70 research outputs found
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Evaluation of “Codeve” methodology for teaching npd to virtual design teams
Studies on the effectiveness of New Product Development (NPD) in countries of partner organizations of EGPR (European Global Product Realisation) course discovered that the end phases of the process are most challenging. These are identification of market needs on one end and commercialization on the other. CODEVE (COllaborative DEsign in Virtual Environment) teaching methodology is developed within EGPR course. EGPR is joint educational project of four European universities running since 2004. CODEVE is tested through the Erasmus+ funded project called NARIP (Networked Activities for Realization of Innovative Products). The goal of developing this teaching methodology was to establish suitable means by which students can learn NPD process and how to implement it in their professional career. NARIP project is funded by EU over three years to develop, test and implement this methodology within partner academic institutions from the UK, Croatia, Slovenia and Hungary. It is expected that the recommendations resulting from this activity will be implemented in academia and industry across Europe and help companies to improve their NPD process. This paper presents findings of the student surveys from NARIP projects hosted by Zagreb and Budapest in 2015 and 2016 respectively. The study analyses the effectiveness of the NPD process, the engagement of students, knowledge generation of staff and other aspects of the performed NPD process. The analysis lead to recommendations of improving the CODEVE methodology which will be finally tested in the EGPR project hosted in the UK in 2017
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Development of methodology for distributed collaborative design environment
This paper describes the CODEVE (COllaborative DEsign in Virtual Environment) methodology developed in a joint educational project of four European universities called NARIP (Networked Activities for Realization of Innovative Products). The ultimate goal of the NARIP NPD course is to develop a concept and produce a physical product prototype within one academic semester. In order to expose students to real life situations the prototype is being produced in close collaboration with an industrial partner. Elements of the NARIP course comprise: (1) project definition-according to agreement with the industrial partner, (2) lectures composed and adapted to address the specific needs of the current project and which are equally distributed to partner universities, (3) project work monitored by academics, with three distinct phases and review points, and (4) the final workshop that includes prototype manufacturing, assembly and testing, final presentation and exhibition. The paper presents the structure and details of the developed methodology as well as an overview of the course development history. The core of the CODEVE methodology is a set of comprehensive guidelines for students and teachers that are specially adapted and focused to the issues and problems that arise in distributed collaborative multidisciplinary design projects. The methodology focuses on management of complex projects, emphasizing the importance of research phases, prompt clarification of any issues and balanced distribution of project tasks. The methodology also promotes the use of various virtual/on-line collaboration tools to foster discussion and exchange of 3D sketches and models
Recommended from our members
Development of methodology for distributed collaborative design environment
This paper describes the CODEVE (COllaborative DEsign in Virtual Environment) methodology developed in a joint educational project of four European universities called NARIP (Networked Activities for Realization of Innovative Products). The ultimate goal of the NARIP NPD course is to develop a concept and produce a physical product prototype within one academic semester. In order to expose students to real life situations the prototype is being produced in close collaboration with an industrial partner. Elements of the NARIP course comprise: (1) project definition-according to agreement with the industrial partner, (2) lectures composed and adapted to address the specific needs of the current project and which are equally distributed to partner universities, (3) project work monitored by academics, with three distinct phases and review points, and (4) the final workshop that includes prototype manufacturing, assembly and testing, final presentation and exhibition. The paper presents the structure and details of the developed methodology as well as an overview of the course development history. The core of the CODEVE methodology is a set of comprehensive guidelines for students and teachers that are specially adapted and focused to the issues and problems that arise in distributed collaborative multidisciplinary design projects. The methodology focuses on management of complex projects, emphasizing the importance of research phases, prompt clarification of any issues and balanced distribution of project tasks. The methodology also promotes the use of various virtual/on-line collaboration tools to foster discussion and exchange of 3D sketches and models
