Interactive dot diagram of cut-off point of the energy cost of walking.

<p>(CW = Cost of walking).</p

Model to identify a cut-off value of Energy Cost of walk (CW).

<p>The CW is the energy cost per kilogram per unit of distance covered <b>(</b>mlO₂*Kg⁻¹*min⁻¹<b>)</b>. C is the criterion. J = sensitivity (C)+specificity (C). J finding the best cut-off point that is equivalent to measuring the J of Youden Index. Youden Index is the greatest vertical distance between ROC curve and the diagonal line.</p

Demographic and clinical parameters of patients with Parkinson’s disease before and after effective AMPS and sham stimulation.

<p>Acronyms: M: male; F: female; DD: disease duration; H&Y: Hoehn and Yahr; MMSE: Mini-Mental State Examination; Side: Symtom-dominant side; LEDD: L-dopa equivalent daily dose; UPDRS: Unified Parkinson’s Disease Rating Scale; PIGD: Postural Instability Gait Disturbances</p><p>^# Data from the total group of patients (n = 11)</p><p>* Data from the group of patients eligible for fMRI analysis (n = 7).</p><p>^a Tremor sub score represents the sum of the UPDRS items in OFF condition: 3.15, 3.16, 3.17 e 3.18.</p><p>^b PIGD subscore represents the sum of the UPDRS items in OFF condition: 3.9, 3.10, 3.11, 3.12, 3.13, 3.14.</p><p>^c Rigidity subscore represents the sum of the UPDRS items in OFF condition: 3.3.</p><p>Statistically significant P-values (p < 0.05) are presented in bold.</p><p>Demographic and clinical parameters of patients with Parkinson’s disease before and after effective AMPS and sham stimulation.</p

Z-statistic images showing clusters of significantly increased RSFC (p < 0.05, cluster-level FWE corrected) after one session of effective AMPS of the primary sensory motor cortex (a), the nuclei striati (c) and the cerebellum (d), overlaid onto a MNI-registered anatomical 3D-T1 volume.

<p>Seed regions of interest are red-coloured in the panels on the left. MNI coordinates (x, y, z) of the maximal Z-scores are presented in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0137977#pone.0137977.t002" target="_blank">Table 2</a>. Coronal and axial views follow the neurological convention.</p

The device used for the AMPS treatment (a), the sites of feet stimulation (b), the effective AMPS (c), and the sham stimulation (d).

<p>The device used for the AMPS treatment (a), the sites of feet stimulation (b), the effective AMPS (c), and the sham stimulation (d).</p

Z-statistic images showing clusters of significantly increased RSFC (p < 0.05, cluster-level FWE corrected) in the effective AMPS vs. sham stimulation for the nuclei striati (a) and the cerebellum (b).

<p>Seed regions of interest are red-coloured in the panels on the left. MNI coordinates (x, y, z) of the maximal Z-scores are presented in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0137977#pone.0137977.t003" target="_blank">Table 3</a>. Coronal and axial views follow the neurological convention.</p

AMPS_Pilot_MRI data

AMPS_Pilot_MRI dat

Flowchart of the experimental protocol of the pilot interventional study as approved by the local ethical committee.

<p>Flowchart of the experimental protocol of the pilot interventional study as approved by the local ethical committee.</p