Taal en veiligheid: een groeiend nieuw werkveld [Language and security: a growing new field of work]

Language issues cause safety problems at work. This study presents an inventory of scientific studies in the economic sectors and assesses which level of risk management they address. Complications with language have not been investigated comprehensively across sectors as a causal factor in accidents. This leaves language related risks partially unknown, hence uncontrolled. There is lack of insight in both the nature and magnitude of this danger in healthcare, agricultural, transport and construction sectors. Healthcare is especially troublesome since patients might be victims of language related accidents due to their presence and interaction. The same may occur to members of the public in traffic accidents. In transport and agricultural sectors safety measures were taken without any analysis of language related risks. This study shows that scientific research on ‘language and safety’ is in its infancy and requires priority on the research agenda

Conclusion

 If you search for ´transparency´ on an internet search engine, it will provide more than 87 million hits to choose from. By clicking through the results, a diverse variety of types of transparency can be found, ranging from governmental or state transparency to transparency in the financial sector to transparency in sports. While some hits provide state or corporate policies on transparency, others refer to organizations that push for increased openness of organizations. Transparency is a concept that can be applied to a broad variety of different situations and domains in our social, political and economic world, often making it difficult to grasp clearly defined conditions. Since transparency seemingly illustrates a concept with unparalleled possibilities of application, it was referred to as a ´buzzword´ throughout this volume. The contributions of this volume sought, however, to give more substance to the ‘buzzword’. In which fields of social life do matters of transparency come up? What specific role does it play? Do we understand it in an instrumental or consequential way? Who or what is at the focal point of transparency – individuals, public persons, institutions or professions? The answers to these questions, which seek to define the characteristics and criteria of transparency, and the expectations attached to the concept will differ from case to case. What is needed, therefore, is further refinement of what is actually meant when speaking about transparency. Such refinement is inevitably context-based. This is exactly what this volume aimed to do: it analyzes the concept of transparency within specific cases and attempts to show what implications it can have for individuals, politics, social media, international development aid and the pharmaceutical industry. In this regard, the approaches of our authors followed the rationale that transparency is not to be understood as a value in itself, but as instrumental in achieving specific objectives

Transparency – more than a buzzword?

The concept of transparency can be applied to nearly every domain of human activity. In each of these diverse domains transparency is thought to provide the public with information in order to make reasoned judgements: be it information about who to vote for, who to employ, which medications to take, or which Non Governmental Organization to support. If people are sufficiently informed, the argument goes, they are able to hold political officials accountable, find more competent staff, and even punish mismanagement and corruption. As Bessire (2005) puts it, “transparency is strongly related to information – and information is power” (p. 429). This line of reasoning ignores the fact that the availability of information is not the only aspect of accountability. If the public does not know what is happening behind closed doors, it naturally has no incentive – and indeed no chance – to hold somebody accountable necessary. As well as having access to relevant information, people must have measures at their disposal to punish responsible actors

Adaptive compliant structures for flow regulation

<p>(<b>A</b>) Hour of the day when the urine sample was taken. 0 = midnight. (<b>B</b>) Fluid retention index depending on the time of day when urine sample was taken. (<b>C</b>) Period of time during which volunteers abstained from fluid intake before voiding. (<b>D</b>) Fluid retention index depending on the time period without fluid intake.</p

Epigenetic profiles in children with a neural tube defect; a case-control study in two populations

Folate deficiency is implicated in the causation of neural tube defects (NTDs). The preventive effect of periconceptional folic acid supplement use is partially explained by the treatment of a deranged folate-dependent one carbon metabolism, which provides methyl groups for DNA-methylation as an epigenetic mechanism. Here, we hypothesize that variations in DNA-methylation of genes implicated in the development of NTDs and embryonic growth are part of the underlying mechanism. In 48 children with a neural tube defect and 62 controls from a Dutch case-control study and 34 children with a neural tube defect and 78 controls from a Texan case-control study, we measured the DNA-methylation levels of imprinted candidate genes (IGF2-DMR, H19, KCNQ1OT1) and non-imprinted genes (the LEKR/CCNL gene region associated with birth weight, and MTHFR and VANGL1 associated with NTD). We used the MassARRAY EpiTYPER assay from Sequenom for the assessment of DNA-methylation. Linear mixed model analysis was used to estimate associations between DNA-methylation levels of the genes and a neural tube defect. In the Dutch study group, but not in the Texan study group we found a significant association between the risk of having an NTD and DNA methylation levels of MTHFR (absolute decrease in methylation of -0.33% in cases, P-value = 0.001), and LEKR/CCNL (absolute increase in methylation: 1.36% in cases, P-value = 0.048), and a borderline significant association for VANGL (absolute increase in methylation: 0.17% in cases, P-value = 0.063). Only the association between MTHFR and NTD-risk remained significant after multiple testing correction. The associations in the Dutch study were not replicated in the Texan study. We conclude that the associations between NTDs and the methylation of the MTHFR gene, and maybe VANGL and LEKKR/CNNL, are in line with previous studies showing polymorphisms in the same genes in association with NTDs and embryonic development, respectively

Adaptive compliant structures for flow regulation

This paper introduces conceptual design principles for a novel class of adaptive structures that provide both flow regulation and control. While of general applicability, these design principles, which revolve around the idea of using the instabilities and elastically nonlinear behaviour of post-buckled panels, are exemplified through a case study: the design of a shape-adaptive air inlet. The inlet comprises a deformable post-buckled member that changes shape depending on the pressure field applied by the surrounding fluid, thereby regulating the inlet aperture. By tailoring the stress field in the post-buckled state and the geometry of the initial, stress-free configuration, the deformable section can snap through to close or open the inlet completely. Owing to its inherent ability to change shape in response to external stimuli—i.e. the aerodynamic loads imposed by different operating conditions—the inlet does not have to rely on linkages and mechanisms for actuation, unlike conventional flow-controlling devices.</jats:p