12 research outputs found
Elevated Serum Ferritin Is Associated with Reduced Survival in Amyotrophic Lateral Sclerosis
<div><h3>Background</h3><p>Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder caused by the loss of motor neurons. Its etiology remains unknown, but several hypothesis have been raised to explain motor neuron death, including oxidative stress. Dysregulation of cellular iron metabolism can lead to increased oxidative stress, and existing data argue for a role of iron metabolism in ALS pathophysiology.</p> <h3>Methods</h3><p>We performed a retrospective analysis of iron metabolism (IM) variables (serum levels of iron, transferrin, ferritin, and TSC for Transferrin Saturation Coefficient) in a cohort of 694 ALS patients and 297 healthy controls.</p> <h3>Results</h3><p>Serum ferritin levels and TSC were higher, whereas serum transferrin levels were lower in ALS patients than controls. In addition, patients with a high level serum ferritin had a shorter survival time compared to those with low level serum ferritin (618 days versus 921 days for men subgroup; p = .007). Site of onset and ALS-FRS score were not associated with IM variables.</p> <h3>Conclusion</h3><p>This study suggests that ALS patients may have increased iron storage, as measured by increased serum ferritin and TSC. Elevated serum ferritin may also have a deleterious impact on survival in ALS.</p> </div
Additional file 1: of Immune adaptation to chronic intense exercise training: new microarray evidence
Overtraining questionnaire. (PDF 85 kb
ALS-FRS scores in ALS patients according to gender and IM variables tertiles (low, medium and high levels) (means with standard deviations).
<p>For each tertile group, mean age is indicated below ALS-FRS mean value.</p
IM variables levels in ALS patients according to site of onset (means with standard deviations).
<p>p values are adjusted for sex for serum iron, serum transferrin and TSC, and for sex and age for serum ferritin.</p
Serum ferritin levels for women according to age (< or > to 45 years old) and disease status (means with standard deviations).
<p>Serum ferritin levels for women according to age (< or > to 45 years old) and disease status (means with standard deviations).</p
Survival times in ALS patients according to gender and IM variables tertiles (low, medium and high levels) (means with standard deviations, in days).
<p>For each tertile group, mean age is indicated below survival time mean value.</p
General characteristics of healthy controls and ALS populations.
<p>Three slightly different ALS populations are shown here. Among 694 ALS patients with a serum iron value available, serum transferrin values and serum ferritin values were available for 677 and 629 patients, respectively.</p
Additional file 1: of Rapid-Onset Obesity with Hypothalamic Dysfunction, Hypoventilation, and Autonomic Dysregulation (ROHHAD): exome sequencing of trios, monozygotic twins and tumours
Low-coverage proportions of candidate genes in replication exomes. (XLSX 43 kb
CSF spectra by <sup>1</sup>H NMR from ALS patient (A) and non ALS patient (B).
<p>CSF spectra by <sup>1</sup>H NMR from ALS patient (A) and non ALS patient (B).</p
CSF metabolite profiles in ALS and control subjects measured by <sup>1</sup>H NMR spectroscopy.
<p>Data are expressed in median and range. P value inferior to threshold after correction for multiple test (p = 0.003) are shown in bold.</p><p>AHBT: Alphahydroxybutyrate.</p><p>BHBT: Betahydroxybutyrate.</p