9 research outputs found
New insights into the genetic etiology of Alzheimer's disease and related dementias
- Author
- Aaltonen L.
- Aaltonen V.
- Aarsland Dag
- Aavikko M.
- Abalos M.S.
- Abdelnour Carla
- Abner E.
- Abraham R.
- Adams H.
- Adams P.M.
- Adarmes-Gómez A.
- Adarmes-Gómez A.D.
- Aguilera N.
- Aguilera N.
- Aguirre A.
- Ahmad S.
- Akinyemi R.O.
- Al-Chalabi A.
- Alarcón-Martín Emilio
- Albert M.S.
- Albin R.L.
- Alcolea Daniel
- Alegret Montserrat
- Ali M.
- Allen M.
- Allende I.R.
- Alonso M.D.
- Alonso M.D.
- Alvarez I.
- Alvarez L.
- Amer-Ferrer G.
- Amin N.
- Amouyel Philippe
- Anastasiou A.
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- Teng E.
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- Tuomi T.
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- Tuovila O.
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- Turunen J.A.
- Tybjærg-Hansen A.
- Tzourio C.
- Tárraga L.
- Uitterlinden A.
- Ullgren A.
- Ulstein I.
- Universitat Autònoma de Barcelona
- Uphill J.
- Usiskin K.
- Uusitalo H.
- Uusitalo-Järvinen H.
- Vacca A.
- Vainio S.
- Valero S.
- Valladares O.
- Valladares O.
- van Adelsberg J.
- Van Deerlin V.M.
- van den Bussche H.
- van der Flier Wiesje M
- van der Lee S.J.
- van der Lugt A.
- van Duijn C.M.
- van Eldik L.J.
- van Lent D.M.
- van Rooij J.
- van Swieten J.
- Vance J.
- Vandenberghe R.
- Vardarajan B.N.
- Vardy E.
- Vargas L.
- Vassar R.
- Verhey F.
- Vicente M. P.
- Vidal J.S.
- Vigo-Ortega R.
- Vigo-Ortega R.
- Vilas R.H.
- Vinters H.V.
- Virolainen P.
- Vivancos L.
- Vogelgsang J.
- Vojinovic D.
- Vonsattel J.P.
- Voutilainen M.
- Vyhnalek M.
- Wadhawan S.
- Wagner M.
- Wallon D.
- Wang C.
- Wang L.S.
- Wang R.
- Wang Y.
- Warden D.
- Waring J.
- Waring J.
- Warner N.
- Warren J.D.
- Waterworth D.
- Weber H.
- Weinhold L.
- Weinstein G.
- Weintraub S.
- Welsh-Bohmer K.A.
- Whelan C.
- Whitehead P.L.
- Wichmann H.E.
- Wigmore E.
- Wijsman E.M.
- Wilcock G.
- Wilhelmsen K.C.
- Williams A.
- Williams B.
- Williams D.
- Williams J.
- Williamson J.
- Wilms H.
- Wiltfang J.
- Windle G.
- Wingo T.S.
- Wisniewski T.
- Wittfeld K.
- Woltjer R.L.
- Wong R.
- Woods B.
- Woon M.
- Wright C.B.
- Wu C.K.
- Wu Y.
- Xia T.h.
- Xu E.
- Xu F.
- Yanek L.
- Yang Q.
- Yang Y.
- Yannakoulia M.
- Yaqub A.
- Younkin S.G.
- Yu C.E.
- Yu L.
- Zare H.
- Zhang X.
- Zhang Y.
- Zhao Y.
- Zhao Y.
- Zhou W.
- Zhu C.
- Zhu X.
- Ziemann A.
- Zoia C.P.
- Zompo M.D.
- Zulaica M.
- Álvarez V.
- Publication venue
- Publication date
- 01/01/2022
- Field of study
Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele
Restoration of Drug Sensitivity by Nitroxazepine Hydrochloride in P388 Murine Leukemia Cells Resistant to Adriamycin
- Author
- Publication venue
- 'Mary Ann Liebert Inc'
- Publication date
- Field of study
Recommended from our members
The efficacy of adjuvant platinum-based chemotherapy in Stage I uterine papillary serous carcinoma (UPSC)
- Author
- Publication venue
- Elsevier Inc
- Publication date
- 01/01/2005
- Field of study
To determine the efficacy of adjuvant platinum-based chemotherapy in Stage I uterine papillary serous carcinoma (UPSC).
