VLT identification of the optical afterglow of the gamma-ray burst GRB 000131 at z=4.50

We report the discovery of the gamma-ray burst GRB 000131 and its optical afterglow. The optical identification was made with the VLT 84 hours after the burst following a BATSE detection and an Inter Planetary Network localization. GRB 000131 was a bright, long-duration GRB, with an apparent precursor signal 62 s prior to trigger. The afterglow was detected in ESO VLT, NTT, and DK1.54m follow-up observations. Broad-band and spectroscopic observations of the spectral energy distribution reveals a sharp break at optical wavelengths which is interpreted as a Ly-alpha absorption edge at 6700 A. This places GRB 000131 at a redshift of 4.500 +/- 0.015. The inferred isotropic energy release in gamma rays alone was approximately 10^54 erg (depending on the assumed cosmology). The rapid power-law decay of the afterglow (index alpha=2.25, similar to bursts with a prior break in the lightcurve), however, indicates collimated outflow, which relaxes the energy requirements by a factor of < 200. The afterglow of GRB 000131 is the first to be identified with an 8-m class telescope.Comment: 8 pages, 7 figures, accepted to A&A Letter

GRB 000301C: a possible short/intermediate duration burst connected to a DLA system

We discuss two main aspects of the GRB 000301C afterglow (Fynbo et al. 2000, Jensen et al. 2000); its short duration and its possible connection with a Damped Ly-alpha Absorber (DLA). GRB 000301C falls in the short class of bursts, though it is consistent with belonging to the proposed intermediate class or the extreme short end of the distribution of long-duration GRBs. Based on two VLT spectra we estimate the HI column density to be Log(N(HI))=21.2+/-0.5. This is the first direct indication of a connection between GRB host galaxies and Damped Ly-alpha Absorbers.Comment: 3 pages, 3 postscript figures. To appear in the proceedings of the October 2000 Rome Workshop on ``Gamma-Ray Bursts in the Afterglow Era'

The bright Gamma-Ray Burst of February 10, 2000: a case study of an optically dark GRB

The gamma-ray burst GRB000210 had the highest gamma-ray peak flux of any event localized by BeppoSAX as yet but it did not have a detected optical afterglow. It is therefore one of the events recently classified as dark GRBs or GHOST (GRB Hiding Optical Source Transient), whose origin is still unclear. Chandra observations allowed us to localize this GRB within ~1" and a radio transient was detected with the VLA. We identify the likely (P=0.01) host galaxy of this burst at z=0.846. The X-ray spectrum of the afterglow shows intrinsic absorption N_H=5x10**21 cm-2. The amount of dust needed to absorb the optical flux of this object is consistent with the above HI column density, given a dust-to-gas ratio similar to that of our Galaxy. We do not find evidence for a partially ionized absorber expected if the absorption takes place in a Giant Molecular Cloud. We therefore conclude that either the gas is local to the GRB, but is condensed in small-scale high-density (n>~10**9 cm-3) clouds, or that the GRB is located in a dusty, gas-rich region of the galaxy. Finally, if GRB000210 lies at z>5, its X-ray absorbing medium would have to be substantially different from that observed in GRBs with optical afterglows.Comment: 29 pages, 7 fig.s, some revisions, ApJ, in pres

Multi-Wavelength Studies of the Optically Dark Gamma-Ray Burst 001025A

We identify the fading X-ray afterglow of GRB 001025A from XMM-Newton observations obtained 1.9-2.3 days, 2 years, and 2.5 years after the burst. The non-detection of an optical counterpart to an upper limit of R=25.5, 1.20 days after the burst, makes GRB 001025A a ``dark'' burst. Based on the X-ray afterglow spectral properties of GRB 001025A, we argue that some bursts appear optically dark because their afterglow is faint and their cooling frequency is close to the X-ray band. This interpretation is applicable to several of the few other dark bursts where the X-ray spectral index has been measured. The X-ray afterglow flux of GRB 001025A is an order of magnitude lower than for typical long-duration gamma-ray bursts. The spectrum of the X-ray afterglow can be fitted with an absorbed synchrotron emission model, an absorbed thermal plasma model, or a combination thereof. For the latter, an extrapolation to optical wavelengths can be reconciled with the R-band upper limit on the afterglow, without invoking any optical circumburst absorption, provided the cooling frequency is close to the X-ray band. Alternatively, if the X-ray afterglow is due to synchrotron emission only, seven magnitudes of extinction in the observed R-band is required to meet the R-band upper limit, making GRB 001025A much more obscured than bursts with detected optical afterglows. Based on the column density of X-ray absorbing circumburst matter, an SMC gas-to-dust ratio is insufficient to produce this amount of extinction. The X-ray tail of the prompt emission enters a steep temporal decay excluding that the tail of the prompt emission is the onset of the afterglow (abridged).Comment: 32 pages, 8 figures, ApJ in pres

