Rapidly Fatal Acanthamoeba Encephalitis and Treatment of Cryoglobulinemia

We describe a 66-year-old woman with therapy-refractory cryoglobulinemia treated with rituximab, plasmapheresis, and steroids; a case of fatal meningoencephalitis caused by Acanthamoeba spp. then developed. Such infections are rare and show an unusually rapid course (possibly related to rituximab)

On the vertical distribution of carbon monoxide and methane in the stratosphere

info:eu-repo/semantics/publishe

The antimicrobial resistance crisis in hospitals calls for multidisciplinary mobilization

SCOPUS: ed.jinfo:eu-repo/semantics/publishe

„Extended”-spectrum-bètalactamase- en carbapenemaseproducerende Enterobacteriaceae:therapeutische aspecten

Abstract Extended-spectrum beta-lactamaseand carbapenemase-producing Enterobacteriaceae: therapeutic options ESBL-producing (ESBL: extended-spectrum beta-lactamase) Enterobacteriaceae can be treated with a carbapenem or, to avoid the use of carbapenems and according to the indication, with fosfomycin, nitrofurantoin, tigecycline and temocillin. It is less easy to treat carbapenemase- producing Enterobacteriaceae (CPE) as the number of available drugs is limited. Only infections, but not colonisation with CPE should be treated. A prudent and restricted use of antibiotics for in- and outpatients is requested as well. An infection with a CPE has to be treated with a combination therapy: a carbapenem with colistin and/or tigecycline. A complete antibiogram with MIC-determinations (MIC: „minimal inhibitory concentration”) is very helpful. If the MIC of meropenem is ≤ 8/(16) mg/l, a highdose carbapenem can still be used. The old antibiotic colistin is also very important because there are only a few alternatives. The number of antibiotics developed during the last 20 years is limited. Most large pharmaceutical companies have reduced their antibiotic research program due to insufficient financial return. Many experts deplore this tragic evolution.status: publishe

Switch in childhood pneumococcal vaccine in Belgium

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Vaccinatie tegen pneumokokken: herziening

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Een geval van koorts, artralgieën en huiduitslag bij terugkeer uit de tropen

In this manuscript, the case of a 58-year-old woman who presented with a fever, arthralgia, a headache and a pustular skin lesion after incurring an insect bite during a stay in Sub-Saharan Africa, is discussed. A rickettsial infection was suspected and a treatment with doxycycline initiated, resulting in a spectacular improvement of the symptoms. The pustule evolved into a black eschar and serologic testing confirmed the diagnosis of a Rickettsia conorii infection. The clinical characteristics of rickettsial infections are briefly reviewed.status: publishe

Comment on: Improving access to appropriate post-exposure doxycycline for Lyme disease prophylaxis: role for community pharmacies

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Underlying factors in paediatric invasive pneumococcal disease in Belgium – Authors' reply

SCOPUS: le.jinfo:eu-repo/semantics/publishe

Pneumococcal colonization in older persons in a nonoutbreak setting

status: publishe