A retrospective multi-institutional investigation was performed to identify surgically staged patients with Stage I UPSC who were (1) treated after surgery with 3–6 courses of platinum-based chemotherapy without radiation from 1990–2003, and (2) followed for a minimum of 12 months, or until recurrence.
Six patients (IA—2, IB—3, IC—1) were treated with carboplatin (AUC 6) or cisplatin (50 mg/m
2) alone. One patient recurred to the vagina, was treated with chemo-radiation, and is alive and well at 122 months. One patient recurred to the lung, liver, and brain, and died of disease at 24 months. The remaining 4 patients are alive with no evidence of disease 15–124 months (mean 62 months) after treatment. Two patients (IB-1, IC-1) were treated with cisplatin (50 mg/m
2) and cyclophosphamide (1000 mg/m
2), and both are alive and well with no evidence of disease 75 and 168 months after treatment. Twenty-one patients (IA—5, IB—13, IC—3) were treated with a combination of carboplatin (AUC 6) and paclitaxel (135 mg/m
2–175 mg/m
2). One patient recurred to the vagina after 3 cycles of carboplatin/paclitaxel, and was treated with chemo-radiation. She is now without evidence of disease 10 months after treatment. At present, all 21 patients with Stage I UPSC treated following surgical staging with carboplatin/paclitaxel chemotherapy are alive and well with no evidence of disease 10–138 months (mean 41 months) after treatment.
Combination carboplatin/paclitaxel chemotherapy following surgery is effective in the treatment of Stage I UPSC
Adnexal Masses in Premenopausal Reproductive Age Women
- Author
- Publication venue
- 'Bentham Science Publishers Ltd.'
- Publication date
- Field of study
Indirect Compensation as a Tunnel for Executives' Perquisite Consumption: The Role of Large Shareholders and Disciplinary Systems
- Author
- Abrahamson E.
- Baysinger B.
- Beasley M.S.
- Bebchuk L.A.
- Bebchuk L.A.
- Bethel J.E.
- Boeker W.
- Boyd B.K.
- Chalmers J.M.R.
- Chhibber P.K.
- Coff R.
- Coughlan A.T.
- Cronqvist H.
- David P.
- Demsetz H.
- Douglas E.J.
- Douma S.
- Fama E.F.
- Fama E.F.
- Gedajlovic E.R.
- Gibbs P.A.
- Grossman S.J.
- Hanlon M.
- Haubrich J.G.
- Hill C.W.
- Hofstede G.
- Holderness C.G.
- Jensen M.C.
- Johnson R.A.
- Kassinis G.
- Khanna T.
- Kochhar R.
- Lambert R.
- Lee P.M.
- McConnell J.
- McGuire J.W.
- McMullen D.A.
- Morck R.
- Murphy K.J.
- Pasban M.R.
- Pavlik E.
- Ramaswamy K.
- Santerre R.E.
- Schoonhoven C.B.
- Shleifer A.
- Sundaramurthy C.
- Thomsen S.
- Tihanyi L.
- Tosi H.L., Jr
- Walsh J.P.
- Weisbach M.S.
- Yafeh Y.
- Yeh Y.H.
- Zahra S.A.
- Zajac E.J.
- 고광수
- 김경묵
- 김경묵
- 박정윤
- 박헌준
- 이경태
- 이태호
- 최병규
- Publication venue
- 'Korean Society of Strategic Management'
- Publication date
- Field of study
The Role of Imaging in the Evaluation of Adnexal Masses
- Author
- Abbas A.M.
- Abbas A.M.
- Abbas A.M.
- Abbas A.M.
- Andrew E.R.
- Baird D.D.
- Bar-On S.
- Berrington de González A.
- Bouyer J.
- Brawn J.
- Brenner D.J.
- Brown D.L.
- Christopher J. Cole
- Dialani V.
- Dinushi S.P.
- Dogra V.
- Doubilet P.M.
- Granberg S.
- Guerriero S.
- Hiller N.
- Jacobs I.
- Jain K.A.
