Application of column buckling theory to steel aluminium foam sandwich panels

In steel structures, a lot of attention is paid to lightweight structures, i.e. reduction of dead load without compromising structural safety, integrity and performance. Thanks to modern steel aluminium foam sandwich panel manufacturing technology a new possibility became available for lightweight structural design. Assessment and understanding of the behaviour of this sandwich panel under in-plane compression or flexure is crucial before its application in steel structures. Column buckling theory is considered and applied to the steel aluminium foam sandwich panel to evaluate its behaviour under in-plane compressive load. In this work, various assumptions are made to generalise Euler’s buckling formula. The generalisation requires modification of the buckling stiffness expression to account for sandwich panel composite properties. The modified analytical expression is verified with finite element simulation employing various material models specific to steel faceplates and aluminium foam as well as various geometric imperfections. Based on this study, it can be concluded that Euler’s buckling formula can be successfully modified and used in the prediction of the load-carrying capacity of a sandwich panel

Morphological Characterization and Lumped Element Model of Graphene and Biochar Thick Films

Carbon based materials exhibit interesting mechanical, thermal and electrical properties which make them excellent contenders for use as fillers in composites as film. Graphene has been vastly used among the carbon-based materials. More recently eco-friendly carbon-based materials like biochar have emerged. The deployment of carbon-based materials in films needs to be studied since films are more versatile and permit the exploitation of electrical properties of such materials over circuits and systems. Typical circuits and systems exploiting electrical properties of novel materials perform a number of applications including sensing, detection, tunable devices and energy harvesting. In this paper, films composed of 9:1 graphene or biochar are deployed on a microstrip line. The morphological properties of graphene and biochar and their respective films are studied with Raman spectra and Field Emission Scanning Electron Microscope (FESEM). The electrical properties (four-point probe measurements and scattering parameter measurements) of the films. Low frequency measurements are used as starting point for circuit models estimating the lumped impedance of the films. From the morphological characterization it is shown that biochar films appear as granulates carbonaceous materials whereas graphene films contains several flakes forming a network. From the low frequency measurements and microwave characterization it is seen that graphene films are more conductive as compared to biochar films. In many applications, it is useful to know the surface impedance of the film since it varies on interaction with any external stimulus (variation of pressure, humidity, gas, etc.)

Supraphysiological doses of performance enhancing anabolic-androgenic steroids exert direct toxic effects on neuron-like cells

Anabolic-androgenic steroids (AAS) are lipophilic hormones often taken in excessive quantities by athletes and bodybuilders to enhance performance and increase muscle mass. AAS exert well known toxic effects on specific cell and tissue types and organ systems. The attention that androgen abuse has received lately should be used as an opportunity to educate both athletes and the general population regarding their adverse effects. Among numerous commercially available steroid hormones, very few have been specifically tested for direct neurotoxicity. We evaluated the effects of supraphysiological doses of methandienone and 17-α-methyltestosterone on sympathetic-like neuron cells. Vitality and apoptotic effects were analyzed, and immunofluorescence staining and western blot performed. In this study, we demonstrate that exposure of supraphysiological doses of methandienone and 17-α-methyltestosterone are toxic to the neuron-like differentiated pheochromocytoma cell line PC12, as confirmed by toxicity on neurite networks responding to nerve growth factor and the modulation of the survival and apoptosis-related proteins ERK, caspase-3, poly (ADP-ribose) polymerase and heat-shock protein 90. We observe, in contrast to some previous reports but in accordance with others, expression of the androgen receptor (AR) in neuron-like cells, which when inhibited mitigated the toxic effects of AAS tested, suggesting that the AR could be binding these steroid hormones to induce genomic effects. We also note elevated transcription of neuritin in treated cells, a neurotropic factor likely expressed in an attempt to resist neurotoxicity. Taken together, these results demonstrate that supraphysiological exposure to the AAS methandienone and 17-α-methyltestosterone exert neurotoxic effects by an increase in the activity of the intrinsic apoptotic pathway and alterations in neurite networks

