Bacterial strains used in this study.

*<p>VET-study, isolates collected for a longitudinal MRSA carriage study among veterinarians and written consent was provided by all participants (E. Verkade personal communication).</p

Additional file 1: of Exposure to common respiratory bacteria alters the airway epithelial response to subsequent viral infection

Supplemental information. (ZIP 83 kb

Detail of whole genome maps showing differences between HA-MRSA outbreak isolates obtained from a large medical care center in the Netherlands.

<p>Based on molecular typing (<i>spa</i>-typing, MLVA and PFGE) all isolates were indistinguishable.</p

Detail of the whole genome maps of an outbreak of CA-MRSA (USA300) showing an additional DNA segment in 3 isolates.

<p>All isolates had <i>spa</i>-type t024 and MLVA-type MT308. The gel image on the right hand side shows the PFGE profiles with an additional 80 kb band in the lower 3 isolates.</p

Complete WGMs of LA-MRSA isolates obtained from a confirmed transmission event.

<p>The 4 isolates represent 3 household members and 1 isolate originated from a pig on the farm. All isolates were identical in PFGE, <i>spa</i>-typing and MLVA.</p

Detail of the WGMs of 16 LA-MRSA isolates originating from unrelated veterinarians showing the discriminatory power of whole genome mapping.

<p>The limited variation obtained by MLVA- and <i>spa</i>-typing is displayed on the right hand side of the WGMs. The blowup of the WGMs displays considerable variation in the SCC<i>mec</i> region.</p

Examples of differences between the WGMs created in the lab and their <i>in-silico</i> counterparts.

<p>The figure shows details of the comparisons of the maps of LA-MRSA strain S0385 and MRSA strains N315 and NCTC8325. The WGMs are represented as linear maps displaying the fragments in randomly chosen colours, with matching fragments sharing the same colour.</p

Detail of the WGMs of two veterinarians and their household members showing transmission events.

<p>A and B denote the clusters with highly similar WGMs of isolates obtained from VET45 and his household members (light red block). C denotes the cluster with highly similar WGMs of isolates obtained from VET66 and his household members (blue block). Sampling time-points, sampling sites, <i>spa</i>-type, MLVA-type and PFGE-type are indicated on the right hand side of the maps. The PFGE-type numbers are arbitrary numbers.</p

Additional file 2: of Social networks in relation to self-reported symptomatic infections in individuals aged 40–75 - the Maastricht study –

Table 1. Associations between characteristics of the participants and self reported upper- and lower respiratory, gastrointestinal, and urinary tract infections in The Maastricht Study (n = 3004). The associations of demographic characteristics (sex, age, type 2 diabetes, body mass index, season, educational level, smoking status, alcohol consumption, and employment status) with URI, LRI, GI and UTI were shown. (DOCX 21 kb

Additional file 1: of Social networks in relation to self-reported symptomatic infections in individuals aged 40–75 - the Maastricht study –

Statistical formula for the derivation of the Index of Qualitative Variation. Statistical formula for the derivation of the Index of Qualitative Variation, with an example how to compute the IQV. (DOCX 19 kb