Principal component analysis (PCA) of 5090 samples (glaucoma cases and controls) from eMERGE network.

<p>Eigenvector 1 is on x-axis and eigenvector 2 is on y-axis. Each point is a sample and they are color coded by case and control status.</p

Circular plot representing only unique gene-gene interactions.

<p>Genes are colored as red if they are expressed in eye and as grey if not expressed in the eye. All genes are ordered by chromosome. Links between the genes represent gene-gene interactions that are replicated.</p

Hierarchal plot showing 16 genes in red circles and 11 pathways in blue rectangles.

<p>Connection between the genes and pathways was established using Biofilter 2.0.</p

Flow chart explaining all the steps for gene based interaction analysis in discovery (eMERGE) and replication dataset (NEIGHBOR).

<p>Flow chart explaining all the steps for gene based interaction analysis in discovery (eMERGE) and replication dataset (NEIGHBOR).</p

POAG GWAS Results in eMERGE dataset.

<p><b>(A)</b> Manhattan plot shows chromosome and base pair positions on x-axis and -log10 of p-value on y-axis. Each point here represents a SNP. Red line is the genome-wide significance line at 5e-08. Highlighted points indicate annotation of SNPs with previously reported GWAS associated genes. <b>(B)</b> Shows a QQ-plot from GWAS analysis.</p

Heat map representing expression of the unique genes found in the ocular tissue database from GXG interaction results.

<p>Here, the x-axis lists all genes and y-axis lists the names of 10 tissues from the eye. Scale and color intensity represent PLIER values as reported in the ocular tissue database.</p

Synthesis view plot representing unique gene-gene interaction models and their p-values in discovery and replication dataset.

<p>Synthesis view plot representing unique gene-gene interaction models and their p-values in discovery and replication dataset.</p

(A) The association signal between total serum ALP and the ABO blood locus. (B): The association of lead SNPs at the ABO locus with serum ALP and their relation with ABO tag SNPs (rs8176746, rs8176704, rs505922); A significant drop in association effect in lead SNPs after controlling for ABO-tag SNPs are shown (red and black dots represent before and after conditional analyses respectively).

<p>(A) The association signal between total serum ALP and the ABO blood locus. (B): The association of lead SNPs at the ABO locus with serum ALP and their relation with ABO tag SNPs (rs8176746, rs8176704, rs505922); A significant drop in association effect in lead SNPs after controlling for ABO-tag SNPs are shown (red and black dots represent before and after conditional analyses respectively).</p

GIANT network representing interaction between <i>ROBO1</i> and <i>HTR2A</i> query genes and other genes for expression in the eye.

<p>Scale represents the confidence in the relationship shown.</p

Demographics for glaucoma samples in eMERGE discovery dataset.

<p>Demographics for glaucoma samples in eMERGE discovery dataset.</p