5 research outputs found
Speed of sound index for liver steatosis estimation: a reliability study in normal subjects
PURPOSENon-alcoholic fatty liver disease (NAFLD) is the most widespread type of chronic liver disease in the Western countries. Ultrasound (US) is widely used for NAFLD staging. The Resona 7 US system (Mindray Bio-Medical Electronics Co., Ltd.) includes an image optimization and speed of ultrasound-related feature, Sound Speed Index (SSI). SSI is applied in a region of interest (ROI) that could potentially aid in tissue characterization. The purpose of this study is to evaluate the reliability of SSI on various examination parameters on normal subjects.METHODSTwenty normal subjects were examined by two radiologists performing SSI measurements in the liver in different ROI depths and sizes. Intraclass correlation coefficient (ICC) was calculated to measure intra- and inter-observer variability and inter-ROI variability.RESULTSFor all ROIs and both radiologists, the mean inter-observer ICC was 0.62 and the mean intraobserver ICC was 0.52 and 0.79. The mean SSI values for all ROIs and examiners were in the range 1528.79-1540.16 m/s.CONCLUSIONThe results indicate that SSI can lead to reliable measurements on normal subjects, independent of ROI size but dependent on ROI placement. More studies processing NAFLD patients, utilizing reference methods of liver fat quantification either for reliability or correlation with SSI, should be performed to further investigate the relevance of the SSI as a potential biomarker in clinical practice for liver steatosis grading
A diagnostic approach of non-alcoholic fatty liver disease with a machine learning model using parameters derived from ultrasound B-mode examination
Deep learning networks on chronic liver disease assessment with fine-tuning of shear wave elastography image sequences
Assessment of biopsy-proven liver fibrosis by two-dimensional shear wave elastography : an individual patient data based meta-analysis
Assessment of biopsy-proven liver fibrosis by two-dimensional shear wave elastography: An individual patient data-based meta-analysis
Two-dimensional shear wave elastography (2D-SWE) has proven to be
efficient for the evaluation of liver fibrosis in small to
moderate-sized clinical trials. We aimed at running a larger-scale
meta-analysis of individual data. Centers which have worked with
Aixplorer ultrasound equipment were contacted to share their data.
Retrospective statistical analysis used direct and paired receiver
operating characteristic and area under the receiver operating
characteristic curve (AUROC) analyses, accounting for random effects.
Data on both 2D-SWE and liver biopsy were available for 1,134 patients
from 13 sites, as well as on successful transient elastography in 665
patients. Most patients had chronic hepatitis C (n=379), hepatitis B
(n=400), or nonalcoholic fatty liver disease (n=156). AUROCs of 2D-SWE
in patients with hepatitis C, hepatitis B, and nonalcoholic fatty liver
disease were 86.3%, 90.6%, and 85.5% for diagnosing significant
fibrosis and 92.9%, 95.5%, and 91.7% for diagnosing cirrhosis,
respectively. The AUROC of 2D-SWE was 0.022-0.084 (95% confidence
interval) larger than the AUROC of transient elastography for diagnosing
significant fibrosis (P=0.001) and 0.003-0.034 for diagnosing cirrhosis
(P=0.022) in all patients. This difference was strongest in hepatitis B
patients. Conclusion: 2D-SWE has good to excellent performance for the
noninvasive staging of liver fibrosis in patients with hepatitis B;
further prospective studies are needed for head-to-head comparison
between 2D-SWE and other imaging modalities to establish
disease-specific appropriate cutoff points for assessment of fibrosis
stage. (Hepatology 2018;67:260-272)