Insulin and GH Signaling in Human Skeletal Muscle In Vivo following Exogenous GH Exposure: Impact of an Oral Glucose Load

GH induces acute insulin resistance in skeletal muscle in vivo, which in rodent models has been attributed to crosstalk between GH and insulin signaling pathways. Our objective was to characterize time course changes in signaling pathways for GH and insulin in human skeletal muscle in vivo following GH exposure in the presence and absence of an oral glucose load.Eight young men were studied in a single-blinded randomized crossover design on 3 occasions: 1) after an intravenous GH bolus 2) after an intravenous GH bolus plus an oral glucose load (OGTT), and 3) after intravenous saline plus OGTT. Muscle biopsies were taken at t = 0, 30, 60, and 120. Blood was sampled at frequent intervals for assessment of GH, insulin, glucose, and free fatty acids (FFA).GH increased AUC(glucose) after an OGTT (p<0.05) without significant changes in serum insulin levels. GH induced phosphorylation of STAT5 independently of the OGTT. Conversely, the OGTT induced acute phosphorylation of the insulin signaling proteins Akt (ser(473) and thr(308)), and AS160.The combination of OGTT and GH suppressed Akt activation, whereas the downstream expression of AS160 was amplified by GH. WE CONCLUDED THE FOLLOWING: 1) A physiological GH bolus activates STAT5 signaling pathways in skeletal muscle irrespective of ambient glucose and insulin levels 2) Insulin resistance induced by GH occurs without a distinct suppression of insulin signaling proteins 3) The accentuation of the glucose-stimulated activation of AS 160 by GH does however indicate a potential crosstalk between insulin and GH.ClinicalTrials.gov NCT00477997

Impact of Non-HIV and HIV Risk Factors on Survival in HIV-Infected Patients on HAART: A Population-Based Nationwide Cohort Study

BACKGROUND: We determined the impact of three factors on mortality in HIV-infected patients who had been on highly active antiretroviral therapy (HAART) for at least one year: (1) insufficient response to (HAART) and presence of AIDS-defining diseases, (2) comorbidity, and (3) drug and alcohol abuse and compared the mortality to that of the general population. METHODOLOGY/PRINCIPAL FINDINGS: In a Danish nationwide, population-based cohort study, we used population based registries to identify (1) all Danish HIV-infected patients who started HAART in the period 1 January 1998-1 July 2009, and (2) a comparison cohort of individuals matched on date of birth and gender (N = 2,267 and 9,068, respectively). Study inclusion began 1 year after start of HAART. Patients were categorised hierarchically in four groups according to the three risk factors, which were identified before study inclusion. The main outcome measure was probability of survival from age 25 to 65 years. The probability of survival from age 25 to age 65 was substantially lower in HIV patients [0.48 (95% confidence interval (CI) 0.42-0.55)] compared to the comparison cohort [0.88 (0.86 to 0.90)]. However, in HIV patients with no risk factors (N = 871) the probability of survival was equivalent to that of the general population [0.86 (95% CI 0.77-0.92)]. In contrast, the probability of survival was 0.58 in patients with HIV risk factors (N = 704), 0.30 in patients with comorbidities (N = 479), and 0.03 in patients with drug or alcohol abuse (N = 313). CONCLUSIONS: The increased risk of death in HIV-infected individuals is mainly attributable to risk factors that can be identified prior to or in the initial period of antiretroviral treatment. Mortality in patients without risk factors on a successful HAART is almost identical to that of the non-HIV-infected population