End User Liability for Sofware Developed with Trade Secrets

The National Conference of Commissioners on Uniform State Laws (NCCUSL) developed the Uniform Trade Secrets Act (UTSA) to unify the laws regulating the improper use of secret, economically advantageous information. However, consumers often procure software and other products without knowledge of any trade secrets used in the production of the products. Some companies have sought remedies against end users of products developed using trade secrets. But in Silvaco Data Systems v. Intel Corp., a California appeals court considering this issue in the software context held that execution of compiled object code, which is not easily interpreted by humans, is not an improper use of trade secrets embedded in the underlying, human-readable source code. This ruling implies that end users of software, and perhaps other products, are not liable for misappropriation of trade secrets merely through use of the end products. This Article surveys the application of the UTSA to software and explains why this holding is a proper reading of the Act’s scope. In addition, this Article discusses the public policies behind this limitation on liability for end users and possible implications of the Silvaco ruling beyond software

The Economics of Being Young and Poor: How Homeless Youth Survive in Neo-liberal Times

Based upon in-depth interviews with 34 youth in Halifax and seven service providers in St. John\u27s, Montreal, Hamilton, Toronto, Winnipeg, and Calgary, the findings of this study suggest that labor occurs within a particular street context and street culture. Formal and informal work can be inter-related, and despite the hardships they experience, young people who are homeless or who are at-risk of homelessness can respond to their circumstances with ingenuity, resilience and hope. Often street-involved and homeless young people are straddling formal and informal work economies while mediating layers of external and internal motivations and tensions. The reality is that the participants in this study cannot very easily engage in formal work. There is a dearth of meaningful formal work available, and when living homeless there are many challenges to overcome to maintain this work. In addition, there are few employers willing to risk hiring an individual who is without stable housing, previous employment experiences and, most likely, limited formal education. Therefore, street youth are left with informal work that provides them with survival money, basic needs, and a sense of citizenship, but which also invites belittlement, harassment, and mockery

Use of positive selection methods for discovery and improvement of nitroreductase enzymes for cancer gene therapy

Bacterial nitroreductases are members of a diverse family of oxidoreductase enzymes that are capable of activating nitroaromatic compounds, including anticancer prodrugs such as CB 1954 and PR-104A. This capability is useful in the anti-cancer gene therapy strategy known as gene-directed enzyme prodrug therapy (GDEPT), which involves the killing of tumour cells through activation of an inert prodrug to its cytotoxic form, following selective delivery of a genetically encoded prodrug-converting enzyme to cancerous tissues. A key limitation in nitroreductase-based GDEPT has been the inability to rapidly and non-invasively determine vector localisation and gene delivery prior to systemic administration of prodrug. To address this we have developed dual-purpose nitroreductases that exhibit the ability to efficiently activate both GDEPT prodrugs and next-generation radioisotope-labelled PET imaging probes, in a manner that renders the probes temporarily cell-entrapped for detection using a PET scanner. This capability places greater control of the therapy in the hands of the clinician, and will facilitate clinical development of this treatment. One key focus has been the engineering of more efficient enzymes using both random and targeted mutagenesis strategies. A complementary strategy has been the discovery of novel nitroreductases through the screening of metagenomic fragments of DNA from the unculturable bacteria present in New Zealand soil. To enable efficient screening of these libraries, we have developed an array of genetic and biochemical tools for the rapid selection of active nitroreductases. Here we have investigated the effectiveness of these different approaches for improving nitroreductase activity, and demonstrate their utility in improving activity with specific target substrates including next- generation prodrugs and PET imaging probes

Concert recording 2016-05-01b

[Track 01]. Serenade to a cuckoo / Rahsaan Roland Kirk -- [Track 02]. A quote from Clifford Brown / Rahsaan Roland Kirk -- [Track 03]. There will never be another you / Harry Warren -- [Track 04]. Bright size life / Pat Metheny -- [Track 05]. Blessed relief / Frank Zappa -- [Track 06]. All of me / Gerald Mark ; arranged by D. Holland -- [Track 07]. Sweet Georgia Brown / Bernie ; Pinkard ; arranged by D. Holland -- [Track 08]. Limehouse blues / Furber ; Braham

Dynamics of an Acute Coral Disease Outbreak Associated with the Macroalgae \u3cem\u3eDictyota\u3c/em\u3e SPP. in Dry Tortugas National Park, Florida, USA

Reports of coral disease outbreaks have increased in recent decades, but often few details are known about these outbreaks, such as environmental triggers, associated biological variables, or even the precise temporal span of the outbreak. Here we document an acute outbreak of a rapid tissue loss disease on the highest live coral cover (15%–30%) reefs within Dry Tortugas National Park, Florida, USA. This disease exhibited similar signs to white plague disease with the notable exception that a white film often was observed on the recently denuded skeleton. The temporal span of the disease was short (\u3c2 mo). Partial mortality was recorded but there was no detectable impact to overall coral cover. A significant increase and then decrease in the cover of macroalgae, primarily of the genus Dictyota, occurred simultaneously with the increase and drop in disease lesion density (number of lesions per living tissue area), respectively. No other anomalous biological or physical factors (e.g., unusual temperature, turbidity, passage of storms) corresponded with the outbreak, although it is likely that some environmental anomaly that was undetectable with the methods employed favored both disease and Dictyota expansion. This is the first study to associate a rapid increase in a macroalgal population with a coral disease outbreak. We highlight the need for increased study of the initiation of such outbreaks in the caribbean