Phylogenetic Relationship of PF07598 Paralogous Family in <i>Leptospira</i>.

<p>(A) Unrooted bootstrapped phylogenetic tree; (*) Gene duplication event; (**) gene duplication event; (***) gene deletion. (B) Principal components analysis was used to arrange PF07598 family members. Color legend indicates the PF07598 family members from specific serovars depicted as diamonds. Arrowheads indicate <i>L</i>. <i>noguchii</i>-specific orthologs. Only PF07598 family members longer than 200 amino acids are included in the analysis. Clusters (A, B and C) were defined by K-means clustering with Kendall rank correlation.</p

Leptospiral species metadata and genome statistics.

<p>Leptospiral species metadata and genome statistics.</p

TAT signal sequence in <i>Leptospira sp</i>.

<p>The X-axis shows position in an ungapped alignment. The Y-axis shows information content, measured in bits.</p

Phylogenetic analysis of <i>Leptospira</i> species.

<p>Consensus maximum-likelihood trees are depicted using multiple alignments of 16S rRNA (A), secY (B), MLST (C) and 39 concatenated protein data sets (D). The numbers along the branches denote percent occurrence of nodes among 100 bootstrap replicates. A pan-genome tree was generated based on the mean of the BLASTP score ratio of core 1135 proteins (E). The scale bar represents the number of nucleotide (A-C), amino acid (D & E) substitutions.</p

Proteins involved in biosynthesis of vitamin B12 in <i>Leptospira</i>.

<p>Proteins involved in biosynthesis of vitamin B12 in <i>Leptospira</i>.</p

CRISPR Spacer Sequences that Recognize <i>Leptospira</i> Predicted Prophages.

<p>The CRISPR sequences are shown, which correspond to specific prophage accession numbers as listed in <a href="http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0004403#pntd.0004403.t004" target="_blank">Table 4</a>.</p

Summary of two component systems identified in 20 <i>Leptospira</i> genomes.

<p>Summary of two component systems identified in 20 <i>Leptospira</i> genomes.</p

Structure of <i>Leptospira rfb locus</i> gene clusters.

<p>The <i>rfb</i> region and beginning and ending CDSs (blue) 9 of pathogenic (A), 5 intermediate (B), and 6 saprophytic (C) representative <i>Leptospira</i> species were compared. <i>rfb</i> region CDSs are labeled by locus identifier and colored by functional role categories as noted in the boxed key. Gene symbols, when present, are noted above their respective genes. BLASTP matches between CDSs are colored by protein percent identity (see key).</p

CRISPR/Cas Systems Identified in <i>Leptospira</i> Species Representatives.

<p>CRISPR/Cas Systems Identified in <i>Leptospira</i> Species Representatives.</p

Leptospiral Proteins for Sialic Acid Biosynthesis.

<p>Leptospiral Proteins for Sialic Acid Biosynthesis.</p