1 research outputs found
Ultrathin TiO<sub>2</sub> Coatings via Atomic Layer Deposition Strongly Improve Cellular Interactions on Planar and Nanotubular Biomedical Ti Substrates
This work aims to investigate the chemical and/or structural
modification
of Ti and Ti-6Al-4V (TiAlV) alloy surfaces to possess even more favorable
properties toward cell growth. These modifications were achieved by
(i) growing TiO2 nanotube layers on these substrates by
anodization, (ii) surface coating by ultrathin TiO2 atomic
layer deposition (ALD), or (iii) by the combination of both. In particular,
an ultrathin TiO2 coating, achieved by 1 cycle of TiO2 ALD, was intended to shade the impurities of F- and V-based
species in tested materials while preserving the original structure
and morphology. The cell growth on TiO2-coated and uncoated
TiO2 nanotube layers, Ti foils, and TiAlV alloy foils were
compared after incubation for up to 72 h. For evaluation of the biocompatibility
of tested materials, cell lines of different tissue origin, including
predominantly MG-63 osteoblastic cells, were used. For all tested
nanomaterials, adding an ultrathin TiO2 coating improved
the growth of MG-63 cells and other cell lines compared with the non-TiO2-coated counterparts. Here, the presented approach of ultrathin
TiO2 coating could be used potentially for improving implants,
especially in terms of shading problematic F- and V-based species
in TiO2 nanotube layers