- Jain K.A.
- Jasmine J. Han
- Jermy K.
- Jermy K.
- Jung S.E.
- Jung S.E.
- Kawamoto S.
- Kido A.
- Killackey M.A.
- Kim J.S.
- Kim S.H.
- Kirk S. Russell
- Kurjak A.
- Kurman R.J.
- Lareau S.M.
- Lauterbur P.C.
- Lee K.
- Lentz G.M.
- Levine D.
- Malde H.M.
- Mansour G.M.
- Mashiach R.
- McWilliams G.D.
- Middleton W.D.
- Modesitt S.C.
- Mohaghegh P.
- Nizar K.
- Oltmann S.C.
- Outwater E.K.
- Pannu H.K.
- Patel M.D.
- Patel M.D.
- Patel M.D.
- Patel M.D.
- Patel M.D.
- Patel M.D.
- Pavlik E.J.
- Peipert J.F.
- Ray J.G.
- Rha S.E.
- Sample W.F.
- Siegel R.
- Singh A.
- Smith-Bindman R.
- Sohaib S.A.
- Tanaka Y.O.
- Tanos V.
- Timmerman D.
- Timor-Tritsch I.E.
- Utrilla-Layna J.
- Van Calster B.
- Van Holsbeke C.
- Vegetti W.
- Wiesenfeld H.C.
- Wilkinson C.
- Yeong Y.Y.
- Publication venue
- 'Bentham Science Publishers Ltd.'
- Publication date
- Field of study
Neuropeptide and Kinin Antagonists
- Author
- A. Ebersberger
- A. Fox
- A. Opree
- A.D. Bennett
- A.M. Patwardhan
- A.W. Duggan
- A.W. Duggan
- B. Aubel
- B. Chopra
- B. Hutchins
- B. Norman
- B. Schutz
- B.H. Gabra
- B.H. Gabra
- C. Felipe De
- C. Garret
- C. Jones
- C. Molander
- C. Patte-Mensah
- C.M. Hingten
- D. Julius
- D. Julius
- D. Levy
- D. Levy
- D. Nohr
- D. Rossum Van
- D. Smith
- D.A. Cabrini
- D.J. Goldstein
- D.J. Goldstein
- D.J. Williamson
- D.J. Williamson
- D.J. Williamson
- D.J. Williamson
- D.L. Hay
- D.L. Hay
- D.M. Raidoo
- D.R. Poyner
- D.S. Kang
- D.S. Kang
- D.S. Su
- E.J. Bowen
- E.K. Dziadulewicz
- E.M. Garry
- E.S. Fernandes
- F. Boix
- F. Guzman
- F. Marceau
- F. Marceau
- F.A. White
- G. Bregola
- G. Morissette
- G.A. Block
- G.M. Burgess
- G.R. Seabrook
- G.S. Mason
- H. Eisenbarth
- H. Ichikawa
- H. Mansikka
- H. Mansikka
- H. Natsugari
- H. Nawa
- H. Wang
- H.A. Baptista
- H.E. Connor
- H.H. Chuang
- H.X. Liu
- I. Juranek
- I. Pavlik
- I.J. Beresford
- I.J. Russell
- I.R. Matthew
- J. Fernihough
- J. Ferreira
- J. Ferreira
- J. Ferreira
- J. Gougat
- J. Olesen
- J. Tajti
- J. Troger
- J.A. Borkowki
- J.B. Calixto
- J.B. Calixto
- J.B. Calixto
- J.B. Pesquero
- J.C. Hershey
- J.D. Leah
- J.F. Hess
- J.H. Jang
- J.I. Nagy
- J.L. Bellamy
- J.L. Henry
- J.L. Li
- J.M. Laird
- J.M. Laird
- J.M. Laird
- J.S. Han
- J.S. Mogil
- J.T. Lu
- K. Ren
- K. Rudolf
- K. Sakai
- K.A. Petersen
- K.K. Tan
- K.K.C. Tan
- K.R. Oliver
- K.R. Oliver
- K.R. Oliver
- L. Awawdeh
- L. Edvinsson
- L. Edvinsson
- L. Edvinsson
- L. Martinez-Caro
- L. Seguin
- L.A. Phebus
- L.A. Urban
- L.C. Yu
- L.E. Anderson
- L.H. Lassen
