199 research outputs found
Ontology Based Disease Information System
AbstractHuman body systems are interconnected and dependent and they canât function separately. Diseases which affect any of these systems will affect other systems as well. In existing disease diagnosis systems, diseases were classified based on different dimensions such as cause, treatment, types of diseases, etc. On the other hand the existing disease information systems are for pest control management and they cannot be extended to human diseases. In existing systems traditional database approach was used. A database provides queried information and the retrieval method is not efficient in the case of biomedical systems. The proposed system will classify the diseases into the âsystem-wise diseasesâ instead of many dimensions. The system needs careful handling of disease information. A disease information system would be appreciable instead of databases since the information systems may provide more precise and descriptive information. Therefore it is required to develop a disease information system by providing more relevant information as per the user query. The ontology based disease information system is being build and semantic based rules are designed to respond to the corresponding user query. The proposed information system is mainly focusing on improving the query results and also supports ease of use to the user
A Composite Chiral Pair of Rotational Bands in the odd-A Nucleus 135Nd
High-spin states in 135Nd were populated with the 110Pd(30Si,5n)135Nd
reaction at a 30Si bombarding energy of 133 MeV. Two Delta(I)=1 bands with
close excitation energies and the same parity were observed. These bands are
directly linked by Delta(I)=1 and Delta(I)=2 transitions. The chiral nature of
these two bands is confirmed by comparison with three-dimensional tilted axis
cranking calculations. This is the first observation of a three-quasiparticle
chiral structure and established the primarily geometric nature of this
phenomenon.Comment: 10 pages, 5 figures (1 in color), 1 table, submitted to Physics
Review Letters, written in REVTEX4 forma
High-spin structure and Band Termination in Cd
Excited states of the neutron deficient Cd nucleus have been
investigated via the Ge(Cl, p3n) reaction at beam energy of 135
MeV by use of in-beam spectroscopic methods. Gamma rays depopulating the
excited states were detected using the Gammasphere spectrometer with high-fold
-ray coincidences. A quadrupole -ray coincidence analysis
() has been used to extend the known level scheme. The positive
parity levels have been established up to and
MeV. In addition to the observation of highly-fragmented level scheme belonging
to the positive-parity sequences at E 5 MeV, the termination of a
negative-parity sequence connected by transitions has been established at
and MeV. The experimental results
corresponding to both the positive- and negative-parity sequences have been
theoretically interpreted in the framework of the core particle coupling model.
Evidence is presented for a shape change from collective prolate to
non-collective oblate above the (8011 keV) level and for a
smooth termination of the negative-parity band.Comment: 19 pages, 8 figures. Submitted to Phys. Rev.
Lifetime measurements of Triaxial Strongly Deformed bands in Tm
With the Doppler Shift Attenuation Method, quadrupole transition moments,
, were determined for the two recently proposed Triaxial Strongly Deformed
(TSD) bands in Tm. The measured moments indicate that the
deformation of these bands is larger than that of the yrast, signature
partners. However, the measured values are smaller than those predicted by
theory. This observation appears to be valid for TSD bands in several nuclei of
the regionComment: 8 pages, 5 figures. Submitted to Physical Review
Cat Swarm Optimization-Based Computer-Aided Diagnosis Model for Lung Cancer Classification in Computed Tomography Images
Lung cancer is the most significant cancer that heavily contributes to cancer-related mortality rate, due to its violent nature and late diagnosis at advanced stages. Early identification of lung cancer is essential for improving the survival rate. Various imaging modalities, including X-rays and computed tomography (CT) scans, are employed to diagnose lung cancer. Computer-aided diagnosis (CAD) models are necessary for minimizing the burden upon radiologists and enhancing detection efficiency. Currently, computer vision (CV) and deep learning (DL) models are employed to detect and classify the lung cancer in a precise manner. In this background, the current study presents a cat swarm optimization-based computer-aided diagnosis model for lung cancer classification (CSO-CADLCC) model. The proposed CHO-CADLCC technique initially pre-process