviruses to a lesser extent. Env-specific T cell responses were also induced in mice following Ad4Env160 vector immunization.ConclusionsThe Ad4Env vaccine vectors express high levels of Env glycoprotein and induce both Env-specific humoral and cellular immunity thus supporting further development of this new Ad4 HIV-1 Env vaccine platform in Phase 1 clinical trials

The Long Reach of Peer Influence on Emerging Adults\u27 Sexual Activity

Researchers, parents, and adolescents recognize that peers are central to adolescent development (e.g., Waldrip, Malcolm, & Jensen-Campbell, 2008) and often influence sexual activity (e.g., Dishion, Ha, & Veronneau, 2012). Yet, despite this abundance of evidence, several questions remain. First, most research has explored the influence of peers during adolescence in predicting sexual behaviors. Much less has examined whether and to what extent peers affect emerging adults\u27 sexual behaviors both long term and contemporaneously (see Chapter 9, this volume). Second, of that research which does include an examination of peer influence on sexual activity among emerging adults, the issue of whether and how peer relationships influence sexual behaviors among individuals in committed relationships, while also accounting for characteristics of these intimate relationships, has yet to be examined. Finally, much of the literature on peer effects and sexual activity tends to be atheoretical. As such, it is difficult to determine the underlying mechanisms that account for these associations. To fill these gaps, we focused on how peers criminal activity, provision of emotional support, and permissive sexual attitudes and behaviors influenced emerging adults\u27 involvement in sexually non-exclusive behaviors, number of casual sex partners, and lifetime number of sex partners. These sexual behaviors have potential to influence the development and maintenance of committed intimate partnerships in emerging adulthood and beyond