Live-streaming webcam technology in the neonatal unit: A systematic review and thematic analysis

Background: Admission of a baby for neonatal care represents a deeply traumatic time for parents. Webcam technology facilitating live-streaming of the baby when the parents are unable to be physically present has been introduced to support bonding and parental engagement in care./ Aim: This systematic review explores the impact and experiences of webcam technology upon parents of babies in the neonatal unit and neonatal health care professionals./ Study Design: A systematic search of Embase, Medline and Scopus was conducted using the keywords ‘video technology’, ‘newborn’ and ‘neonatal intensive care.’ Studies written in English and exploring live-stream technology were included. Thematic analysis per group (parents and health care professionals) was undertaken to identify similarities between themes across published studies./ Results: Ten studies were included. Six studies explored the impact of webcam technology on parents only, two on both parents and health care professionals and two on health care professionals only. Thematic analysis per group identified three themes for parents, including parental well-being, parent-infant bonding and quality of care. Two themes were identified for neonatal health care professionals, including quality of care and feasibility of webcam technology./ Conclusion: Webcam technology has many documented benefits for parental well-being. However, new technology requires adequate staff training, support and plans for ongoing maintenance. Further research is required to explore the long-term impacts on breast-milk production and infant neurological development

The fate of dendritic cells in a mouse model of liver ischemia/reperfusion injury.

Ischemia/reperfusion during liver transplantation triggers a complex cascade of inflammatory events that may lead to organ dysfunction. Herein, we investigated the consequences of hepatic ischemia/reperfusion on liver dendritic cells. Liver damage was documented by increased levels of serum alanine aminotransferase and by histopathology showing large areas of hepatocyte cytolysis. MHC class II+ CD45-B220 F4/80 dendritic cells were detected in necrotic areas 20 hours after reperfusion. Dendritic cells freshly isolated from reperfused livers displayed a mature phenotype characterized by upregulated expression of B7 costimulatory molecules; MHC-class II, and CD1d molecules. As shown by real-time PCR, IL-10, and TGF-beta mRNA accumulated in liver dendritic cells isolated after reperfusion, whereas IL-12p40 mRNA levels were decreased and IFN-gamma mRNA levels were unchanged. These results suggest that hepatic ischemia/reperfusion results in maturation of dendritic cells, which preferentially produce inhibitory cytokines.Journal ArticleResearch Support, Non-U.S. Gov'tinfo:eu-repo/semantics/publishe

sj-docx-1-msj-10.1177_13524585241229969 – Supplemental material for What contributes to disability in progressive MS? A brain and cervical cord–matched quantitative MRI study

Supplemental material, sj-docx-1-msj-10.1177_13524585241229969 for What contributes to disability in progressive MS? A brain and cervical cord–matched quantitative MRI study by Carmen Tur, Marco Battiston, Marios C Yiannakas, Sara Collorone, Alberto Calvi, Ferran Prados, Baris Kanber, Francesco Grussu, Antonio Ricciardi, Patrizia Pajak, Daniele Martinelli, Torben Schneider, Olga Ciccarelli, Rebecca S Samson and Claudia AM Gandini Wheeler-Kingshott in Multiple Sclerosis Journal</p

Cognitive rehabilitation and aerobic exercise for cognitive impairment in people with progressive multiple sclerosis (CogEx): a randomised, blinded, sham-controlled trial

Background Cognitive dysfunction in people with relapsing-remitting multiple sclerosis can improve with cognitive rehabilitation or exercise. Similar effects have not been clearly shown in people with progressive multiple sclerosis. We aimed to investigate the individual and synergistic effects of cognitive rehabilitation and exercise in patients with progressive multiple sclerosis.Methods CogEx was a randomised, sham-controlled trial completed in 11 hospital clinics, universities, and rehabilitation centres in Belgium, Canada, Denmark, Italy, UK, and USA. Patients with progressive multiple sclerosis were eligible for inclusion if they were aged 25-65 years and had an Expanded Disability Status Scale (EDSS) score of less than 7. All had impaired processing speed defined as a performance of 1 center dot 282 SD or greater below normative data on the Symbol Digit modalities Tests (SDMT). Participants were randomly assigned (1:1:1:1), using an interactive web-response system accessed online from each centre, to cognitive rehabilitation plus exercise, cognitive rehabilitation plus sham exercise, exercise plus sham cognitive rehabilitation, or sham exercise plus sham cognitive rehabilitation. The study statistician created the randomisation sequence that was stratified by centre. Participants, outcome assessors, and investigators were blinded to group allocation. The study statistician was masked to treatment during analysis only. Interventions were conducted two times per week for 12 weeks: cognitive rehabilitation used an individualised, computer-based, incremental approach to improve processing speed; sham cognitive rehabilitation consisted of internet training provided individually; the exercise intervention involved individualised aerobic training using a recumbent arm-leg stepper; and the sham exercise involved stretching and balance tasks without inducing cardiovascular strain. The primary outcome measure was processing speed measured by SDMT at 12 weeks; least squares mean differences were compared between groups using linear mixed model in all participants who had a 12-week assessment. The trial is registered with ClinicalTrials.gov, NCT03679468, and is completed.Findings Between Dec 14, 2018, and April 2, 2022, 311 people with progressive multiple sclerosis were enrolled and 284 (91%) completed the 12-week assessment (117/311 [38%] male and 194/311 [62%] female). The least squares mean group differences in SDMT at 12 weeks did not differ between groups (p=0 center dot 85). Compared with the sham cognitive rehabilitation and sham exercise group (n=67), differences were -1 center dot 30 (95% CI -3 center dot 75 to 1 center dot 16) for the cognitive rehabilitation plus exercise group (n=70); -2 center dot 78 (-5 center dot 23 to -0 center dot 33) for the sham cognitive rehabilitation plus exercise group (n=71); and -0 center dot 71 (-3 center dot 11 to 1 center dot 70) for the cognitive rehabilitation plus sham exercise group (n=76). 11 adverse events possibly related to the interventions occurred, six in the exercise plus sham cognitive rehabilitation group (pain, dizziness, and falls), two in the cognitive rehabilitation plus sham exercise group (headache and pain), two in the cognitive rehabilitation and exercise group (increased fatigue and pain), and one in the dual sham group (fall).Interpretation Combined cognitive rehabilitation plus exercise does not seem to improve processing speed in people with progressive multiple sclerosis. However, our sham interventions were not inactive.Studies comparing interventions with a non-intervention group are needed to investigate whether clinically meaningful improvements in processing speed might be attainable in people with progressive multiple sclerosis.Copyright (c) 2023 Elsevier Ltd. All rights reserved

Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

non present