Comparison of Kinesio Taping and Traditional Non-elastic Prophylactic Ankle Taping on Ankle Range of Motion and Musculotendinous Stiffness in Division I Tennis Athletes

Context: Kinesio tape (KT) is an elastic tape that can be utilized in any phase of injury as an intervention for increasing lymphatic drainage, facilitating or inhibiting muscle activity, providing ligament and tendon support and functional correction. While the KT brand claims to provide patients a variety of therapeutic benefits, there is limited research to support these claims. Objective: The purpose of this study was to compare the effect of KT for functional correction by assisting dorsiflexion (DF) and eversion (EV) and inhibiting plantar flexion (PF) and inversion (IV). Design: Randomized crossover study design. Setting: Clinical setting. Patients/Participants: 19 Division I Tennis Athletes, 10 males and 9 females. Interventions: Participants were randomly assigned to start with no tape (NT), KT or traditional, non-elastic tape (WT) and randomly assigned to start with PF/DF or IV/EV for a one-time test on the Biodex 3 isokinetic dynamometer. Main Outcome Measure(s): Each participant�s range of motion (ROM) and musculotendinous were measured using a Biodex 3 isokinestic dynamometer. Musculotendinous stiffness was calculated as the slope of the angle-torque curve generated by the Biodex 3. Results: No significant difference was found between NT and KT for ROM and MTS in any direction of ankle motion. A significant decrease in ROM was found between NT and WT for PF and EV, as well as MTS of the dorsiflexion muscle group. Significant differences were found between WT and KT for PF ROM and the DF muscle group. Conclusion: Results of this study do not support the claims of KT for functional correction to assist dorsiflexion and eversion and inhibit plantar flexion and inversion. These results do not justify the use of KT as an alternative to traditional, non-elastic prophylactic tape for preventing ankle injuries. Key words: Kinesio tape, musculotendinous stiffness, range of motion, ankle tape, taping, ankle sprains.Health & Human Performance (MS

1972: Abilene Christian College Bible Lectures - Full Text

THE CHURCH AND THE FUTURE Being the Abilene Christian College Annual Bible Lectures 1972 Published by ABILENE CHRISTIAN COLLEGE BOOK STORE ACC Station Abilene, Texas 7960

The Euro-American Impact on Navajo Aesthetics

Traditional Navajo weaving was sparked by the practicality of blankets and textiles in Navajo settlements, but trade and migration pioneered the shifts in what was commonly considered aesthetically pleasing and popular within the artform leading to the quintessential designs of Navajo weavings today. With this research, I have decided to pursue a hands-on research approach – a physical research project created by hand with a written account of the research both supporting my claim of trade impact on the evolution of weaving. I can justify the necessity of the personal project by creating two small weavings using an older technique for the first and a newer, evolved technique for the second. The use of the two smaller weavings will demonstrate change and growth ofthe aesthetics in Navajo weavings and the impact of trade amongst the Great Basin and European Americans

An Exploration of Therapeutic Applications for Dinitrosyl Iron Complexes (DNIC's)

The therapeutic nature and mechanisms of in vitro nitric oxide (NO) release from dinitrosyl iron complexes (DNICs) are explored herein. First, the ideal primary coordination environment for the sustained liberation of NO while limiting the toxicity related to iron and NO was investigated. Dimeric RRE-type {Fe(NO)2}9 complexes, SPhRRE [(µ-SPh)Fe(NO)2]2 and TGTA-RRE, [(µ-S-TGTA)Fe(NO)2]2 (TGTA = 1-thio-β-d-glucose tetraacetate), were found to deliver NO with the lowest effect on cell toxicity (i.e., highest IC50) with TGTA-RRE delivering a higher concentration of NO to the cytosol of SMCs. Monomeric DNICs with bulky N-heterocyclic carbenes (NHC), namely 1,3-bis(2,4,6-trimethylphenyl)imidazolidene (IMes), have IC50’s of ~7 µM, but didn’t release NO into SMCs. The reduced, mononuclear {Fe(NO)2}10 neocuproine-based DNIC increased intracellular NO. Given the efficacy of TGTA-RRE, instead of redesigning entirely new DNICs, the release rate of NO was tuned with the addition of biomolecules histidine and glutathione. From the Griess assay and X-band EPR data, decomposition of the histidine-cleaved dimer, [(TGTA)(NHis)Fe(NO)2], generated Fe(III) and increased the NO release rate compared to the TGTA-RRE precursor. In contrast, increasing concentrations of glutathione generated the stable [(TGTA)(GS)Fe(NO)2]- and depressed the NO release rate. This work provides insight into tuning NO release beyond the design of DNICs, through the incubation with biomolecules. A structure activity relationship between thiolate identity and expected protease inhibition was investigated in silico and in vitro via AutoDock 4.2.6 (AD4) and FRET protease assays respectively. AD4 was validated for coordinatively unsaturated DNIC binding using a crystal structure of a protein-bound DNIC, PDB – 1ZGN (calculation RMSD = 1.77). The dimeric DNICs TGTA-RRE and TG-RRE, [(µ-S-TG)Fe(NO)2]2 (TG = 1-thio-β-d-glucose), were identified as leads via the in silico study. Computations suggest inhibition at the catalytic Cys145 of SC2Mpro. In vitro studies indicate inhibition of protease activity upon TGTA-RRE treatment, with an IC50 of 38 µM for TGTA-RRE and 33 µM for TG-RRE. This study presents a simple computational method for predicting DNIC-protein interactions as well as validating the in silico leads in vitro