8 research outputs found
Tri- and difluoromethoxylated N-based heterocycles â Synthesis and insecticidal activity of novel F3CO- and F2HCO-analogues of Imidacloprid and Thiacloprid
International audienc
Recent advances in transition metal-catalyzed Csp(2)-monofluoro-, difluoro-, perfluoromethylation and trifluoromethylthiolation
In the last few years, transition metal-mediated reactions have joined the toolbox of chemists working in the field of fluorination for Life-Science oriented research. The successful execution of transition metal-catalyzed carbonâfluorine bond formation has become a landmark achievement in fluorine chemistry. This rapidly growing research field has been the subject of some excellent reviews. Our approach focuses exclusively on transition metal-catalyzed reactions that allow the introduction of âCFH2, âCF2H, âCnF2n+1 and âSCF3 groups onto spÂČ carbon atoms. Transformations are discussed according to the reaction-type and the metal employed. The review will not extend to conventional non-transition metal methods to these fluorinated groups
A General Approach towards NH-Pyrazoles That Bear Diverse Fluoroalkyl Groups by Means of Fluorinated Iminium Salts
Fluoroalkyl Amino Reagents (FARs): A General Approach towards the Synthesis of Heterocyclic Compounds Bearing Emergent Fluorinated Substituents
Fluorinated heterocycles are important building blocks in pharmaceutical, agrochemical and material sciences. Therefore, organofluorine chemistry has witnessed high interest in the development of efficient methods for the introduction of emergent fluorinated substituents (EFS) onto heterocycles. In this context, fluoroalkyl amino reagents (FARs)âa class of chemicals that was slightly forgotten over the last decadesâhas emerged again recently and proved to be a powerful tool for the introduction of various fluorinated groups onto (hetero)aromatic derivatives
A New Synthesis and Process Development of Bis(fluoroalkyl)pyrazoles As Novel Agrophores
The synthesis of 3,5-bisÂ(fluoroalkyl)-pyrazoles
as novel agrophores
is described. Commercially available fluoroacetoacetates are treated
with BF<sub>3</sub>-activated TFEDMA affording in a straightforward
one-pot sequence pyrazole carboxylates in good yields and with excellent
regioselectivity. The carboxylate intermediates have been converted
into the corresponding pyrazolic acids and submitted to decarboxylation,
affording valuable building blocks for the design of novel bioactive
ingredients. The found process is suitable for scale up and preparation
of compounds in kilogram quantity
Trifluoromethyl ethers â synthesis and properties of an unusual substituent
After nitrogen, fluorine is probably the next most favorite hetero-atom for incorporation into small molecules in life science-oriented research. This review focuses on a particular fluorinated substituent, the trifluoromethoxy group, which is finding increased utility as a substituent in bioactives, but it is still perhaps the least well understood fluorine substituent in currency. The present review will give an overview of the synthesis, properties and reactivity of this important substituent