Development of <i>C</i>₂‑Symmetric Chiral Bifunctional Triamines: Synthesis and Application in Asymmetric Organocatalysis

The synthesis and application of a newly designed <i>C</i>₂-symmetric chiral bifunctional triamine family (<i>C</i>₂-CBT) is reported. These enantiopure chiral triamine scaffolds can be accessed in multigram amounts from simple amino acids while avoiding chromatographic purification. As a proof of principle, <i>C</i>₂-CBT has been studied in the aldol reaction of cyclic ketones with isatins, with the target tertiary alcohols being formed in a highly efficient manner. Catalyst recovery by simple extraction techniques and subsequent reuse has been performed

Number of PAU exams and exercises analysed.

<p>Number of PAU exams and exercises analysed.</p

Washback Effect of University Entrance exams in Applied Mathematics to Social Sciences

<div><p>Curricular issues of subject Applied Mathematics to Social Sciences are studied in relation to university entrance exams performed in several Spanish regions between 2009–2014. By using quantitative and qualitative analyses, it has been studied how these exams align with curriculum and how they produce a washback on curriculum and teachers’ work. Additionally, one questionnaire about teachers’ practices has been performed, in order to find out how the exams are influencing teaching methodology development. Main results obtained show that evaluation is producing a bias on the official curriculum, substantially simplifying the specific orientation that should guide applied mathematics. Furthermore, teachers’ practices are influenced by the exams, and they usually approach their teaching methodology to the frequent types of exams. Also, slight differences among the teachers lead to distinguish two behavioral subgroups. Results can also be useful in an international context, because of the importance of standardized exit exams in OECD countries.</p></div

CU’s from Calculus block.

<p>CU’s from Calculus block.</p

Scalable Synthesis of the Amber Odorant 9-<i>epi</i>-Ambrox through a Biomimetic Cationic Cyclization/Nucleophilic Bromination Reaction

A novel biomimetic nucleophilic bromocyclization reaction is used in the key step of a new and straightforward synthesis of 9-<i>epi</i>-Ambrox, an organic compound of high interest and value in the context of fragrances. This strategic reaction allows access to 9-<i>epi</i>-Ambrox on a gram scale from a dienyne derivative, easily available from geraniol, following a sequence of seven steps (35% global yield) with just one purification process. Both enantiomers of the molecule were obtained by a challenging enzymatic resolution

Algebra: Appearance percentage of CU’s.

<p>Algebra: Appearance percentage of CU’s.</p

Calculus: Appearance percentage of CU’s

<p>Calculus: Appearance percentage of CU’s</p

CU’s from Probability & Statistics block.

<p>CU’s from Probability & Statistics block.</p

Cluster analysis.

<p>Clusters plotted over the two main dimensions in scores (biggest points represent group average)</p

Obtained p-values from tests on answers to open questions (Fisher test in the first column and Barnard test in the rest).

<p>Obtained p-values from tests on answers to open questions (Fisher test in the first column and Barnard test in the rest).</p