High Density Molecular Gas in the IR-bright Galaxy System VV114

New high resolution CO(3-2) interferometric map of the IR-bright interacting galaxy system VV114 observed with the Submillimeter Array (SMA) reveal a substantial amount of warm and dense gas in the IR-bright but optically obscured galaxy, VV114E, and the overlap region connecting the two nuclei. A 1.8 x 1.4 kpc concentration of CO(3-2) emitting gas with a total mass of 4 x 10^9 Msun coincides with the peaks of NIR, MIR, and radio continuum emission found previously by others, identifying the dense fuel for the AGN and/or the starburst activity there. Extensive CO(2-1) emission is also detected, revealing detailed distribution and kinematics that are consistent with the earlier CO(1-0) results. The widely distributed molecular gas traced in CO(2-1) and the distributed discrete peaks of CO(3-2) emission suggest that a spatially extended intense starbursts may contribute significantly to its large IR luminosity. These new observations further support the notion that VV114 is approaching its final stage of merger, when violent central inflow of gas triggers intense starburst activity possibly boosting the IR luminosity above the ultraluminous threshold.Comment: 11 pages, 2 figures, accepted for publication in ApJ

The Dynamics of Molecular Material Within 15 pcs of the Galactic Center

We report the results of a 5-field mosaic of the central 15pc of the Galaxy in the (1,1) and (2,2) lines of NH3. Two narrow filaments or streamers are seen running parallel to the Galactic plane. The southern streamer appears to carry gas directly toward the nuclear region from the 20 km/s cloud. The eastern streamer, which we will denote the molecular ridge, appears to be the denser part of the 50 km/s cloud which lies immediately east of the Sgr A East complex and extends in the south towards the 20 km/s cloud. This ridge of gas carries the kinematical signatures of interactions with Sgr A East as well as a SNR which lies south of the Galactic center. The bulk motion of the gas, the enhanced line widths, and the heating of the molecular material all suggest an active evolutionary phase for the gas immediately adjacent to the nucleus.Comment: 11 pages, 13 figures, to appear in The Astrophysical Journa

Analysis of state laws on informed consent for clinical genetic testing in the era of genomic sequencing

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/143694/1/ajmgc31608_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/143694/2/ajmgc31608.pd

Kinematics of the Broad-line Region of 3C 273 from a Ten-year Reverberation Mapping Campaign

Despite many decades of study, the kinematics of the broad-line region of 3C~273 are still poorly understood. We report a new, high signal-to-noise, reverberation mapping campaign carried out from November 2008 to March 2018 that allows the determination of time lags between emission lines and the variable continuum with high precision. The time lag of variations in H$\beta$ relative to those of the 5100 Angstrom continuum is $146.8_{-12.1}^{+8.3}$ days in the rest frame, which agrees very well with the Paschen-$\alpha$ region measured by the GRAVITY at The Very Large Telescope Interferometer. The time lag of the H$\gamma$ emission line is found to be nearly the same as for H$\beta$. The lag of the Fe II emission is $322.0_{-57.9}^{+55.5}$ days, longer by a factor of $\sim$2 than that of the Balmer lines. The velocity-resolved lag measurements of the H$\beta$ line show a complex structure which can be possibly explained by a rotation-dominated disk with some inflowing radial velocity in the H$\beta$-emitting region. Taking the virial factor of $f_{\rm BLR} = 1.3$, we derive a BH mass of $M_{\bullet} = 4.1_{-0.4}^{+0.3} \times 10^8 M_{\odot}$ and an accretion rate of $9.3\,L_{\rm Edd}\,c^{-2}$ from the H$\beta$ line. The decomposition of its $HST$ images yields a host stellar mass of $M_* = 10^{11.3 \pm 0.7} M_\odot$, and a ratio of $M_{\bullet}/M_*\approx 2.0\times 10^{-3}$ in agreement with the Magorrian relation. In the near future, it is expected to compare the geometrically-thick BLR discovered by the GRAVITY in 3C 273 with its spatially-resolved torus in order to understand the potential connection between the BLR and the torus.Comment: 17 pages, 12 figures, 6 tables, accepted for publication in The Astrophysical Journa

Effects of various sugars added to growth and drying media upon thermotolerance and survival throughout storage of freeze-dried lactobacillus delbrueckii ssp. bulgaricus

The aim of this research effort was to investigate the role of various sugar substrates in the growth medium upon thermotolerance and upon survival during storage after freeze-drying of Lactobacillus bulgaricus. Addition of the sugars tested to the growth medium, and of these and sorbitol to the drying medium (skim milk) was investigated so as to determine whether a relationship exists between growth and drying media, in terms of protection of freeze-dried cells throughout storage. The lowest decrease in viability of L. bulgaricus cells after freeze-drying was obtained when that organism was grown in the presence of mannose. However, L. bulgaricus clearly survived better during storage when cells had been grown in the presence of fructose, lactose or mannose rather than glucose (the standard sugar in the growth medium). A similar effect could not be observed in terms of thermotolerance; in this case, the growth medium supplemented with lactose was found to yield cells bearing the highest heat resistance. Supplementation of the drying medium with glucose, fructose, lactose, mannose or sorbitol led in most cases to enhancement of protection during storage, to a degree that was growth medium-dependent

Relevant factors for the preparation of freeze-dried lactic acid

The industrial exploitation of lactic acid bacteria (LAB) as starter and/or probiotic cultures depends strongly on the preservation technologies employed, which are required to guarantee long-term delivery of stable cultures in terms of viability and activity. Freeze-dried preparations exhibit advantages relative to preparations made with other techniques in terms of long-term preservation, coupled with convenience in handling, storage, marketing and application. Degrees of survival of LAB cultures as high as possible, during drying and subsequent storage, are thus of nuclear importance, both technologically and economically. This review covers several factors, deemed relevant for preservation of freeze-dried LAB. The state of the art of the knowledge focussed on the improvement of LAB survival during freeze-drying and subsequent storage is presented, including specific discussion of the effects of (i) intrinsic factors, (ii) growth factors, (iii) sub-lethal treatments, (iv) drying media and (v) storage and rehydration