Party Competition in Illinois: Republican Prospects in a Blue State

Campaigns and elections in Illinois are always interesting and exciting spectacles. They are full of colorful characters, great plots, and unexpected twists to the story line. Each election brings new characters and different stories, but each builds on the rich tradition and culture of a big and diverse state which takes its politics and politicians quite seriously. A state which over the last half century has produced such notables as Everett Dirksen, Paul Douglas, Adlai Stevenson, Jr., Charles Percy, Paul Simon, Alan Dixon, Richard Ogilvie, Dan Walker, Dan Rostenkowski, Richard J. Daley, Harold Washington, Richard M. Daley, Russell Arrington, Phil Rock, Michael Madigan, Pate Phillip, Roland Burris, George Ryan, Jim Edgar, Jim Thompson, Richard Durbin, Barack Obama, Emil Jones, Judy Barr Topinka, and Rod Blagojevich clearly has a great political culture and a compelling political history. We have had our scoundrels and some have ended up in federal prison. We have had our statesmen of the past and some of our present leaders hold national office with great prominence and prospects for national leadership

Single channel properties of a volume sensitive anion channel: Lessons from noise analysis

Single channel properties of a volume sensitive anion channel: Lessons from noise analysis. Swelling activated anion channels have recently been recognized to play an important role in not only volume regulatory electrolyte movement, but also in organic osmolyte transport. A swelling-activated, outwardly rectifying anion channel termed VSOAC (volume-sensitive organic osmolyte/anion channel) is a major pathway for swelling-induced loss of organic osmolytes and organic anions from mammalian cells. VSOAC has been described in numerous cell types. Until recently, however, the unitary conductance and gating kinetics of VSOAC were uncertain. Stationary noise analysis and single channel measurements have produced estimates for the unitary conductance of swelling-activated, outwardly rectifying anion channels that vary by > 15-fold. This review describes our current understanding of the single channel properties of VSOAC

Validity of effective material parameters for optical fishnet metamaterials

Although optical metamaterials that show artificial magnetism are mesoscopic systems, they are frequently described in terms of effective material parameters. But due to intrinsic nonlocal (or spatially dispersive) effects it may be anticipated that this approach is usually only a crude approximation and is physically meaningless. In order to study the limitations regarding the assignment of effective material parameters, we present a technique to retrieve the frequency-dependent elements of the effective permittivity and permeability tensors for arbitrary angles of incidence and apply the method exemplarily to the fishnet metamaterial. It turns out that for the fishnet metamaterial, genuine effective material parameters can only be introduced if quite stringent constraints are imposed on the wavelength/unit cell size ratio. Unfortunately they are only met far away from the resonances that induce a magnetic response required for many envisioned applications of such a fishnet metamaterial. Our work clearly indicates that the mesoscopic nature and the related spatial dispersion of contemporary optical metamaterials that show artificial magnetism prohibits the meaningful introduction of conventional effective material parameters

Increased GABA Contributes to Enhanced Control over Motor Excitability in Tourette Syndrome

Tourette syndrome (TS) is a developmental neurological disorder characterized by vocal and motor tics [1] and associated with cortical-striatal-thalamic-cortical circuit dysfunction [2, 3], hyperexcitability within cortical motor areas [4], and altered intracortical inhibition [4, 5, 6, 7]. TS often follows a developmental time course in which tics become increasingly more controlled during adolescence in many individuals [1], who exhibit enhanced control over their volitional movements [8, 9, 10, 11]. Importantly, control over motor outputs appears to be brought about by a reduction in the gain of motor excitability [6, 7, 12, 13]. Here we present a neurochemical basis for a localized gain control mechanism. We used ultra-high-field (7 T) magnetic resonance spectroscopy to investigate in vivo concentrations of γ-aminobutyric acid (GABA) within primary and secondary motor areas of individuals with TS. We demonstrate that GABA concentrations within the supplementary motor area (SMA)—a region strongly associated with the genesis of motor tics in TS [14]—are paradoxically elevated in individuals with TS and inversely related to fMRI blood oxygen level-dependent activation. By contrast, GABA concentrations in control sites do not differ from those of a matched control group. Importantly, we also show that GABA concentrations within the SMA are inversely correlated with cortical excitability in primary motor cortex and are predicted by motor tic severity and white-matter microstructure (FA) within a region of the corpus callosum that projects to the SMA within each hemisphere. Based upon these findings, we propose that extrasynaptic GABA contributes to a form of control, based upon localized tonic inhibition within the SMA, that may lead to the suppression of tics

Gibbs Sampling with Low-Power Spiking Digital Neurons

Restricted Boltzmann Machines and Deep Belief Networks have been successfully used in a wide variety of applications including image classification and speech recognition. Inference and learning in these algorithms uses a Markov Chain Monte Carlo procedure called Gibbs sampling. A sigmoidal function forms the kernel of this sampler which can be realized from the firing statistics of noisy integrate-and-fire neurons on a neuromorphic VLSI substrate. This paper demonstrates such an implementation on an array of digital spiking neurons with stochastic leak and threshold properties for inference tasks and presents some key performance metrics for such a hardware-based sampler in both the generative and discriminative contexts.Comment: Accepted at ISCAS 201

First-principles calculations of magnetization relaxation in pure Fe, Co, and Ni with frozen thermal lattice disorder

The effect of the electron-phonon interaction on magnetization relaxation is studied within the framework of first-principles scattering theory for Fe, Co, and Ni by displacing atoms in the scattering region randomly with a thermal distribution. This "frozen thermal lattice disorder" approach reproduces the non-monotonic damping behaviour observed in ferromagnetic resonance measurements and yields reasonable quantitative agreement between calculated and experimental values. It can be readily applied to alloys and easily extended by determining the atomic displacements from ab initio phonon spectra

Mass and dust in the disk of a spiral lens galaxy

Gravitational lensing is a potentially important probe of spiral galaxy structure, but only a few cases of lensing by spiral galaxies are known. We present Hubble Space Telescope and Magellan observations of the two-image quasar PMN J2004-1349, revealing that the lens galaxy is a spiral galaxy. One of the quasar images passes through a spiral arm of the galaxy and suffers 3 magnitudes of V-band extinction. Using simple lens models, we show that the mass quadrupole is well-aligned with the observed galaxy disk. A more detailed model with components representing the bulge and disk gives a bulge-to-disk mass ratio of 0.16 +/- 0.05. The addition of a spherical dark halo, tailored to produce an overall flat rotation curve, does not change this conclusion.Comment: ApJ, in press [9pp, 7 figs