Precision Medicine in Lung Cancer Treatment

Lung cancer is the leading cause of cancer-related deaths worldwide. Lung cancer remains the second most common cancer in men and women. Traditionally, chemotherapy has been the main Lung cancer is a leading cause of cancer mortality worldwide. The pivotal management for lung cancer progression is for better understanding of the molecular pathogenesis has led to rapid development in the field of targeted therapy and immunotherapy. This has led to significant improvement in survival of patients with lung cancer in initial and later stage carcinogenesis. Lung cancer has been traditionally classified by histology and immune chemistry technology. In tumors, the important role of different medicinal therapy. However, medicinal therapy with individuality gets better response than the tradition approaches. This individual medicine system termed as precision medicine, depends on the nature and prognosis of carcinogenesis in individual system of lung cancer progression. This review focuses on the application of precision medicine in lung cancer treatment and therapy

On a different weighted zero-sum constant

For a finite abelian group $(G,+)$, the constant $C(G)$ is defined to be the smallest natural number $k$, such that any sequence of $k$ elements in $G$ has a subsequence of consecutive terms whose sum is zero. We also define a weighted version of this constant and determine its value for some particular weights, for the group $\mathbb Z_n$.Comment: 15 page

Extremal sequences related to the Jacobi symbol

For a weight-set $A\subseteq \mathbb Z_n$, the $A$-weighted zero-sum constant $C_A(n)$ is defined to be the smallest natural number $k$, such that any sequence of $k$ elements in $\mathbb Z_n$ has an $A$-weighted zero-sum subsequence of consecutive terms. A sequence of length $C_A(n)-1$ in $\mathbb Z_n$ which does not have any $A$-weighted zero-sum subsequence of consecutive terms will be called a $C$-extremal sequence for $A$. Let $\big(\frac{x}{n}\big)$ denote the Jacobi symbol of $x\in\mathbb Z_n$. We characterize the $C$-extremal sequences for the weight-set $S(n)=\big\{\,x\in U(n):\big(\frac{x}{n}\big)=1\,\big\}$ and for the weight-set $L(n;p)=\big\{\,x\in U(n):\big(\frac{x}{n}\big)=\big(\frac{x}{p}\big)\,\big\}$ where $p$ is a prime divisor of $n$. We can define $D$-extremal sequences for these weight-sets in a way analogous to the definition of $C$-extremal sequences. We also characterize these sequences.Comment: 15 pages. arXiv admin note: substantial text overlap with arXiv:2111.1447

Next-generation sequencing: Pyrosequencing and its utilization in medical field

Next-generation sequencing (NGS) can be an idle innovation utilized for DNA and RNA sequencing and variant or mutation study. NGS can arrangement huge qualities or entire genome in a brief period of time. The arrangement variants or mutations recognized by NGS have been broadly utilized for infection. DNA sequencing is one of the foremost critical stages for consideration of organic frameworks nowadays. Arrangement assurance is most commonly performed utilizing deoxy chain end innovation. As of late, pyrosequencing has developed as an unused sequencing methodology. This strategy could be a broadly appropriate, elective innovation for the point by point characterization of nucleic acids. Pyrosequencing has the potential focal points of exactness, adaptability, parallel preparing, and can be effortlessly mechanized. Besides, the strategy apportions with the requirement for abled groundworks, labeled nucleotides, and gel-electrophoresis. This article considers key highlights with respect to distinctive viewpoints of pyrosequencing innovation, counting the common standards, chemical properties, sequencing modes, instrumented, and potential applications. By using these techniques, the DNA sequencing subsequently the precision medicinal field can be explore for the therapeutics approaches for different disease