4 research outputs found
ΠΠΈΡΠ΅ΡΠ½Π°Ρ ΠΌΠΈΠΊΡΠΎΠ±ΠΈΠΎΡΠ° ΠΈ Π°Π»Π»Π΅ΡΠ³ΠΈΡ. ΠΡΠΎ- ΠΈ ΠΏΡΠ΅Π±ΠΈΠΎΡΠΈΠΊΠΈ Π² ΠΏΡΠΎΡΠΈΠ»Π°ΠΊΡΠΈΠΊΠ΅ ΠΈ Π»Π΅ΡΠ΅Π½ΠΈΠΈ Π°Π»Π»Π΅ΡΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ
Intestinal microbiota is the factor that identifies considerably the human health. The impact of the microbial factor on a child begins long before his birth. Children have certain features in forming of immune response and intestinal microbiocenosis even before birth. Decline in diversity of intestinal microbiota is common in children with allergic disease even during first months of life, before allergic pathology development. Capabilities for microbiota development adjustment are sufficiently restricted. However it is clinically proven that early (within the first hours of life) breastfeeding attachment, breastfeeding itself within at least first 6 months of life, the use of prebiotics in milk formulas as well as the use of probiotics can give positive results on allergy management. In this review we present results of recent metaanalyses and consensus papers of international medical communities about use of probiotics and prebiotics in prevention and treatment of allergic diseases. Despite great scientific and practical interest to this topic, authors of metaanalyses bring our attention to the lack of evidence-based clinical trials.ΠΠΈΠΊΡΠΎΠ±ΠΈΠΎΡΠ° ΠΊΠΈΡΠ΅ΡΠ½ΠΈΠΊΠ° ΡΠ²Π»ΡΠ΅ΡΡΡ ΡΠ°ΠΊΡΠΎΡΠΎΠΌ, Π² Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎΠΉ ΡΡΠ΅ΠΏΠ΅Π½ΠΈ ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΡΡΠΈΠΌ Π·Π΄ΠΎΡΠΎΠ²ΡΠ΅ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ°. ΠΠΎΠ·Π΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ Π½Π° ΡΠ΅Π±Π΅Π½ΠΊΠ° ΠΌΠΈΠΊΡΠΎΠ±Π½ΠΎΠ³ΠΎ ΡΠ°ΠΊΡΠΎΡΠ° Π½Π°ΡΠΈΠ½Π°Π΅ΡΡΡ Π·Π°Π΄ΠΎΠ»Π³ΠΎ Π΄ΠΎ ΡΠΎΠΆΠ΄Π΅Π½ΠΈΡ, ΠΈ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Π½ΡΠ΅ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΈΠΌΠΌΡΠ½Π½ΠΎΠ³ΠΎ ΠΎΡΠ²Π΅ΡΠ° ΠΈ ΠΌΠΈΠΊΡΠΎΠ±ΠΈΠΎΡΠ΅Π½ΠΎΠ·Π° ΠΊΠΈΡΠ΅ΡΠ½ΠΈΠΊΠ° Π΄Π΅ΡΠΈ ΠΈΠΌΠ΅ΡΡ Π΅ΡΠ΅ Π΄ΠΎ ΡΠΎΠΆΠ΄Π΅Π½ΠΈΡ. ΠΠ»Ρ Π΄Π΅ΡΠ΅ΠΉ Ρ Π°Π»Π»Π΅ΡΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡΠΌΠΈ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠ½ΠΎ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΠ΅ ΡΠ°Π·Π½ΠΎΠΎΠ±ΡΠ°Π·ΠΈΡ ΠΊΠΈΡΠ΅ΡΠ½ΠΎΠΉ ΠΌΠΈΠΊΡΠΎΠ±ΠΈΠΎΡΡ Π² ΠΏΠ΅ΡΠ²ΡΠ΅ ΠΌΠ΅ΡΡΡΡ ΠΆΠΈΠ·Π½ΠΈ β Π΅ΡΠ΅ Π΄ΠΎ ΡΠ°Π·Π²ΠΈΡΠΈΡ Π°Π»Π»Π΅ΡΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΠΈ. ΠΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΠΈ ΠΊΠΎΡΡΠ΅ΠΊΡΠΈΡΠΎΠ²Π°ΡΡ ΠΏΡΠΎΡΠ΅ΡΡ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΌΠΈΠΊΡΠΎΠ±ΠΈΠΎΡΡ Π΄ΠΎΡΡΠ°ΡΠΎΡΠ½ΠΎ ΠΎΠ³ΡΠ°Π½ΠΈΡΠ΅Π½Ρ, ΠΎΠ΄Π½Π°ΠΊΠΎ ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ ΡΠ°Π½Π½Π΅Π΅ (Π² ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ ΠΏΠ΅ΡΠ²ΡΡ
ΡΠ°ΡΠΎΠ² ΠΆΠΈΠ·Π½ΠΈ) ΠΏΡΠΈΠΊΠ»Π°Π΄ΡΠ²Π°Π½ΠΈΠ΅ ΠΊ Π³ΡΡΠ΄ΠΈ, Π³ΡΡΠ΄Π½ΠΎΠ΅ Π²ΡΠΊΠ°ΡΠΌΠ»ΠΈΠ²Π°Π½ΠΈΠ΅ Π² ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ ΠΊΠ°ΠΊ ΠΌΠΈΠ½ΠΈΠΌΡΠΌ ΠΏΠ΅ΡΠ²ΡΡ
6 ΠΌΠ΅Ρ ΠΆΠΈΠ·Π½ΠΈ, ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΡΠ΅Π±ΠΈΠΎΡΠΈΠΊΠΎΠ² Π² ΡΠΎΡΡΠ°Π²Π΅ Π΄Π΅ΡΡΠΊΠΈΡ
ΠΌΠΎΠ»ΠΎΡΠ½ΡΡ
ΡΠΌΠ΅ΡΠ΅ΠΉ, Π° ΡΠ°ΠΊΠΆΠ΅ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΠΏΡΠΎΠ±ΠΈΠΎΡΠΈΠΊΠΎΠ² Ρ Π΄ΠΎΠΊΠ°Π·Π°Π½Π½ΠΎΠΉ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡΡ ΠΌΠΎΠΆΠ΅Ρ Π΄Π°Π²Π°ΡΡ ΠΏΠΎΠ»ΠΎΠΆΠΈΡΠ΅Π»ΡΠ½ΡΠ΅ ΡΡΡΠ΅ΠΊΡΡ Π² ΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΠΈ ΠΏΡΠΎΡΠΈΠ»Π°ΠΊΡΠΈΠΊΠΈ Π°Π»Π»Π΅ΡΠ³ΠΈΠΈ. Π ΠΎΠ±Π·ΠΎΡΠ΅ ΠΏΡΠΈΠ²Π΅Π΄Π΅Π½Ρ ΠΎΡΠ½ΠΎΠ²Π½ΡΠ΅ Π²ΡΠ²ΠΎΠ΄Ρ ΠΏΠΎΡΠ»Π΅Π΄Π½ΠΈΡ
ΠΌΠ΅ΡΠ°Π°Π½Π°Π»ΠΈΠ·ΠΎΠ² ΠΈ ΡΠΎΠ³Π»Π°ΡΠΈΡΠ΅Π»ΡΠ½ΡΡ
Π΄ΠΎΠΊΡΠΌΠ΅Π½ΡΠΎΠ² ΠΌΠ΅ΠΆΠ΄ΡΠ½Π°ΡΠΎΠ΄Π½ΡΡ
ΠΌΠ΅Π΄ΠΈΡΠΈΠ½ΡΠΊΠΈΡ
ΡΠΎΠΎΠ±ΡΠ΅ΡΡΠ² Π² ΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΠΈ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΠΈ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΡ ΠΏΡΠΎ- ΠΈ ΠΏΡΠ΅Π±ΠΈΠΎΡΠΈΠΊΠΎΠ² Π² ΠΏΡΠΎΡΠΈΠ»Π°ΠΊΡΠΈΠΊΠ΅ ΠΈ Π»Π΅ΡΠ΅Π½ΠΈΠΈ Π°Π»Π»Π΅ΡΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ. ΠΠ΅ΡΠΌΠΎΡΡΡ Π½Π° Π±ΠΎΠ»ΡΡΠΎΠΉ Π½Π°ΡΡΠ½ΡΠΉ ΠΈ ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΈΠΉ ΠΈΠ½ΡΠ΅ΡΠ΅Ρ ΠΊ ΠΏΡΠΎΠ±Π»Π΅ΠΌΠ΅, Π°Π²ΡΠΎΡΡ ΠΌΠ΅ΡΠ°Π°Π½Π°Π»ΠΈΠ·ΠΎΠ² ΡΠΊΠ°Π·ΡΠ²Π°ΡΡ Π½Π° Π½Π΅Π΄ΠΎΡΡΠ°ΡΠΎΡΠ½ΠΎΠ΅ ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²ΠΎ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ, ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½Π½ΡΡ
Ρ ΡΠΎΠ±Π»ΡΠ΄Π΅Π½ΠΈΠ΅ΠΌ ΠΏΡΠΈΠ½ΡΠΈΠΏΠΎΠ² Π΄ΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΡΠ½ΠΎΠΉ ΠΌΠ΅Π΄ΠΈΡΠΈΠ½Ρ
ΠΠΈΠ·ΠΎΠ½ΡΠΎΠ³Π΅Π½ΠΈΠΈ ΠΌΠΈΠΊΡΠΎΠ±ΠΈΠΎΡΡ ΠΊΠΈΡΠ΅ΡΠ½ΠΈΠΊΠ° Ρ Π΄Π΅ΡΠ΅ΠΉ ΠΏΠ΅ΡΠ²ΡΡ ΠΌΠ΅ΡΡΡΠ΅Π² ΠΆΠΈΠ·Π½ΠΈ ΠΊΠ°ΠΊ ΡΠ°ΠΊΡΠΎΡ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π°ΡΠΎΠΏΠΈΠΈ