Green-Synthesized Graphene for Supercapacitors—Modern Perspectives

Graphene is a unique nanocarbon nanostructure, which has been frequently used to form nanocomposites. Green-synthesized graphene has been focused due to environmentally friendly requirements in recent technological sectors. A very important application of green-synthesized graphene-based nanocomposite has been observed in energy storage devices. This state-of-the-art review highlights design, features, and advanced functions of polymer/green-synthesized graphene nanocomposites and their utility in supercapacitor components. Green graphene-derived nanocomposites brought about numerous revolutions in high-performance supercapacitors. The structural diversity of conjugated polymer and green graphene-based nanocomposites has facilitated the charge transportation/storage capacity, specific capacitance, capacitance retention, cyclability, and durability of supercapacitor electrodes. Moreover, the green method, graphene functionality, dispersion, and matrix–nanofiller interactions have affected supercapacitance properties and performance. Future research on innovative polymer and green graphene-derived nanocomposites may overcome design/performance-related challenging factors for technical usages

Spectral properties of quantum NN-body systems versus chaotic properties of their mean field approximations

We present numerical evidence that in a system of interacting bosons there exists a correspondence between the spectral properties of the exact quantum Hamiltonian and the dynamical chaos of the associated mean field evolution. This correspondence, analogous to the usual quantum-classical correspondence, is related to the formal parallel between the second quantization of the mean field, which generates the exact dynamics of the quantum $N$-body system, and the first quantization of classical canonical coordinates. The limit of infinite density and the thermodynamic limit are then briefly discussed.Comment: 15 pages RevTeX, 11 postscript figures included with psfig, uuencoded gz-compressed .tar fil

Plexin-B1 Activates NF-κB and IL-8 to Promote a Pro-Angiogenic Response in Endothelial Cells

The semaphorins and their receptors, the plexins, are proteins related to c-Met and the scatter factors that have been implicated in an expanding signal transduction network involving co-receptors, RhoA and Ras activation and deactivation, and phosphorylation events. Our previous work has demonstrated that Semaphorin 4D (Sema4D) acts through its receptor, Plexin-B1, on endothelial cells to promote angiogenesis in a RhoA and Akt-dependent manner. Since NF-\u3baB has been linked to promotion of angiogenesis and can be activated by Akt in some contexts, we wanted to examine NF-\u3baB in Sema4D treated cells to determine if there was biological significance for the pro-angiogenic phenotype observed in endothelium. METHODS/PRINCIPAL FINDINGS: Using RNA interference techniques, gel shifts and NF-\u3baB reporter assays, we demonstrated NF-\u3baB translocation to the nucleus in Sema4D treated endothelial cells occurring downstream of Plexin-B1. This response was necessary for endothelial cell migration and capillary tube formation and protected endothelial cells against apoptosis as well, but had no effect on cell proliferation. We dissected Plexin-B1 signaling with chimeric receptor constructs and discovered that the ability to activate NF-\u3baB was dependent upon Plexin-B1 acting through Rho and Akt, but did not involve its role as a Ras inhibitor. Indeed, inhibition of Rho by C3 toxin and Akt by LY294002 blocked Sema4D-mediated endothelial cell migration and tubulogenesis. We also observed that Sema4D treatment of endothelial cells induced production of the NF-\u3baB downstream target IL-8, a response necessary for angiogenesis. Finally, we could show through co-immunofluorescence for p65 and CD31 that Sema4D produced by tumor xenografts in nude mice activated NF-\u3baB in vessels of the tumor stroma. CONCLUSION/SIGNIFICANCE: These findings provide evidence that Sema4D/Plexin-B1-mediated NF-\u3baB activation and IL-8 production is critical in the generation a pro-angiogenic phenotype in endothelial cells and suggests a new therapeutic target for the anti-angiogenic treatment of some cancer

