MOESM1 of Repeated salivary daytime cortisol and onset of mood episodes in offspring of bipolar parents

Additional file 1: Table S1. Mean baseline sampling times in high-risk and control offspring. Table S2. Baseline salivary cortisol (nmol/L) in 53 high-risk compared to 22 control offspring. Table S3. Clinical variables predicting baseline cortisol (nmol/L) in high-risk offspring with a DSM-IV mood disorder

Cell lines expression for SYN2b.

<p>Expression in (A) HEK293 embryonic kidney cells, (B) SK-N-AS neuroblastoma cells, and (C) and U-118 MG glioblastoma/astrocytoma cells for the Synapsin IIb variant compared to GAPDH. P-values depicting the mean differences between 3 independent experiments for each cell line at each of the 3 treatment concentration of either lithium or vehicle (0.5 mM, 1.0 mM, and 2.0 mM).</p

Lithium response in lymphoblastoid cell line samples.

<p>ANCOVA analysis was performed to compare the three groups (Controls, Responders, and Non-responders to lithium treatment) separately for Syn2a and Syn2b expression. The variables “Age at sampling” and “LCL frozen storage” were used as covariates.</p

Cell lines expression for SYN2a.

<p>Expression in (A) HEK293 embryonic kidney cells, (B) SK-N-AS neuroblastoma cells, and (C) and U-118 MG glioblastoma/astrocytoma cells for the Synapsin IIa variant compared to GAPDH. P-values depicting the mean differences between 3 independent experiments for each cell line at each of the 3 treatment concentration of either lithium or vehicle (0.5 mM, 1.0 mM, and 2.0 mM).</p

Inter-rater agreement and reliability of the assessment of lithium response in the two-stage case-vignette rating procedure: kappa and intra-class correlation analysis.

<p>TS: total score.</p><p>ICC: intra-class correlation.</p><p>CI: confidence interval.</p>*<p>Mixed and random effects models.</p>§<p>70 raters.</p>¶<p>48 raters.</p

Empirical and theoretical distributions of the total score in the Consortium on Lithium Genetics sample.

<p>Frequentist, <b>A</b>, and Bayesian minimum message length, <b>B</b>, mixture modeling identify three subpopulations of non responders (grey), partial responders (red), and full responders (blue) in total scores of 1,308 bipolar disorder patients characterized for response to lithium maintenance treatment.</p

Distribution of total and A scores in the Consortium on Lithium Genetics sample.

<p>Histogram plot of the scale scores in 1,308 bipolar disorder patients characterized for response to lithium maintenance treatment.</p

Number of raters from the Consortium on Lithium Genetics (ConLiGen) centres participating in the two-stage case-vignette rating procedure for inter-rater reliability and agreement.

<p>ConLiGen: Consortium on Lithium Genetics.</p>*<p>Hokkaido, Osaka, Tokio, Riken Brain Science Institute.</p