Dehydrated Human Calvaria #12–325 NILT Penetration.

<p>Ventral surface of the human skull showing NILT transmission (A) and the limited diffusion pattern observed (B).</p

Dehydrated Rabbit Skull NILT Transmission.

<p>(A) NILT Treatment at Bregma showing the laser spotting light, (B) NILT Penetration and Scatter- Ventral surface of the rabbit skull showing the NILT penetration profile (A) and extensive diffusion pattern observed (B).</p

NILT Penetration Physical Set-up.

<p>Penetration Assembly and NILT Treatment at Bregma for example human calvaria #12–325.</p

Human Skull Characteristics.

<p>Human Skull Characteristics.</p

CT Scan Analysis of Calvaria #12–325.

<p>(A) Radio-opaque skull- Human Calvaria Measurement Point coordinates; (B) Skull Thickness Profiles and (C) Skull Density Profiles. Parametric maps of overall skull thickness and density. Vector positions for measurements are shown in A, Thickness (B) and density (C). Left panels dehydrated calvaria measurement in air; Right panels hydrated degassed measured in air.</p

Correlation analysis: Human Calvaria- Thickness & Density.

<p>Plots of NILT penetration (mW/cm²) vs. thickness (mm) or density (HU). For each of the panels A-D, Pearson correlations are provided. Significant correlation between NILT penetration and thickness (p<0.05), but not density (p>0.05).</p

A) NILT Penetration Across the Skull of 3 Animal Species.

<p>Dehydrated and Hydrated Skull Analysis using a <b><i>Power density of 200–700 mW/cm</i></b>^{<b><i>2</i></b>}- NILT penetration through the skulls of all animal species utilized in this study. Presented as penetration (mW/cm²), calculated based on the area of illumination and the amount of power. In all 3 animals, there was increased NILT penetration through the hydrated (wet) skull compared to the dehydrated (dry) skull (*p<0.05). <b>B) NILT Penetration Across the Skull of 4 Animal Species:</b> Dehydrated and Hydrated Skull Analysis using a <b><i>Power density of 700 mW/cm</i></b>^{<b><i>2</i></b>}- NILT penetration through the skulls of all 4 species utilized in this study. Presented as penetration (mW/cm²), calculated based on the area of illumination and the amount of power. In all 3 animals, there was increased NILT transmission through the hydrated (wet) skull compared to the dehydrated (dry) skull (*p<0.05), but not with human calvaria.</p

Human Calvaria NILT Profiles (Wet Degassed in Air): Surface power density 700 mW/cm².

<p>Measures are provided as Mean ± SEM</p><p>Human Calvaria NILT Profiles (Wet Degassed in Air): Surface power density 700 mW/cm².</p

Animal Skull Transmission: Comparison of Dehydrated- Hydrated State (Surface power density: 700 mW/cm²).

<p>Hydrated state measured in air after degassing. Dehydrated state measured in air. Thickness & Mean Power Applied are provided as Mean ± SEM.</p><p>*Significantly different p<0.05. Mouse dia 2.5mm, Rat/Rabbit dia 11.7mm.</p><p>Animal Skull Transmission: Comparison of Dehydrated- Hydrated State (Surface power density: 700 mW/cm²).</p

Human Calvaria NILT Profiles (Dry State- Air Scan): Surface power density 700 mW/cm².

<p>Measures are provided as Mean ± SEM</p><p>Human Calvaria NILT Profiles (Dry State- Air Scan): Surface power density 700 mW/cm².</p