CB1 expression in the Fallopian tube.

<p>CB1 mRNA expression was lower in the follicular compared to the luteal phase. In Fallopian tube from women with ectopic pregnancy, CB1 mRNA expression was also low (p<0.05).</p

Immunohistochemistry for CB1 protein expression in Fallopian tube.

<p>CB1 protein was expressed in the smooth muscle of the wall (A and B), the smooth muscle of the endothelial vessels (A and C) and in the cytoplasm of the luminal epithelium of the Fallopian tube (A, B and D). There was no evidence of nuclear or stromal expression. EPI = epithelium, STR = stroma, SM = smooth muscle, BV = blood vessel. Scale bar = 50 microns.</p

Demographics for Fallopian tube and endometrial biopsies from women undergoing surgery for benign gynecological conditions.

<p>TAH = total abdominal hysterectomy.</p><p>STAH = sub-total hysterectomy.</p><p>LAVH = laparoscopically-assisted vaginal hysterectomy.</p><p>HMB = heavy menstrual bleeding.</p

Allelic frequencies of rs1049353 (1359G/A) and rs806368 (3′UTR) single nucleotide polymorphisms (SNPs) of the <i>CNR1</i> gene in women with ectopic and intra-uterine (surgical termination of pregnancies and miscarriage groups combined) pregnancies.

<p>While rs1049353 GG homozygotes constituted 55 versus 29% of ectopic and intra-uterine cohorts, respectively, differences in genotype distributions were not statistically significant (Likelihood Ratio and Pearson analyses had p = 0.18 and 0.15, respectively). The rs806368 SNP was not informative as all ectopic and 13/14 intra-uterine subject DNAs were TT homozygotes.</p

Genomic organization of <i>CNR1</i> gene and SNPs.

<p>The <i>CNR1</i> gene is a single exon gene located on chromosome 6q14–15 that is represented by a rectangle box (the orientation of the transcription of the gene is indicated by the arrow). The SNPs genotyped are represented by the vertical lines and their position in base pairs according to their chromosomal location. The names of the <i>CNR1</i> SNPs according to the NCBI database are indicated by the prefix ‘rs’.</p