Extracellular vesicles shed by melanoma cells contain a modified form of H1.0 linker histone and H1.0 mRNA-binding proteins

Extracellular vesicles (EVs) are now recognized as a fundamental way for cell-to-cell horizontal transfer of properties, in both physiological and pathological conditions. Most of EV-mediated cross-talk among cells depend on the exchange of proteins, and nucleic acids, among which mRNAs, and non-coding RNAs such as different species of miRNAs. Cancer cells, in particular, use EVs to discard molecules which could be dangerous to them (for example differentiation-inducing proteins such as histone H1.0, or antitumor drugs), to transfer molecules which, after entering the surrounding cells, are able to transform their phenotype, and even to secrete factors, which allow escaping from immune surveillance. Herein we report that melanoma cells not only secrete EVs which contain a modified form of H1.0 histone, but also transport the corresponding mRNA. Given the already known role in tumorigenesis of some RNA binding proteins (RBPs), we also searched for proteins of this class in EVs. This study revealed the presence in A375 melanoma cells of at least three RBPs, with apparent MW of about 65, 45 and 38 kDa, which are able to bind H1.0 mRNA. Moreover, we purified one of these proteins, which by MALDI-TOF mass spectrometry was identified as the already known transcription factor MYEF2

Ten-Year Longitudinal Study of Thyroid Function in Children with Down's Syndrome

Background/Aims: The natural history of thyroid function in children with Down's syndrome is relatively unknown. We hypothesized that in these patients the occurrence of thyroid dysfunction rises during development. Methods: Thyroid function was assessed yearly in 145 children with Down's syndrome, all followed from birth up to 10 years of age. Heteroskedastic binary and ordinary logistic regression for repeated measures was used to evaluate the relationship of thyroid function with continuous time. Results: Congenital hypothyroidism was detected in 7% of cases. The probability of acquired thyroid dysfunction increased from 30% at birth to 49% at 10 years (p < 0.001). The subclinical hypothyroidism was nearly stable during the follow-up. The probability of hypothyroidism increased from 7 to 24% at 10 years (p < 0.001). Positive anti-thyroglobulin antibodies were associated with higher odds of more severe hypothyroidism (odds ratio 3.6). Positive anti-thyroid peroxidase antibodies were a better predictor of more severe hypothyroidism (odds ratio 6.1). Diffuse hypoechogenicity on thyroid ultrasound was found in 34 out of 145 children. Conclusion: The probability of thyroid dysfunction increasing during development is higher than previously reported. Such children should be carefully monitored annually to early identify thyroid dysfunction

Dissipative quantum mechanics and Kondo-like impurities on noncommutative two-tori

In a recent paper, by exploiting the notion of Morita equivalence for field theories on noncommutative tori and choosing rational values of the noncommutativity parameter $\theta$ (in appropriate units), a general one-to-one correspondence between the $m$-reduced conformal field theory (CFT) describing a quantum Hall fluid (QHF) at paired states fillings $\nu =\frac{m}{pm+2}$ and an Abelian noncommutative field theory (NCFT) has been established . That allowed us to add new evidence to the relationship between noncommutativity and quantum Hall fluids\cite% {ncmanybody}. On the other hand, the $m$-reduced CFT is equivalent to a system of two massless scalar bosons with a magnetic boundary interaction as introduced by Callan et al., at the so called ``magic''\ points. We are then able to describe, within such a framework, the dissipative quantum mechanics of a particle confined to a plane and subject to an external magnetic field normal to it. Here we develop such a point of view by focusing on the case $m=2$ which corresponds to a quantum Hall bilayer. The key role of a localized impurity which couples the two layers is emphasized and the effect of noncommutativity in terms of generalized magnetic translations (GMT) is fully exploited. As a result, general GMT operators are introduced, in the form of a tensor product, which act on the QHF and defect space respectively, and a comprehensive study of their rich structure is performed.Comment: 18 pages, 1 figure, accepted for publication in International Journal of Modern Physics