6,776 research outputs found
Opportunities in cancer imaging: a review of oesophageal, gastric and colorectal malignancies
The incidence of gastrointestinal (GI) malignancy is increasing worldwide. In particular, there is a concerning rise in incidence of GI cancer in younger adults. Direct endoscopic visualisation of luminal tumour sites requires invasive procedures, which are associated with certain risks, but remain necessary because of limitations in current imaging techniques and the continuing need to obtain tissue for diagnosis and genetic analysis; however, management of GI cancer is increasingly reliant on non-invasive, radiological imaging to diagnose, stage, and treat these malignancies. Oesophageal, gastric, and colorectal malignancies require specialist investigation and treatment due to the complex nature of the anatomy, biology, and subsequent treatment strategies. As cancer imaging techniques develop, many opportunities to improve tumour detection, diagnostic accuracy and treatment monitoring present themselves. This review article aims to report current imaging practice, advances in various radiological modalities in relation to GI luminal tumour sites and describes opportunities for GI radiologists to improve patient outcomes
Microbiology testing associated with antibiotic dispensing in older community-dwelling adults.
BACKGROUND:It is commonly recommended that microbiological assessment should accompany the use of antibiotics prone to resistance. We sought to estimate the rate of microbiology testing and compare this to dispensing of the World Health Organization classified "watch" group antibiotics in primary care. METHODS:Data from a cohort of older adults (mean age 69 years) were linked to Australian national health insurance (Pharmaceutical Benefits Scheme & Medicare Benefits Schedule) records of community-based antibiotic dispensing and microbiology testing in 2015. Participant characteristics associated with greater watch group antibiotic dispensing and microbiology testing were estimated using adjusted incidence rate ratios (aIRR) and 95% confidence intervals (CI) in multivariable zero-inflated negative binomial regression models. RESULTS:In 2015, among 244,299 participants, there were 63,306 watch group antibiotic prescriptions dispensed and 149,182 microbiology tests conducted; the incidence rate was 0.26 per person-year for watch group antibiotic dispensing and 0.62 for microbiology testing. Of those antibiotic prescriptions, only 19% were accompanied by microbiology testing within - 14 to + 7 days. After adjusting for socio-demographic factors and co-morbidities, individuals with chronic respiratory diseases were more likely to receive watch group antibiotics than those without, e.g. asthma (aIRR:1.59, 95%CI:1.52-1.66) and chronic obstructive pulmonary disease (COPD) (aIRR:2.71, 95%CI:2.48-2.95). However, the rate of microbiology testing was not comparably higher among them (with asthma aIRR:1.03, 95%CI:1.00-1.05; with COPD aIRR:1.00, 95%CI:0.94-1.06). CONCLUSIONS:Priority antibiotics with high resistance risk are commonly dispensed among community-dwelling older adults. The discord between the rate of microbiology testing and antibiotic dispensing in adults with chronic respiratory diseases suggests the potential for excessive empirical prescribing
Hyperfine Fields in an Ag/Fe Multilayer Film Investigated with 8Li beta-Detected Nuclear Magnetic Resonance
Low energy -detected nuclear magnetic resonance (-NMR) was used
to investigate the spatial dependence of the hyperfine magnetic fields induced
by Fe in the nonmagnetic Ag of an Au(40 \AA)/Ag(200 \AA)/Fe(140 \AA) (001)
magnetic multilayer (MML) grown on GaAs. The resonance lineshape in the Ag
layer shows dramatic broadening compared to intrinsic Ag. This broadening is
attributed to large induced magnetic fields in this layer by the magnetic Fe
layer. We find that the induced hyperfine field in the Ag follows a power law
decay away from the Ag/Fe interface with power , and a field
extrapolated to T at the interface.Comment: 5 pages, 4 figure. To be published in Phys. Rev.