The article describes the modern views on the relationship between altered development of gut microbiota in infants and the risk of developing atopic diseases (atopic dermatitis and bronchial asthma). The studies of genetic susceptibility to atopy and the influence of epigenetic mechanisms involved in the regulation of gene expression responsible for the hyperproduction of immunoglobulin E are discussed. The characteristics of the microbiota of infants with already developed atopic diseases and children at risk of atopy are analyzed. In infants who subsequently developed atopy, the composition of gut microbiota at the birth is characterized by a reduced abundance of bifidobacteriaΒ and high content of potentially pathogenic microorganisms.Β The triggering role of active metabolites of altered microbiota on the differentiation of T-regulatoryΒ cells has been established.Β A preventive effect of optimal breastfeeding has been confirmed: meta-analyzes of recent studies indicate a link between the duration of breastfeedingΒ and a decrease in the frequency of bronchial asthma. The microbiota of breast milk contributes to the proper development of the infantβs microbiota, determines its diversity and immunomodulating action. On the basis of the conducted research, methods of targeted correction of the intestinal microbiota in children with risk of atopy can be developed.Π ΡΡΠ°ΡΡΠ΅ ΠΎΡΡΠ°ΠΆΠ΅Π½ΡΒ ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΡΠ΅ Π²Π·Π³Π»ΡΠ΄ΡΒ Π½Π° ΡΠ²ΡΠ·Ρ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΡΒ ΠΌΠΈΠΊΡΠΎΠ±ΠΈΠΎΡΡ ΠΊΠΈΡΠ΅ΡΠ½ΠΈΠΊΠ° Ρ Π΄Π΅ΡΠ΅ΠΉ ΠΏΠ΅ΡΠ²ΠΎΠ³ΠΎΒ Π³ΠΎΠ΄Π° ΠΆΠΈΠ·Π½ΠΈ Ρ ΡΠΈΡΠΊΠΎΠΌ ΡΠ°Π·Π²ΠΈΡΠΈΡ Π°ΡΠΎΠΏΠΈΡΠ΅ΡΠΊΠΈΡ
Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ (Π°ΡΠΎΠΏΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π΄Π΅ΡΠΌΠ°ΡΠΈΡΠ° ΠΈ Π±ΡΠΎΠ½Ρ
ΠΈΠ°Π»ΡΠ½ΠΎΠΉ Π°ΡΡΠΌΡ). ΠΠ±ΡΡΠΆΠ΄Π°ΡΡΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡΒ Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΎΠΉΒ ΠΏΡΠ΅Π΄ΡΠ°ΡΠΏΠΎΠ»ΠΎΠΆΠ΅Π½Π½ΠΎΡΡΠΈ ΠΊ Π°ΡΠΎΠΏΠΈΠΈ ΠΈ Π²Π»ΠΈΡΠ½ΠΈΡ ΡΠΏΠΈΠ³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ
Β ΡΠ°ΠΊΡΠΎΡΠΎΠ²Β Π½Π° ΡΠ΅Π³ΡΠ»ΡΡΠΈΡ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ Π³Π΅Π½ΠΎΠ², ΠΎΡΠ²Π΅ΡΡΡΠ²Π΅Π½Π½ΡΡ
