How Do Socio-Demographic Characteristics Affect Users’ Perception of Place Quality at Station Areas? Evidence from Amsterdam, The Netherlands

Incorporating users’ experiences in transport hub (re)development has become paramount, especially in the case of (high-speed) railway stations located in central urban locations. Designing “quality” according to users’ perspectives requires that we rethink about the dimensions to be prioritized, but also consider the variegated perspectives of users. Drawing on data from a survey of 452 users of the Amsterdam Central station area in the Netherlands, the relative importance of three value perspectives (node, place, and experience) on place quality were assessed through exploratory factor analysis. Seven quality factors were identified. Furthermore, relationships between socio-demographic characteristics and quality perceptions were simultaneously analyzed using a path analysis. The outcome showed that age and gender play a key role in explaining different quality perceptions. Senior citizens attach a higher importance to basic needs and safety and advanced services, while women also find wayfinding important. Moreover, education and visiting purpose influence other aspects of place quality perception, such as shopping or transfer. These findings provide a better understanding of place quality considerations in railway station areas in general and can serve as guidelines for the improvement of Amsterdam Central station, in particular

Collective self-build for senior friendly communities. Studying the effects on social cohesion, social satisfaction and loneliness

Neighbourhood social cohesion is important for the health and well-being of the ageing population. It is therefore crucial to study how we can create neighbourhoods with high levels of neighbourhood social cohesion where senior citizens can age in place. We test the hypotheses that collective self-build is positively related to social cohesion and (directly and indirectly) to social satisfaction and lower levels of loneliness. The study is based on survey data from 326 respondents of 50 years and over living in 25 collective self-build development projects and 19 conventionally developed housing projects in the Netherlands. The results of a structural equation model (SEM) reveal that collective self-build is directly related to neighbourhood social cohesion and lower feelings of social loneliness. We find an indirect effect on social satisfaction. These positive relationships hold while controlling for personal and household characteristics. This quantitative study adds scientific knowledge on the collective self-build development method and its relation to social cohesion, loneliness and satisfaction

Higher hydrocortisone dose increases bilirubin in hypopituitary patients- Results from an RCT

Background Bilirubin has anti-oxidative and anti-inflammatory properties, which may explain its proposed protective effects on the development of cardiometabolic disorders. Glucocorticoids affect heme oxygenase regulation in vitro, which plays a key role in bilirubin production. Effects of variations in glucocorticoid exposure on circulating bilirubin levels in humans are unknown. Here we tested whether a higher hydrocortisone replacement dose affects circulating bilirubin in hypopituitary patients. Materials and methods A randomized double-blind cross-over study (ClinicalTrials.gov, number NCT01546992) was performed in 47 patients with secondary adrenal failure [10-week exposure to a higher hydrocortisone dose (0.4-0.6 mg/kg body weight) vs. 10 weeks of a lower hydrocortisone dose (0.2-0.3 mg/kg body weight)]. Results Plasma total bilirubin was increased by 10% from 7 to 8 mu M in response to the higher hydrocortisone dose (P = 0.033). This effect was inversely related to age (P = 0.042), but was unaffected by sex, obesity and (replacement for) other hormonal insufficiencies. The higher hydrocortisone dose also resulted in lower alkaline phosphatase (P = 0.006) and aspartate aminotransferase activities (P = 0.001). Conclusion Bilirubin is modestly increased in response to higher glucocorticoid exposure in humans, in conjunction with lower alkaline phosphatase and aspartate aminotransferase activities, which are supposed to represent biomarkers of a pro-inflammatory state and enhanced liver fat accumulation