Computerized Adaptive Assessment of Infant-Toddler Language Development: Demonstration and Validation of an App for Screening
We have developed a computerized adaptive test (an app), based on the MacArthur-Bates Communicative Development Inventories (CDI), that can rapidly gauge infant and toddler language development based on parent report. The app can be very useful in screening for developmental disabilities in IDEA Part C or Section 619. We will demonstrate the app and present validation data for toddlers.https://digitalcommons.library.umaine.edu/ccids_posters/1005/thumbnail.jp
Modeling of Covalent Bonding in Solids by Inversion of Cohesive Energy Curves
We provide a systematic test of empirical theories of covalent bonding in
solids using an exact procedure to invert ab initio cohesive energy curves. By
considering multiple structures of the same material, it is possible for the
first time to test competing angular functions, expose inconsistencies in the
basic assumption of a cluster expansion, and extract general features of
covalent bonding. We test our methods on silicon, and provide the direct
evidence that the Tersoff-type bond order formalism correctly describes
coordination dependence. For bond-bending forces, we obtain skewed angular
functions that favor small angles, unlike existing models. As a
proof-of-principle demonstration, we derive a Si interatomic potential which
exhibits comparable accuracy to existing models.Comment: 4 pages revtex (twocolumn, psfig), 3 figures. Title and some wording
(but no content) changed since original submission on 24 April 199
Equation of state of asymmetric nuclear matter and collisions of neutron-rich nuclei
The ratio of pre-equilibrium neutrons to protons from collisions of
neutron-rich nuclei is studied as a function of their kinetic energies. This
ratio is found to be sensitive to the density dependence of the nuclear
symmetry energy, but is independent of the compressibility of symmetric nuclear
matter and the in-medium nucleon-nucleon cross sections. The experimental
measurement of this ratio thus provides a novel means for determining the
nuclear equation of state of asymmetric nuclear matter.Comment: 11 pages + 3 postscript figures, Phys. Rev. Lett. (1997) in pres
Micro-computed tomographic analysis of the radial geometry of intrarenal artery-vein pairs in rats and rabbits: Comparison with light microscopy
We assessed the utility of synchrotron-radiation micro-computed tomography (micro-CT) for quantification of the radial geometry of the renal cortical vasculature. The kidneys of nine rats and six rabbits were perfusion fixed and the renal circulation filled with Microfil. In order to assess shrinkage of Microfil, rat kidneys were imaged at the Australian Synchrotron immediately upon tissue preparation and then post fixed in paraformaldehyde and reimaged 24 hours later. The Microfil shrank only 2-5% over the 24 hour period. All subsequent micro-CT imaging was completed within 24 hours of sample preparation. After micro-CT imaging, the kidneys were processed for histological analysis. In both rat and rabbit kidneys, vascular structures identified in histological sections could be identified in two-dimensional (2D) micro-CT images from the original kidney. Vascular morphology was similar in the two sets of images. Radial geometry quantified by manual analysis of 2D images from micro-CT was consistent with corresponding data generated by light microscopy. However, due to limited spatial resolution when imaging a whole organ using contrast-enhanced micro-CT, only arteries ≥100 and ≥60 μm in diameter, for the rat and rabbit respectively, could be assessed. We conclude that it is feasible and valid to use micro-CT to quantify vascular geometry of the renal cortical circulation in both the rat and rabbit. However, a combination of light microscopic and micro-CT approaches are required to evaluate the spatial relationships between intrarenal arteries and veins over an extensive range of vessel size
Neutron-Proton Differential Flow as a Probe of Isospin-Dependence of Nuclear Equation of State
The neutron-proton differential flow is shown to be a very useful probe of
the isospin-dependence of the nuclear equation of state (EOS). This novel
approach utilizes constructively both the isospin fractionation and the nuclear
collective flow as well as their sensitivities to the isospin-dependence of the
nuclear EOS. It also avoids effectively uncertainties associated with other
dynamical ingredients of heavy-ion reactions at intermediate energies.Comment: 10 pages + 3 figures. Phys. Rev. Lett. (2000) in pres
Beyond scaling and locality in turbulence
An analytic perturbation theory is suggested in order to find finite-size
corrections to the scaling power laws. In the frame of this theory it is shown
that the first order finite-size correction to the scaling power laws has
following form , where
is a finite-size scale (in particular for turbulence, it can be the Kolmogorov
dissipation scale). Using data of laboratory experiments and numerical
simulations it is shown shown that a degenerate case with can
describe turbulence statistics in the near-dissipation range , where
the ordinary (power-law) scaling does not apply. For moderate Reynolds numbers
the degenerate scaling range covers almost the entire range of scales of
velocity structure functions (the log-corrections apply to finite Reynolds
number). Interplay between local and non-local regimes has been considered as a
possible hydrodynamic mechanism providing the basis for the degenerate scaling
of structure functions and extended self-similarity. These results have been
also expanded on passive scalar mixing in turbulence. Overlapping phenomenon
between local and non-local regimes and a relation between position of maximum
of the generalized energy input rate and the actual crossover scale between
these regimes are briefly discussed.Comment: extended versio
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