Π·Π° Π³ΠΈΠΏΠ΅ΡΠΏΡΠΎΠ΄ΡΠΊΡΠΈΡ ΠΈΠΌΠΌΡΠ½ΠΎΠ³Π»ΠΎΠ±ΡΠ»ΠΈΠ½ΠΎΠ²Β ΠΊΠ»Π°ΡΡΠ° Π. ΠΡΠΎΠ°Π½Π°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°Π½ΡΒ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠΈ ΠΌΠΈΠΊΡΠΎΠ±ΠΈΠΎΡΡ ΠΌΠ»Π°Π΄Π΅Π½ΡΠ΅Π² Ρ ΡΠΆΠ΅ ΡΠ°Π·Π²ΠΈΠ²ΡΠΈΠΌΠΈΡΡ Π°ΡΠΎΠΏΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡΠΌΠΈ ΠΈ Π΄Π΅ΡΠ΅ΠΉ ΠΈΠ· Π³ΡΡΠΏΠΏΡ ΡΠΈΡΠΊΠ° ΠΏΠΎ Π°ΡΠΎΠΏΠΈΠΈ. Π£ Π΄Π΅ΡΠ΅ΠΉ, Π²ΠΏΠΎΡΠ»Π΅Π΄ΡΡΠ²ΠΈΠΈΒ ΡΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π²ΡΠΈΡ
Π°ΡΠΎΠΏΠΈΡ, ΡΠΎΡΡΠ°Π² ΠΌΠΈΠΊΡΠΎΠ±ΠΈΠΎΡΡ ΠΊΠΈΡΠ΅ΡΠ½ΠΈΠΊΠ° ΠΏΡΠΈ ΡΠΎΠΆΠ΄Π΅Π½ΠΈΠΈΒ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΡΠ΅ΡΡΡ ΡΠ½ΠΈΠΆΠ΅Π½Π½ΡΠΌ ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅ΠΌ Π±ΠΈΡΠΈΠ΄ΠΎΠ±Π°ΠΊΡΠ΅ΡΠΈΠΉ ΠΈ Π²ΡΡΠΎΠΊΠΈΠΌ β ΡΡΠ»ΠΎΠ²Π½ΠΎ-ΠΏΠ°ΡΠΎΠ³Π΅Π½Π½ΡΡ
ΠΌΠΈΠΊΡΠΎΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠΎΠ². Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½Π° ΡΡΠΈΠ³Π³Π΅ΡΠ½Π°Ρ ΡΠΎΠ»Ρ Π°ΠΊΡΠΈΠ²Π½ΡΡ
ΠΌΠ΅ΡΠ°Π±ΠΎΠ»ΠΈΡΠΎΠ² ΠΈΠ·ΠΌΠ΅Π½Π΅Π½Π½ΠΎΠΉ ΠΌΠΈΠΊΡΠΎΠ±ΠΈΠΎΡΡ Π² ΡΡΠ°Π½ΡΡΠΎΡΠΌΠ°ΡΠΈΠΈ Π’-ΡΠ΅Π³ΡΠ»ΡΡΠΎΡΠ½ΡΡ
ΠΊΠ»Π΅ΡΠΎΠΊ. ΠΠΎΠ΄ΡΠ²Π΅ΡΠΆΠ΄Π΅Π½Π° ΠΏΡΠ΅Π²Π΅Π½ΡΠΈΠ²Π½Π°ΡΒ ΡΠΎΠ»ΡΒ Π°Π΄Π΅ΠΊΠ²Π°ΡΠ½ΠΎΠ³ΠΎΒ Π³ΡΡΠ΄Π½ΠΎΠ³ΠΎΒ Π²ΡΠΊΠ°ΡΠΌΠ»ΠΈΠ²Π°Π½ΠΈΡ:Β ΠΌΠ΅ΡΠ°Π°Π½Π°Π»ΠΈΠ·ΡΒ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉΒ ΠΏΠΎΡΠ»Π΅Π΄Π½ΠΈΡ
Π»Π΅ΡΒ ΡΠ²ΠΈΠ΄Π΅ΡΠ΅Π»ΡΡΡΠ²ΡΡΡΒ ΠΎ ΡΠ²ΡΠ·ΠΈ ΠΏΡΠΎΠ΄ΠΎΠ»ΠΆΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ Π³ΡΡΠ΄Π½ΠΎΠ³ΠΎΒ Π²ΡΠΊΠ°ΡΠΌΠ»ΠΈΠ²Π°Π½ΠΈΡΒ ΡΠΎ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΠ΅ΠΌΒ ΡΠ°ΡΡΠΎΡΡ Π±ΡΠΎΠ½Ρ
ΠΈΠ°Π»ΡΠ½ΠΎΠΉ Π°ΡΡΠΌΡ. ΠΠΈΠΊΡΠΎΠ±ΠΈΠΎΡΠ° Π³ΡΡΠ΄Π½ΠΎΠ³ΠΎ ΠΌΠΎΠ»ΠΎΠΊΠ° ΡΠΏΠΎΡΠΎΠ±ΡΡΠ²ΡΠ΅Ρ Π°Π΄Π΅ΠΊΠ²Π°ΡΠ½ΠΎΠΌΡ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΌΠΈΠΊΡΠΎΠ±ΠΈΠΎΡΡ ΠΌΠ»Π°Π΄Π΅Π½ΡΠ°, ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΠ΅Ρ Π΅Π΅ ΡΠ°Π·Π½ΠΎΠΎΠ±ΡΠ°Π·ΠΈΠ΅ ΠΈ ΠΈΠΌΠΌΡΠ½ΠΎΠΌΠΎΠ΄ΡΠ»ΠΈΡΡΡΡΠ΅Π΅ Π΄Π΅ΠΉΡΡΠ²ΠΈΠ΅. ΠΠ° ΠΎΡΠ½ΠΎΠ²Π΅ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½Π½ΡΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ ΠΌΠΎΠ³ΡΡ Π±ΡΡΡ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠ°Π½Ρ ΠΌΠ΅ΡΠΎΠ΄Ρ Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½Π½ΠΎΠΉ ΠΊΠΎΡΡΠ΅ΠΊΡΠΈΠΈ ΠΊΠΈΡΠ΅ΡΠ½ΠΎΠΉ ΠΌΠΈΠΊΡΠΎΠ±ΠΈΠΎΡΡ Ρ Π΄Π΅ΡΠ΅ΠΉ Π³ΡΡΠΏΠΏΡ ΡΠΈΡΠΊΠ° ΠΏΠΎ Π°ΡΠΎΠΏΠΈΠΈ
Intestinal Microbiota and Allergy. Probiotics and Prebiotics in Prevention and Treatment of Allergic Diseases
