An Emerging Technique of Medicated Chewing Gum in Drug Delivery System: A Review

Many advances in research and technology have been made in the oral route of drug delivery system in recent years. Because of increased patient compliance not only in geriatric and paediatric patients, but also in the general population, the oral channel of drug delivery system- medicated chewing gum has received worldwide recognition throughout the year. Chewing gum can be used as a mobile medication delivery device for both local and systemic drug administration via the oral route. Because of its ease and ability to be administered without water, it is an exceptional drug delivery device for self-medication. The production technique, advantages, disadvantages, factors impacting the release of medicament, assessment parameter, difficulty related with chewing gum manufacture, and future trends have all been examined in this review pape

A Review on Using an Alcohol-based Sanitizer as A Prophylactic Measure Against Microorganisms

Because of the COVID 19 pandemic, we now utilise hand sanitizer in our daily lives. Hand hygiene has become a legal requirement. Infection control is becoming a requirement. Hand hygiene is widely regarded as the most practical and effective way of infection prevention. Hand sanitizer is thought to have played a significant role in reducing illness transmission to patients. Because it is more cost-effective and efficient. The efficiency of hand sanitizer is totally determined by how it is used. There are two sorts of hand sanitizers on the market. 1) Hand sanitizer with alcohol 2) Hand sanitizer that isn't alcohol-based. Most effective hand sanitizers contain 70 percent to 95 percent alcohol, which has the potential to denature microbial protein and inactivate viruses. The impact of hand sanitizer on human health care is significant, and this review article will provide you with information on several elements of hand sanitize

Review on Medicated Chocolate Takes A Patient-centered Approach to Drug Delivery

The goal is to create medicinally beneficial chocolate that has no negative side effects. Carob (Ceratonia siliqua), a basic ingredient in many chocolate formulations, was substituted for cocoa since it requires a large amount of sugar in the formulation and includes caffeine, which stimulates the CNS. Carob is high in natural sweeteners, has no fat, caffeine, or oxalates, and is high in antioxidants, which assist to prevent a variety of ailments. Many traditional drug delivery systems are ineffective for paediatric patients because their developmental state and dosing requirements differ from those of other groups of people. Age-appropriate medicines require technological platforms to ensure patient acceptability while maintaining safety, efficacy, accessibility, and affordability. Recent methods and accomplishments in the field of age-appropriate drug delivery for paediatric patients are discussed, including patient-centric formulations, administration devices, and packaging solutions

Lung adenocarcinoma promotion by air pollutants

A complete understanding of how exposure to environmental substances promotes cancer formation is lacking. More than 70 years ago, tumorigenesis was proposed to occur in a two-step process: an initiating step that induces mutations in healthy cells, followed by a promoter step that triggers cancer development1. Here we propose that environmental particulate matter measuring ≤2.5 μm (PM2.5), known to be associated with lung cancer risk, promotes lung cancer by acting on cells that harbour pre-existing oncogenic mutations in healthy lung tissue. Focusing on EGFR-driven lung cancer, which is more common in never-smokers or light smokers, we found a significant association between PM2.5 levels and the incidence of lung cancer for 32,957 EGFR-driven lung cancer cases in four within-country cohorts. Functional mouse models revealed that air pollutants cause an influx of macrophages into the lung and release of interleukin-1β. This process results in a progenitor-like cell state within EGFR mutant lung alveolar type II epithelial cells that fuels tumorigenesis. Ultradeep mutational profiling of histologically normal lung tissue from 295 individuals across 3 clinical cohorts revealed oncogenic EGFR and KRAS driver mutations in 18% and 53% of healthy tissue samples, respectively. These findings collectively support a tumour-promoting role for PM2.5 air pollutants and provide impetus for public health policy initiatives to address air pollution to reduce disease burden