4,617 research outputs found

    Don\u27t Repeat a Word of This!

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    Can you write a composition of 100 words or more without repeating a single word? Without using even an a or an an or a the more than once

    Informal dramatic materials for the development of speech sounds in the primary grades

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    Thesis (Ed.M.)--Boston Universit

    Beyond the CMSSM without an Accelerator: Proton Decay and Direct Dark Matter Detection

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    We consider two potential non-accelerator signatures of generalizations of the well-studied constrained minimal supersymmetric standard model (CMSSM). In one generalization, the universality constraints on soft supersymmetry-breaking parameters are applied at some input scale MinM_{in} below the grand unification (GUT) scale MGUTM_{GUT}, a scenario referred to as `sub-GUT'. The other generalization we consider is to retain GUT-scale universality for the squark and slepton masses, but to relax universality for the soft supersymmetry-breaking contributions to the masses of the Higgs doublets. As with other CMSSM-like models, the measured Higgs mass requires supersymmetric particle masses near or beyond the TeV scale. Because of these rather heavy sparticle masses, the embedding of these CMSSM-like models in a minimal SU(5) model of grand unification can yield a proton lifetime consistent with current experimental limits, and may be accessible in existing and future proton decay experiments. Another possible signature of these CMSSM-like models is direct detection of supersymmetric dark matter. The direct dark matter scattering rate is typically below the reach of the LUX-ZEPLIN (LZ) experiment if MinM_{in} is close to MGUTM_{GUT}, but may lie within its reach if Min1011M_{in} \lesssim 10^{11} GeV. Likewise, generalizing the CMSSM to allow non-universal supersymmetry-breaking contributions to the Higgs offers extensive possibilities for models within reach of the LZ experiment that have long proton lifetimes.Comment: 42 pages, 15 figure

    Superconducting film with randomly magnetized dots: A realization of the 2D XY model with random phase shifts

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    We consider a thin superconducting film with randomly magnetized dots on top of it. The dots produce a disordered pinning potential for vortices in the film. We show that for dots with permanent and random magnetization normal or parallel to the film surface, our system is an experimental realization of the two-dimensional XY model with random phase shifts. The low-temperature superconducting phase, that exists without magnetic dots, survives in the presence of magnetic dots for sufficiently small disorder.Comment: 5 pages, 1 figur

    Crystal structure of the catalytic fragment of murine poly(ADP-ribose) polymerase-2.

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    Poly(ADP-ribose) polymerase-1 (PARP-1) has become an important pharmacological target in the treatment of cancer due to its cellular role as a 'DNA-strand break sensor', which leads in part to resistance to some existing chemo- and radiological treatments. Inhibitors have now been developed which prevent PARP-1 from synthesizing poly(ADP-ribose) in response to DNA-breaks and potentiate the cytotoxicity of DNA damaging agents. However, with the recent discoveries of PARP-2, which has a similar DNA-damage dependent catalytic activity, and additional members containing the 'PARP catalytic' signature, the isoform selectivity and resultant pharmacological effects of existing inhibitors are brought into question. We present here the crystal structure of the catalytic fragment of murine PARP-2, at 2.8 A resolution, and compare this to the catalytic fragment of PARP-1, with an emphasis on providing a possible framework for rational drug design in order to develop future isoform-specific inhibitors

    Structural change of vortex patterns in anisotropic Bose-Einstein condensates

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    We study the changes in the spatial distribution of vortices in a rotating Bose-Einstein condensate due to an increasing anisotropy of the trapping potential. Once the rotational symmetry is broken, we find that the vortex system undergoes a rich variety of structural changes, including the formation of zig-zag and linear configurations. These spatial re-arrangements are well signaled by the change in the behavior of the vortex-pattern eigenmodes against the anisotropy parameter. The existence of such structural changes opens up possibilities for the coherent exploitation of effective many-body systems based on vortex patterns.Comment: 5 pages, 4 figure
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