A Multidimensional Relativistic Hydrodynamics Code with a General Equation of State

The ideal gas equation of state with a constant adiabatic index, although commonly used in relativistic hydrodynamics, is a poor approximation for most relativistic astrophysical flows. Here we propose a new general equation of state for a multi-component relativistic gas which is consistent with the Synge equation of state for a relativistic perfect gas and is suitable for numerical (special) relativistic hydrodynamics. We also present a multidimensional relativistic hydrodynamics code incorporating the proposed general equation of state, based on the HLL scheme, which does not make use of a full characteristic decomposition of the relativistic hydrodynamic equations. The accuracy and robustness of this code is demonstrated in multidimensional calculations through several highly relativistic test problems taking into account nonvanishing tangential velocities. Results from three-dimensional simulations of relativistic jets show that the morphology and dynamics of the relativistic jets are significantly influenced by the different equation of state and by different compositions of relativistic perfect gases. Our new numerical code, combined with our proposed equation of state is very efficient and robust, and unlike previous codes, it gives very accurate results for thermodynamic variables in relativistic astrophysical flows.Comment: 32 pages, 9 figures, accepted by ApJ

Rayleigh scattering, mode coupling, and optical loss in silicon microdisks

High refractive index contrast optical microdisk resonators fabricated from silicon-on-insulator wafers are studied using an external silica fiber taper waveguide as a wafer-scale optical probe. Measurements performed in the 1500 nm wavelength band show that these silicon microdisks can support whispering-gallery modes with quality factors as high as 5.2 x 10^5, limited by Rayleigh scattering from fabrication induced surface roughness. Microdisks with radii as small as 2.5 microns are studied, with measured quality factors as high as 4.7 x 10^5 for an optical mode volume of 5.3 cubic wavelengths in the material.Comment: 4 pages, 2 figures; contains minor correction to doublet splitting theor

The Current Understanding of MicroRNA\u27s Therapeutic, Diagnostic, and Prognostic Role in Chordomas: A Review of the Literature.

Chordomas are primary low-grade bone tumors derived from the embryonic notochord that make up less than 5% of all osseous malignancies and commonly affect the spine at its vertebral body and at its two ends i.e., skull base and the sacrum. Although histologically defined to be low-grade, chordoma is locally destructive, metastatic, and has a serious recurrence rate, which all contribute to the dismal median survival rate of six years. Its locally destructive nature places the adjacent vital neurovascular structures at risk, making an en-bloc resection a challenge. This tumor is also known to show high resistance to currently available chemoradiotherapy, although the benefit of proton beam therapy for skull base chordoma has been demonstrated. There is an additional need to focus our attention on investigating the molecular biology of this chemoradiotherapy-resistant tumor to develop a more targeted therapy, which has additional diagnostic and prognostic values. In this paper, we discuss the therapeutic, diagnostic, and prognostic role of microRNAs (miRNAs) in chordomas

Emerging Cellular Therapies for Glioblastoma Multiforme.

Glioblastoma multiforme (GBM) is the most common type of malignant primary brain cancer in adults. It is composed of highly malignant cells that display metastatic and angiogenic characteristics, making it resistant to current first-line chemotherapy with temozolomide, an alkylating agent. Despite many years of research, GBM remains poorly responsive to multiple available therapies, giving GBM patients, who receive the conventional combination of chemoradiotherapies and surgical resection, a dismal prognosis. There is growing evidence that the conventional systemic chemotherapeutic agents for GBM are ineffective in improving the disease progression. We aim to explore the emerging cellular therapies which may play a significant role in treating GBM

The Current Trend of the Translational Research Paradigm.

The translational research paradigm is a process of discovering basic science concepts and applying the knowledge in clinical practice, aiming to improve patient care. The stages involved in the paradigm form a complex network of shared knowledge amongst research collaborators, including patients. This nature of the paradigm allows those involved to work together effectively. However, the translational research paradigm is often overlooked by many scientists, educators, and research institutions. Hence, a large amount of comprehensive and hugely invested research projects fail to make a scientific impact. We aim to outline and describe this paradigm in order to aid in the successful translation of effective research

A Stochastic Single-Molecule Event Triggers Phenotype Switching of a Bacterial Cell

By monitoring fluorescently labeled lactose permease with single-molecule sensitivity, we investigated the molecular mechanism of how an Escherichia coli cell with the lac operon switches from one phenotype to another. At intermediate inducer concentrations, a population of genetically identical cells exhibits two phenotypes: induced cells with highly fluorescent membranes and uninduced cells with a small number of membrane-bound permeases. We found that this basal-level expression results from partial dissociation of the tetrameric lactose repressor from one of its operators on looped DNA. In contrast, infrequent events of complete dissociation of the repressor from DNA result in large bursts of permease expression that trigger induction of the lac operon. Hence, a stochastic single-molecule event determines a cell's phenotype