- L.M. Leeb-Lundberg
- L.M. Neckers
- L.N. Fang
- M. Ashina
- M. Coudore-Civiale
- M. Mazzuferi
- M. Samsam
- M.A. Cascieri
- M.A. Daemen
- M.A. Henry
- M.A. Sabino
- M.B. Max
- M.G. Bock
- M.G. Rosenfeld
- M.H. Rashid
- M.I. Gonzalez
- M.J. Cumberbatch
- M.J. Cumberbatch
- M.J. Field
- M.J. Field
- M.J. Levy
- M.J. Moreno
- M.J. Schwei
- M.J.M. Fischer
- M.R. Wood
- N. Aiyar
- N.M. Rupniak
- N.M. Rupniak
- N.M. Rupniak
- N.M.J. Rupniak
- N.M.J. Rupniak
- N.P. Kerezoudis
- O. Lofgren
- P. Boscan
- P. Ganju
- P. Honore
- P. Lopes
- P. Shembalkar
- P. Xu
- P.B. Simpson
- P.G. McLean
- P.J. Goadsby
- P.K. Ferreira
- P.W. Mantyh
- P.W. Mantyh
- P.W. Mantyh
- P.W. Wacnik
- Q.P. Ma
- R Hargreaves
- R. Ambalavanar
- R. Couture
- R. Morris
- R. Muff
- R.A. Cridland
- R.A. Daines
- R.A. Dionne
- R.A. Dionne
- R.A. Kinloch
- R.D. Piper
- R.G. Hill
- R.G. Hill
- R.K. Conley
- R.M. Navari
- R.Q. Sun
- R.R. Reinhardt
- R.W. Ransom
- S. Ballet
- S. Boyce
- S. Boyce
- S. Boyce
- S. Gebre-Medhin
- S. Iyengar
- S. Just
- S. McLean
- S. Okano
- S. Tanaka
- S.C. Cruwys
- S.D. Brain
- S.D. Brain
- S.G. Amara
- S.L. Shepheard
- S.L. Shepheard
- S.P. Hunt
- T. Goto
- T. Hokfelt
- T. Hokfelt
- T. Hokfelt
- T. King
- T. Riediger
- T. Tachibana
- T. Yamamoto
- T. Yasuda
- T.E. Salt
- T.E.O. Schubert
- T.J. Richie
- U. Hanesch
- V. Gallai
- V. Kayser
- V. Limmroth
- V. Neugebauer
- V. Radhakrishnan
- V. Radhakrishnan
- V. Sergeyev
- V. Sibilia
- V. Vellani
- V.S. Seybold
- W. Binder
- W. Ma
- W. Ma
- Y. Kuraishi
- Y. Oh-hashi
- Y. Okayama
- Z. Dlamini
- Z. Ye
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2006
- Field of study
Branching Morphogenesis in Vertebrate Neurons
- Author
- A. Acebes
- A. Augsburger
- A. Davy
- A. Hall
- A. Inoue
- A. Kossel
- A. Kruttgen
- A. Leingartner
- A. Markus
- A. Matus
- A. Matus
- A. Matus
- A. Pavlik
- A. Prochiantz
- A. Ridley
- A. Shimada
- A. Tabuchi
- A.F. Schinder
- A.H. Kossel
- A.J. Furley
- A.J. Ridley
- A.K. Butler
- A.K. Lewis
- A.K. McAllister
- A.K. McAllister
- A.K. McAllister
- A.K. McAllister
- A.K. McAllister
- A.L. Bishop
- A.L. Kolodkin
- A.L. Roskies
- A.M. Ainsztein
- A.M. Craig
- A.M. Craig
- A.M. Davies
- A.M. Davies
- A.M. Davies
- A.M. Harvey
- A.M. Sydor
- A.M. Turing
- A.P. Braun
- A.R. Kriegstein
- A.S. Leonard
- A.S. Nilsson
- A.T. Schaefer
- A.Y. Deutch
- A.Y. Nakayama
- A.Y. Nakayama
- B. Berninger
- B. Berninger
- B. Chamak
- B. Clendening
- B. Clendening
- B. Knoll
- B. Lorn
- B. Monschau
- B. Winckler
- B. Winckler
- B.A. Barres