Resistance to DNA Damaging agents produced invasive phenotype of rat glioma cells-characterization of a new in vivo model
Chemoresistance and invasion properties are severe limitations to efficient glioma therapy. Therefore, development of glioma in vivo models that more accurately resemble the situation observed in patients emerges. Previously, we established RC6 rat glioma cell line resistant to DNA damaging agents including antiglioma approved therapies such as 3-bis(2-chloroethyl)-1-nitrosourea (BCNU) and temozolomide (TMZ). Herein, we evaluated the invasiveness of RC6 cells in vitro and in a new orthotopic animal model. For comparison, we used C6 cells from which RC6 cells originated. Differences in cell growth properties were assessed by real-time cell analyzer. Cells’ invasive potential in vitro was studied in fluorescently labeled gelatin and by formation of multicellular spheroids in hydrogel. For animal studies, fluorescently labeled cells were inoculated into adult male Wistar rat brains. Consecutive coronal and sagittal brain sections were analyzed 10 and 25 days post-inoculation, while rats’ behavior was recorded during three days in the open field test starting from 25th day post-inoculation. We demonstrated that development of chemoresistance induced invasive phenotype of RC6 cells with significant behavioral impediments implying usefulness of orthotopic RC6 glioma allograft in preclinical studies for the examination of new approaches to counteract both chemoresistance and invasion of glioma cells
Production Ratios of Strange Baryons from QGP with Diquarks
Assuming that vector and scalar diquarks exist in the Quark-Gluon Plasma near
the critical temporature , baryons can be produced through the processes
of quarks and diquarks forming baryon states. Ratios of different
baryons can be estimated through this method, if such kind of QGP with diquarks
can exists.Comment: Correct some expressions of equation
Association between the Cytotoxic T-Lymphocyte Antigen 4 +49G > A polymorphism and cancer risk: a meta-analysis
<p>Abstract</p> <p>Background</p> <p>As a key gene in the immunosurveillance of cell malignancy, Cytotoxic T-lymphocyte antigen 4 (CTLA-4 is an important negative regulator of T cell activation and proliferation. The CTLA-4 +49G > A polymorphism is one of the most commonly studied polymorphisms in this gene due to its association with cancer risks, but previous results have been conflicting.</p> <p>Methods</p> <p>We preformed a meta-analysis using 22 eligible case-control studies (including 32 datasets) with a total of 11,273 patients and 13,179 controls to summarize the existing data on the association between the <it>CTLA-4 </it>+49G > A polymorphism and cancer risk.</p> <p>Results</p> <p>Compared with the common <it>CTLA-4 </it>+49G > A GG genotype, the carriers of variant genotypes (<it>CTLA-4 </it>+49 GC/CC) had a 1.24-fold elevated risk of cancer (95% CI = 1.18-1.32, <it>P </it>< 0.05) under the dominant genetic model, as estimated using a fixed effect model. The effect of the <it>CTLA-4 </it>+49G > A polymorphism was further evaluated using stratification analysis. In four breast cancer studies, patients with the variant genotypes had a significantly increased risk of breast cancer (OR = 1.31, 95% CI = 1.17-1.48, <it>P </it>< 0.00001). A similar result was found in three skin cancer studies (OR = 1.30, 95% CI = 1.10-1.52, <it>P </it>= 0.001). In 26 solid tumor studies, subjects with the variant genotypes had a significantly higher risk of developing solid tumors (OR = 1.25, 95% CI = 1.18-1.33, <it>P </it>< 0.00001) compared with the 6 non-solid tumor studies (OR = 1.08, 95% CI = 0.79-1.48, <it>P </it>= 0.62). Patients with variant genotypes had significantly increased risk of non-epithelial tumors and epithelial tumors, with ORs of 1.23 (95% CI = 1.14-1.32, <it>P </it>< 0.00001) and 1.29 (95% CI = 1.17-1.41, <it>P </it>< 0.00001), respectively. It was also demonstrated that the increased risk of cancer associated with <it>CTLA-4 </it>+49G > A variant genotypes was more pronounced in Caucasians (OR = 1.29, 95% CI = 1.13-1.47, <it>P </it>= 0.0002), Asians (OR = 1.23, 95% CI = 1.16-1.32, <it>P </it>< 0.00001) and Chinese (OR = 1.23, 95% CI = 1.15-1.31, <it>P </it>< 0.00001).</p> <p>Conclusion</p> <p>Our meta-analysis suggests that the <it>CTLA-4 </it>+49G > A polymorphism genotypes (GA + AA) might be associated with an increased risk of cancer, especially in Caucasians and Chinese.</p
How local governments can increase the social and economic participation of people with disability
This resource provides a national framework for local governments across Australia which recognises that responses need to be local, needs-based and fit for purpose. The key aim of the resource is to build awareness, understanding and knowledge about how to plan and implement strategies and programs to increase the social and economic participation of people with disability
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