71 research outputs found

    Communities and Local Energy: A Workbook--The Future Is Now

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    Prepared in partnership with the Minnesota Project by the Community Assistantship Program (CAP) administered by the Center for Urban and Regional Affairs, University of Minnesota

    Rapid Effects of Hearing Song on Catecholaminergic Activity in the Songbird Auditory Pathway

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    Catecholaminergic (CA) neurons innervate sensory areas and affect the processing of sensory signals. For example, in birds, CA fibers innervate the auditory pathway at each level, including the midbrain, thalamus, and forebrain. We have shown previously that in female European starlings, CA activity in the auditory forebrain can be enhanced by exposure to attractive male song for one week. It is not known, however, whether hearing song can initiate that activity more rapidly. Here, we exposed estrogen-primed, female white-throated sparrows to conspecific male song and looked for evidence of rapid synthesis of catecholamines in auditory areas. In one hemisphere of the brain, we used immunohistochemistry to detect the phosphorylation of tyrosine hydroxylase (TH), a rate-limiting enzyme in the CA synthetic pathway. We found that immunoreactivity for TH phosphorylated at serine 40 increased dramatically in the auditory forebrain, but not the auditory thalamus and midbrain, after 15 min of song exposure. In the other hemisphere, we used high pressure liquid chromatography to measure catecholamines and their metabolites. We found that two dopamine metabolites, dihydroxyphenylacetic acid and homovanillic acid, increased in the auditory forebrain but not the auditory midbrain after 30 min of exposure to conspecific song. Our results are consistent with the hypothesis that exposure to a behaviorally relevant auditory stimulus rapidly induces CA activity, which may play a role in auditory responses

    Noradrenergic Control of Gene Expression and Long-Term Neuronal Adaptation Evoked by Learned Vocalizations in Songbirds

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    Norepinephrine (NE) is thought to play important roles in the consolidation and retrieval of long-term memories, but its role in the processing and memorization of complex acoustic signals used for vocal communication has yet to be determined. We have used a combination of gene expression analysis, electrophysiological recordings and pharmacological manipulations in zebra finches to examine the role of noradrenergic transmission in the brain’s response to birdsong, a learned vocal behavior that shares important features with human speech. We show that noradrenergic transmission is required for both the expression of activity-dependent genes and the long-term maintenance of stimulus-specific electrophysiological adaptation that are induced in central auditory neurons by stimulation with birdsong. Specifically, we show that the caudomedial nidopallium (NCM), an area directly involved in the auditory processing and memorization of birdsong, receives strong noradrenergic innervation. Song-responsive neurons in this area express Ξ±-adrenergic receptors and are in close proximity to noradrenergic terminals. We further show that local Ξ±-adrenergic antagonism interferes with song-induced gene expression, without affecting spontaneous or evoked electrophysiological activity, thus dissociating the molecular and electrophysiological responses to song. Moreover, Ξ±-adrenergic antagonism disrupts the maintenance but not the acquisition of the adapted physiological state. We suggest that the noradrenergic system regulates long-term changes in song-responsive neurons by modulating the gene expression response that is associated with the electrophysiological activation triggered by song. We also suggest that this mechanism may be an important contributor to long-term auditory memories of learned vocalizations

    A study on economic diversity and economic stability

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    Includes bibliographical references (pages 48-50)The hypothesis that economic diversity promotes economic stability has always been attractive to planners and economic development officials. However, research has failed to prove that a clear relationship exists. This research tests the hypothesis that diversity promotes stability at the county level across the nine census regions of the United States. The analysis uses county employment data from isolated counties of 5,000 to 461,000 population for years 1977 to 1985. An intercept-shift model is used to determine if the diversity/stability relationship exists. The regression model is also used to determine if individual census regions are inherently more stable and whether certain regions are more stable over time. An Adjusted Minimum Requirements index was used to measure diversity while stability was measured with the Regional Economic Instability index. The results from this research show no significant relationship between diversity and stability. When looking at the results across time, the regions behaved similarly and became inherently more stable during economic upswings.M.S. (Master of Science

    Sir John Davies' law reports and the consolidation of the Tudor conquest of Ireland

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    SIGLEAvailable from British Library Document Supply Centre- DSC:D70535/81 / BLDSC - British Library Document Supply CentreGBUnited Kingdo
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