Cox proportional hazard models and AUC-ROC.

<p>Table displays univariable analyses of risk factors for vascular disease for different endpoints. The bold numbers are accounted in the multivariable model with and without genetic risk scores. AUC-ROC = Area Under Curve of the Receiver Operating Characteristics Curve. M1 = primary outcome. M2 = secondary outcome, ischemic stroke</p><p>Cox proportional hazard models and AUC-ROC.</p

Schematic description of the association model used to quantify the overlap between regulatory elements (black and red DHS peaks) and disease-associated variants (SNP1, 2 and 3) in various cell types (cell type 1, 2 and 3).

<p>The model estimates the regulatory activity by counting the number of DHS peaks (red) located within the region of a 500kb with the associated tag SNP in the middle.</p

ROC curves for the primary outcome.

<p>(a) based on classical risk factors only; (b) based on classical risk factors plus the genetic risk score.</p

Baseline characteristics.

<p>* Patients were excluded because of quality concerns</p><p>Baseline characteristics.</p

Systematic association of common variants identified by 94 different GWAS with open chromatin (DHS) in selected tissues and cells.

<p>The individual GWAS are sorted based on the minimal association p-value with 466 DHS (only selected DHS samples are shown). Size of the dot represents the enrichment over the null distribution and color of the dot represents the significance of the enrichment—with black being the most significant. The bar graphs depict the number of associated SNPs (grey), the fraction of coding SNPs (red) and minor allele frequency (green). Heatmap depicts the distribution of SNPs with respect to transcriptional start sites (intensity of blue depicts the fraction of SNPs within the distance bin). Green/orange/white bar shows the presence of the replication cohort (green—present, white—no replication cohort as specified in the in NHGRI GWAS Catalog) separately for each GWAS. Group bar depicts the annotation of GWAS to one of three “GWAS groups”. Green—GWAS with the best association p-value < = 0.0001, orange < = 0.01 and red—GWAS with the best association p-value < 0.01.</p

Comparison of selected GWAS parameter between three GWAS groups.

<p>A) The number of associated SNPs B) the fraction of coding SNPs C) minor allele frequency and D) the distribution of SNPs with respect to transcriptional start sites (no line—non significant, * p-value < 0.05, ** p-value < 0.01, using Wilcoxon signed-rank test), green—GWAS with the best association p-value < = 0.0001, orange < = 0.01 and red—GWAS with the best association p-value < 0.01.</p

Association between body mass index and plasma log(TG), stratified by rs964184 genotype.

<p>Black line: CC genotype, red line: CG genotype, blue line: GG genotype. Dotted lines indicate 95% confidence interval.</p

Relation between minor allele frequencies and levels of plasma TG.

<p>Rs964184 minor allele frequency (95% confidence interval) at increasing levels of TG. N indicates the number of patients with a plasma TG level in this category.</p