Legislative Documents

Also, variously referred to as: House bills; House documents; House legislative documents; legislative documents; General Court documents

Legislative Documents

Also, variously referred to as: House bills; House documents; House legislative documents; legislative documents; General Court documents

Image_3_Dynamics of Pellet Fragmentation and Aggregation in Liquid-Grown Cultures of Streptomyces lividans.TIF

<p>Streptomycetes are extensively used for the production of valuable products, including various antibiotics and industrial enzymes. The preferred way to grow these bacteria in industrial settings is in large-scale fermenters. Growth of streptomycetes under these conditions is characterized by the formation of complex mycelial particles, called pellets. While the process of pellet formation is well characterized, little is known about their disintegration. Here, we use a qualitative and quantitative approach to show that pellet fragmentation in Streptomyces lividans is initiated when cultures enter the stationary phase, which coincides with a remarkable change in pellet architecture. Unlike young pellets, aging pellets have a less dense appearance and are characterized by the appearance of filaments protruding from their outer edges. These morphological changes are accompanied by a dramatic increase in the number of mycelial fragments in the culture broth. In the presence of fresh nutrients, these fragments are able to aggregate with other small fragments, but not with disintegrating pellets, to form new mycelial particles. Altogether, our work indicates that fragmentation might represent an escape mechanism from the environmental stress caused by nutrient scarcity, with striking similarities to the disassembly of bacterial biofilms.</p

Effect of pregnancy at mid gestation on in vivo and whole organ perfusion# renal vascular resistance (RVR), renal flow and glomerular filtration rate (GFR) in absence and presence of NO and sympathetic blockade.

<p>The effect of pregnancy on RVR, renal flow (effects of renal plasma/blood/perfusion flow (RPF/RBF/RPPF) combined) and GFR is presented as percentage mean difference (MD) and its 95% CI. Studies and totals based on Long Evans rats (LER), Munich Wistar rats (MWR), Sprague Dawley rats (SDR) and Wistar Hannover rats (WHR). 1, 2, 3 represents first, second and third part of mid gestation. # Whole organ perfusion experiments, excluded in the “Overall in vivo“ analysis. * Experiments performed under anesthesia. I² represents the amount of heterogeneity. n.a.  =  not applicable.</p

Literature search-strategy for Embase.

<p>Literature search-strategy for Embase.</p

Quality assessment of the included studies and subsequent responses.

<p>(1) randomization, (2) blinding of outcome assessor, (3) virgin/nulliparous at entry study, (4) age or weight of animals described, (5) number of used animals clear from methods, (6) fraction of responses with clear number of animals used for statistical analyses (as a percentage of the number of described responses), (7) fraction of responses with dose-response curve containing ≥5 measurements, (8) fraction of responses with accomplished E_max. n.a.  =  not applicable.</p>#<p>data received by email.</p><p>Quality assessment of the included studies and subsequent responses.</p

Effect of pregnancy at late gestation on in vivo renal vascular resistance (RVR), renal flow and glomerular filtration rate (GFR) in absence of blockade.

<p>The effect of pregnancy on RVR, renal flow (effects of renal plasma/blood/perfusion flow (RPF/RBF/RPPF) combined) and GFR is presented as percentage mean difference (MD) and its 95% CI. Studies and totals based on Long Evans rats (LER), Munich Wistar rats (MWR), Sprague Dawley rats (SDR), rabbits and sheep. 1, 2, 3 represents first, second and third part of late gestation. * Experiments performed under anesthesia. I² represents the amount of heterogeneity. n.a.  =  not applicable.</p

Summary of renal vascular resistance (RVR), renal flow and glomerular filtration rate (GFR) during pregnancy in Long Evens rats (LER), Munich Wistar rats (MWR) and Sprague Dawley rats (SDR).

<p>Graph design based on data at mid- and late gestation. No data were available on early pregnancy.</p

Effect of pregnancy at mid and late gestation on renal artery responses to stimuli involved in vasoconstriction through the GqSMC-coupled pathway in presence and absence of blockade.

<p>The effect of pregnancy on EC₅₀ (the dose of stimulus inducing 50% response) is depicted as mean difference (MD) and its 95% confidence interval (95% CI). E_max (maximum response) is presented as standardized mean difference (SMD) and its 95% CI. Studies and totals based on Long Evans rats (LER), Sprague Dawley rats (SDR), sheep and guinea pigs (GP). 1, 2, 3 represents first, second and third part of mid and late gestation. I² represents the amount of heterogeneity. n.a.  =  not applicable.</p

Effect of mid and late pregnancy on renal artery responses to nitric oxide (NO) and potassium.

<p>The effect of pregnancy on EC₅₀ (the dose of stimulus inducing 50% response) is depicted as mean difference (MD) and its 95% confidence interval (95% CI). E_max (maximum response) is presented as standardized mean difference (SMD) and its 95% CI. Studies and totals based on Long Evans rats (LER), Sprague Dawley rats (SDR) and sheep. 1, 2, 3 represents first, second and third part of mid and late gestation. I² represents the amount of heterogeneity. n.a.  =  not applicable.</p