the data using the Gabor filtering-based noise removal technique. Furthermore, feature extraction of the pre-processed images is performed with the help of NASNetLarge model. This model is followed by the CSO algorithm with weighted extreme learning machine (WELM) model, which is exploited for lung nodule classification. Finally, the CSO algorithm is utilized for optimal parameter tuning of the WELM model, resulting in an improved classification performance. The experimental validation of the proposed CSO-CADLCC technique was conducted against a benchmark dataset, and the results were assessed under several aspects. The experimental outcomes established the promising performance of the CSO-CADLCC approach over recent approaches under different measures
Complex ferromagnetic state and magnetocaloric effect in single crystalline Nd_{0.7}Sr_{0.3}MnO_{3}
The magnetocaloric effect in single crystalline Nd_{0.7}Sr_{0.3}MnO_{3} is
investigated by measuring the field-induced adiabatic change in temperature
which reveals a single negative peak around 130 K well below the Curie
temperature (T_C=203 K). In order to understand this unusual magnetocaloric
effect, we invoke the reported {55}^Mn spin-echo nuclear magnetic resonance,
electron magnetic resonance and polarized Raman scattering measurements on
Nd_{0.7}Sr_{0.3}MnO_{3}. We show that this effect is a manifestation of a
competition between the double exchange mechanism and correlations arising from
coupled spin and lattice degrees of freedom which results in a complex
ferromagnetic state. The critical behavior of Nd_{0.7}Sr_{0.3}MnO_{3} near
Curie temperature is investigated to study the influence of the coupled degrees
of freedom. We find a complicated behavior at low fields in which the order of
the transition could not be fixed and a second-order-like behavior at high
fields.Comment: Accepted for publication in Phys. Rev.
Low Temperature Transport and Specific Heat Studies of Nd_{1-x}Pb_{x}MnO_{3} Single Crystals
Electrical transport and specific heat properties of Nd_{1-x}Pb_{x}MnO_{3}
single crystals for 0.15 < x 0.5 have been studied in low temperature regime.
The resistivity in the ferromagnetic insulating (FMI) phase for x < 0.3 has an
activated character. The dependence of the activation gap Delta on doping x has
been determined and the critical concentration for the zero-temperature
metal-insulator transition was determined as x_{c} ~ 0.33. For a metallic
sample with x=0.42, a conventional electron-electron (e-e) scattering term
proportional T^{2} is found in the low-temperature electrical resistivity,
although the Kadowaki-Woods ratio is found to be much larger for this manganite
than for a normal metal. For a metallic sample with x=0.5, a resistivity
minimum is observed for x= 0.5. The effect is attributed to weak localization
and can be described by a negative T^{1/2} weak-localization contribution to
resistivity for a disordered three-dimensional electron system. The specific
heat data have been fitted to contributions from free electrons (gamma), spin
excitations (beta_{3/2}), lattice and a Schottky-like anomaly related to the
rare-earth magnetism of the Nd ions. The value of gamma is larger than for
normal metals, which is ascribed to magnetic ordering effects involving Nd.
Also, the Schottky-like anomaly appears broadened and weakened suggesting
inhomogeneous molecular fields at the Nd-sites.Comment: 14 pages, 8 figure
Aberrant chromatin landscape following loss of the H3.3 chaperone Daxx in haematopoietic precursors leads to Pu.1-mediated neutrophilia and inflammation
Defective silencing of retrotransposable elements has been linked to inflammageing, cancer and autoimmune diseases. However, the underlying mechanisms are only partially understood. Here we implicate the histone H3.3 chaperone Daxx, a retrotransposable element repressor inactivated in myeloid leukaemia and other neoplasms, in protection from inflammatory disease. Loss of Daxx alters the chromatin landscape, H3.3 distribution and histone marks of haematopoietic progenitors, leading to engagement of a Pu.1-dependent transcriptional programme for myelopoiesis at the expense of B-cell differentiation. This causes neutrophilia and inflammation, predisposing mice to develop an autoinflammatory skin disease. While these molecular and phenotypic perturbations are in part reverted in animals lacking both Pu.1 and Daxx, haematopoietic progenitors in these mice show unique chromatin and transcriptome alterations, suggesting an interaction between these two pathways. Overall, our findings implicate retrotransposable element silencing in haematopoiesis and suggest a cross-talk between the H3.3 loading machinery and the pioneer transcription factor Pu.1
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