Unadjusted and adjusted odds ratios (95% CI) for recording of FH of CHD, from the multilevel logistic regression model^*.

<p>Results are derived using 2^nd order linearisation and PQL estimation type.</p><p>Adjusted for sex, age category, year of registration and Townsend score.</p

Demographic characteristics of patients in the complete sample.

<p>Percentages are proportions of the total cohort (1,504,535).</p><p>Percentages are proportions of the cohort of patients with any FH recorded (283,715).</p><p>Percentages are proportions of the cohort of patients with positive FH of CHD recorded (140,058).</p><p>Age was missing for 0.96% of the total sample.</p><p>Townsend Score was missing for 6.70% of the total sample.</p

Demographic trends of patients with FH of CHD recorded, by age category and year of registration.

<p>Values are out of the total sample: 1,389,965 (excl missing values). Reports the proportion of patients with any FH of CHD within each subgroup (age group and year of practice registration).</p

Pattern of FH quality by year of registration, Townsend score and age category (excluding missing values).

<p>Pattern of FH quality by year of registration, Townsend score and age category (excluding missing values).</p

Additional file 1 of Sample size requirements are not being considered in studies developing prediction models for binary outcomes: a systematic review

Supplementary Material

Reporting guidelines used varying methodology to develop recommendations

Background and objectives: We investigated the developing methods of reporting guidelines in the EQUATOR (Enhancing the QUAlity and Transparency Of health Research) Network's database. Methods: In October 2018, we screened all records and excluded those not describing reporting guidelines from further investigation. Twelve researchers performed duplicate data extraction on bibliometrics, scope, development methods, presentation, and dissemination of all publications. Descriptive statistics were used to summarize the findings. Results: Of the 405 screened records, 262 described a reporting guidelines development. The number of reporting guidelines increased over the past 3 decades, from 5 in the 1990s and 63 in the 2000s to 157 in the 2010s. Development groups included 2-151 people. Literature appraisal was performed during the development of 56% of the reporting guidelines; 33% used surveys to gather external opinion on items to report; and 42% piloted or sought external feedback on their recommendations. Examples of good reporting for all reporting items were presented in 30% of the reporting guidelines. Eighteen percent of the reviewed publications included some level of spin. Conclusion: Reporting guidelines have been developed with varying methodology. Reporting guideline developers should use existing guidance and take an evidence-based approach, rather than base their recommendations on expert opinion of limited groups of individuals.</p