Concurrent Session, Integrative Knowledge and Learning: Theory, Research & Practice

How do students learn to translate knowledge gained from their coursework into real-life situations and develop the skills they will need to effectively respond to a world of constant change? This session explores how the Integrative Knowledge Portfolio Process supports students to connect, reflect on and apply the different types of knowledge, skills and capacities they’ve gained from academic and other contexts. Dr. Peet will provide an overview of a series of innovative learning methods that support integrative knowledge and present research that demonstrates the effectiveness of these methods on both educators and students. (NOTE: This is a repeat of the morning session.

A Comparative Analysis of Men’s and Women’s Sports with Respect to Types of Injury, Anatomy and Physiology, and Care and Prevention

Although studies have been performed to retrieve information about sports-related injury incidence patterns observed in high school and collegiate athletes, little research has been done to investigate the causes of the injuries that occur. This study analyzes five sports (tennis, baseball/softball, soccer, basketball, and football) to explore the connections between the sport-specific motions of each of these sports and the most common injuries that correlate in frequency with the sport. While this research answers the question of why certain athletes are prone to the injuries that correspond with their sport, it also examines care and prevention strategies with the goal of lowering the number of sports-related injuries in the United States. After reviewing numerous studies performed by injury surveillance programs, in addition to different methodologies involving care and prevention techniques, it is clear that not enough focus is being placed on training athletes properly in order to avoid injury. Therefore, this study calls for the necessary implementation of injury prevention programs into an athlete’s daily regimen that are uniquely suited for each sport being performed in order to improve strength, flexibility, and balance. Ultimately, this will simultaneously teach and reinforce the proper technique needed to perform for the highest and safest level of play

Using Multiple Methods to Assess Learning and Outcomes in an Online Degree‐Granting Dental Hygiene Program

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/153641/1/jddj002203372012764tb05273x.pd

Using Online Program Development to Foster Curricular Change and Innovation

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/153766/1/jddj002203372011753tb05047x.pd

The effect of infra-slow fluctuation neurofeedback training on a cohort of insomnia participants

Neurofeedback has gained great interest as a noninvasive treatment for various disorders. However, there is still a lack in literature regarding the effects of infra-slow fluctuation (ISF) neurofeedback training. ISF neurofeedback training is aimed at the lowest brainwave oscillations and attempts to balance dysregulated brainwave activity by inducing shifts in the parasympathetic and sympathetic response. The aim of this study was to determine whether ISF neurofeedback training has a significant effect in participants with insomnia by using quantitative electroencephalography (qEEG), Central Nervous System Vital Signs (CNS VS), and by measuring the changes of physiological vitals. The intervention consisted of 10 sessions for 40 participants separated equally into two groups. Significant results were achieved with improved core temperature (p = .002), finger temperature (p < .001), lower heart rate (p = .002), systolic (p = .003) and diastolic blood pressure (p = .001). The qEEG components significantly improved within standard ranges. An improved neurocognitive state was achieved in terms of CNS VS, with a decrease in depression (p = .003), anxiety (p < .001), and stress (p < .001). This study demonstrated that ISF neurofeedback training should be considered as a viable alternative that can be used concurrently with other insomnia treatment methods.The University of Pretoria.http://www.neuroregulation.org/am2022PhysiologyStatistic

The effect of infra-slow fluctuation neurofeedback training on a cohort of insomnia participants

This research was funded by a postgraduate masters bursary from the University of Pretoria and sponsored by Karlien Balt Neurofeedback.https://drive.google.com/file/d/1Bs2DP-PHv0JwA_tfdqjAb2x4xTbiu1um/view?usp=sharinghttps://drive.google.com/drive/folders/1fd2RsPboxRjswj5iPboFvAtbLZRpUlAQ?usp=sharinghttps://drive.google.com/drive/folders/1LW28ymQ_QNP0fDES2PvFqIeaRIdb91K2?usp=sharin

Fostering Integrative Knowledge Through ePortfolios

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/87966/1/PeetEtAl2011FosteringIntegrativeKnowledgeThroughEPortfolios.pd

“Something that helped the whole picture”: Experiences of parents offered rapid prenatal exome sequencing in routine clinical care in the English National Health Service

Objectives In October 2020, rapid prenatal exome sequencing (pES) was introduced into routine National Health Service (NHS) care in England. This study aimed to explore parent experiences and their information and support needs from the perspective of parents offered pES and of health professionals involved in its delivery. Methods in this qualitative study, semi-structured interviews were conducted with 42 women and 6 male partners and 63 fetal medicine and genetic health professionals. Interviews were transcribed verbatim and analysed using thematic analysis. Results Overall views about pES were positive and parents were grateful to be offered the test. Highlighted benefits of pES included the value of the additional information for pregnancy management and planning for future pregnancies. An anxious wait for results was common, often associated with the need to make decisions near to 24 weeks in pregnancy when there are legal restrictions for late termination. Descriptions of dealing with uncertainty were also common, even once results had been returned. Many parents described pES results informing decision-making around whether or not to terminate pregnancy. Some professionals were concerned that a non-informative result could be overly reassuring and highlighted that careful counselling was needed to ensure parents have a good understanding of what the result means for their pregnancy. Emotional support from professionals was valued, however some parents felt that post-test support was lacking. Conclusion Parents and professionals welcomed the introduction of pES. Results inform parents’ decision making around termination of pregnancy. When there are no diagnostic findings or uncertain findings from pES, personalised counselling that considers scans and other tests is crucial. Directing parents to reliable online sources of information and providing emotional support throughout could improve their experiences of care

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis

Malaria and cryptosporidiosis, caused by apicomplexan parasites, remain major drivers of global child mortality. New drugs for the treatment of malaria and cryptosporidiosis, in particular, are of high priority; however, there are few chemically validated targets. The natural product cladosporin is active against blood- and liver-stage; Plasmodium falciparum; and; Cryptosporidium parvum; in cell-culture studies. Target deconvolution in; P. falciparum; has shown that cladosporin inhibits lysyl-tRNA synthetase (; Pf; KRS1). Here, we report the identification of a series of selective inhibitors of apicomplexan KRSs. Following a biochemical screen, a small-molecule hit was identified and then optimized by using a structure-based approach, supported by structures of both; Pf; KRS1 and; C. parvum; KRS (; Cp; KRS). In vivo proof of concept was established in an SCID mouse model of malaria, after oral administration (ED; 90; = 1.5 mg/kg, once a day for 4 d). Furthermore, we successfully identified an opportunity for pathogen hopping based on the structural homology between; Pf; KRS1 and; Cp; KRS. This series of compounds inhibit; Cp; KRS and; C. parvum; and; Cryptosporidium hominis; in culture, and our lead compound shows oral efficacy in two cryptosporidiosis mouse models. X-ray crystallography and molecular dynamics simulations have provided a model to rationalize the selectivity of our compounds for; Pf; KRS1 and; Cp; KRS vs. (human); Hs; KRS. Our work validates apicomplexan KRSs as promising targets for the development of drugs for malaria and cryptosporidiosis