Relationship between rs841 polymorphism in the 3'-UTR of GCH1 gene and vascular function measured as endothelium dependent FMD (panel A) and endothelium independent NMD) (panel B).

<p>AA indicates frequent homozygote, Aa - heterozygote, aa - rare homozygote.</p

Relationship between studied polymorphisms and plasma vWF concentration.

<p>Relationship to polymorphisms forming haplotype block 1 (panel A) and haplotype block 2 (panel B) is demonstrated. Statistical significance of linear regression: * p<0.05.</p

Models of association of GCH1 gene polymorphisms with outcome variables, accounting for current smoking, kidney dysfunction^* and diabetes duration covariates.

<p>Models of association of GCH1 gene polymorphisms with outcome variables, accounting for current smoking, kidney dysfunction^{<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0108587#nt104" target="_blank">*</a>} and diabetes duration covariates.</p

Clinical characteristics of the studied T2DM patients.

<p>Clinical characteristics of the studied T2DM patients.</p

Association of individual GCH1 gene polymorphisms with outcome variables.

<p>Association of individual GCH1 gene polymorphisms with outcome variables.</p

Relationship between studied polymorphisms and plasma MDA concentration measured by mass-spec analysis.

<p>Relationship to polymorphisms forming haplotype block 1 (panel A) and haplotype block 2 (panel B) is demonstrated. Statistical significance of linear regression: * p<0.05; ** p<0.01.</p