- B.D. Johnson
- B.D. Philpot
- B.J. Dickson
- B.S. McEwen
- B.W. Sheasby
- C. Albertinazzi
- C. Faivre-Sarrailh
- C. Faivre-Sarrailh
- C. Faivre-Sarrailh
- C. Faivre-Sarrailh
- C. Gaiddon
- C. Labelle
- C. Sanchez
- C. Sotelo
- C. Strohmaier
- C. Wetmore
- C.A. Baptista
- C.B. Chien
- C.C. Tsui
- C.D. McCaig
- C.D. Toran-Allerand
- C.E. Henderson
- C.G. Dotti
- C.H. Lin
- C.M. Niell
- C.M. Waterman-Storer
- C.S. Bartheld van
- C.S. Bartheld van
- C.S. Goodman
- C.S. Goodman
- C.S. Woolley
- D. Bray
- D. Bray
- D. Higgins
- D. Hogan
- D. Kryl
- D. Kuhl
- D. Lindholm
- D. Lindholm
- D. Lindholm
- D. Lindholm
- D. Purves
- D. Purves
- D. Purves
- D. Purves
- D. Vactor Van
- D. Vactor Van
- D. Xu
- D.A. Vouyiouklis
- D.D. O’Leary
- D.D. O’Leary
- D.D. O’Leary
- D.E. Hillman
- D.E. Hillman
- D.E. Hillman
- D.E. Hillman
- D.E. Hillman
- D.F. Condorelli
- D.G. Wells
- D.H. Baird
- D.H. Baird
- D.H. Baird
- D.J. Goldberg
- D.J. Mackay
- D.J. Mackay
- D.J. Zou
- D.K. Simon
- D.L. Foletti
- D.L. Morgan
- D.M. Kingsley
- D.M. Suter
- D.M. Suter
- D.M. Suter
- D.M. Valenzuela
- D.R. Kaplan
- D.R. Kaplan
- D.S. Campbell
- D.S. Middlemas
- D.V. Vactor Van
- D.W. Burmeister
- D.W. Rickman
- E. Castren
- E. D’Angelo
- E. Gould
- E. Gould
- E. Mohr
- E. Nedivi
- E. Nedivi
- E. Nedivi
- E. Nedivi
- E. Ruoslahti
- E. Ruoslahti
- E. Ruoslahti
- E. Ruoslahti
- E. Tanaka
- E. Thies
- E. Tongiorgi
- E. Tongiorgi
- E.G. Jones
- E.J. Huang
- E.M. Quinlan
- E.M. Quinlan
- E.M. Tanaka
- E.S. Lein
- E.T. Coffey
- E.W. Dent
- E.W. Dent
- F. Angenstein
- F. Bradke
- F. Bradke
- F. Bradke
- F. Lafont
- F. Lafont
- F. Lafont
- F. Lamballe
- F. Lamballe
- F. Lamballe
- F. Polleux
- F. Polleux
- F. Sato
- F. Solomon
- F. Solomon
- F. Stastny
- F. Yang
- F. Zafra
- F. Zafra
- F.J. Ahmad
- F.J. Ahmad
- F.J. Diez-Guerra
- F.J. Diez-Guerra
- F.J. Diez-Guerra
- F.J. McNally
- F.L. Watson
- F.M. Benes
- G. Audesirk
- G. Banker
- G. Drewes
- G. Gallo
- G. Gallo
- G. Gallo
- G. Kadmon
- G. Martinez
- G. Mellitzer
- G. Morfini
- G. Morfini
- G. Perides
- G. Pfeiffer
- G. Ruthel
- G. Szebenyi
- G. Szebenyi
- G. Vrbova
- G.A. Banker
- G.A. Banker
- G.G. Borisy
- G.G. Turrigiano
- G.L. Lyford
- G.M. Edelman
- G.M. Edelman
- G.R. Lewin
- G.S. Naeve
- G.S. Withers
- G.Y. Wu
- G.Y. Wu
- H. Bito
- H. Chen
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2005
- Field of study
New insights into the genetic etiology of Alzheimer’s disease and related dementias
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele. © 2022, The Author(s)