Intestinal microbiota is the factor that identifies considerably the human health. The impact of the microbial factor on a child begins long before his birth. Children have certain features in forming of immune response and intestinal microbiocenosis even before birth. Decline in diversity of intestinal microbiota is common in children with allergic disease even during first months of life, before allergic pathology development. Capabilities for microbiota development adjustment are sufficiently restricted. However it is clinically proven that early (within the first hours of life) breastfeeding attachment, breastfeeding itself within at least first 6 months of life, the use of prebiotics in milk formulas as well as the use of probiotics can give positive results on allergy management. In this review we present results of recent metaanalyses and consensus papers of international medical communities about use of probiotics and prebiotics in prevention and treatment of allergic diseases. Despite great scientific and practical interest to this topic, authors of metaanalyses bring our attention to the lack of evidence-based clinical trials
Gut microbiota dysontogeniya in infants as a factor in the development of atopy
The article describes the modern views on the relationship between altered development of gut microbiota in infants and the risk of developing atopic diseases (atopic dermatitis and bronchial asthma). The studies of genetic susceptibility to atopy and the influence of epigenetic mechanisms involved in the regulation of gene expression responsible for the hyperproduction of immunoglobulin E are discussed. The characteristics of the microbiota of infants with already developed atopic diseases and children at risk of atopy are analyzed. In infants who subsequently developed atopy, the composition of gut microbiota at the birth is characterized by a reduced abundance of bifidobacteriaΒ and high content of potentially pathogenic microorganisms.Β The triggering role of active metabolites of altered microbiota on the differentiation of T-regulatoryΒ cells has been established.Β A preventive effect of optimal breastfeeding has been confirmed: meta-analyzes of recent studies indicate a link between the duration of breastfeedingΒ and a decrease in the frequency of bronchial asthma. The microbiota of breast milk contributes to the proper development of the infantβs microbiota, determines its diversity and immunomodulating action. On the basis of the conducted research, methods of targeted correction of the intestinal microbiota in children with risk of atopy can be developed