Response of the landscape in the Swiss Alps to the late glacial to Holocene climate transition

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Rheumatoid arthritis is associated with reduced adiposity but not with unfavorable major cardiovascular risk factor profiles and enhanced carotid atherosclerosis in black Africans from a developing population: a cross-sectional study

INTRODUCTION: Rheumatoid arthritis (RA) is characterized by inflamed joint-derived cytokine-mediated high-grade systemic inflammation that enhances cardiovascular metabolic risk and disease in developed populations. We investigated the potential impact of RA on cardiovascular risk factors including systemic inflammation and atherosclerosis, and their relationships in black Africans from a developing population. METHODS: We evaluated demographic features, adiposity indices, major traditional cardiovascular risk factors, circulating C-reactive protein and interleukin-6 concentrations and ultrasound determined carotid intima-media thickness (cIMT) in 274 black Africans; 115 had established RA. Data were analyzed in confounder-adjusted mixed regression models. RESULTS: The body mass index and waist-height ratio were lower in RA compared to non-RA subjects (29.2 (6.6) versus 33.7 (8.0), P < 0.0001 and 0.58 (0.09) versus 0.62 (0.1), P = 0.0003, respectively). Dyslipidemia was less prevalent in patients with RA (odds ratio (OR) (95% confidence interval (CI) = 0.54 (0.30 to1.00)); this disparity was no longer significant after further adjustment for reduced adiposity and chloroquine use. RA was also not associated with hypertension, current smoking and diabetes. The number of major traditional risk factors did not differ by RA status (1.1 (0.8) versus 1.2 (0.9), P = 0.7). Circulating C-reactive protein concentrations were similar and serum interleukin-6 concentrations reduced in RA (7.2 (3.1) versus 6.7 (3.1) mg/l, P = 0.7 and 3.9 (1.9) versus 6.3 (1.9) pg/ml, P < 0.0001, respectively). The cIMT was 0.700 (0.085) and 0.701 (0.111) mm in RA and non-RA subjects, respectively (P = 0.7). RA disease activity and severity parameters were consistently unrelated to systemic inflammation, despite the presence of clinically active disease in 82.6% of patients. In all participants, adiposity indices, smoking and converting angiotensin inhibitor non-use were associated with increased systemic inflammation, which related to more atherogenic lipid profiles, and circulating low density lipoprotein concentrations were associated with cIMT (partial R = 0.153, P = 0.032); RA did not impact on these relationships (interaction P ≥0.1). CONCLUSIONS: Among black Africans, patients with established RA experience reduced overall and abdominal adiposity but no enhanced major traditional risk factor and atherosclerosis burden. This study further suggests that an absent interleukin-6 release by inflamed RA joints into the circulation may account for this unaltered cardiovascular disease risk

Extrusion Production of 3D Printer Filament for Additive Manufacturing

Additive manufacturing, also known as 3D printing, is becoming a go-to production method for short production runs and rapid prototyping on a commercial scale. The growth of additive manufacturing is due to many fac­tors including development of concept modeling, product designing, prototyping, and customized parts. Pittsburg State University’s College of Technology strives to stay at the cutting edge of processing materials for additive manufacturing. The capability of making our own 3D-printer filament would allow students to work with new and different materials and would allow students to learn at the forefront of 3D printing technology. The Wayne Yellowjacket Extruder and Brabender Puller and Winder was used to produce 1.75 mm 3D-printing filament. The Yellowjacket required a lid on the hopper that was fabricated via thermoforming. The Brabender puller and winder was necessary for controlling the filament speed entering the winder and isolating the tension created by the spool from the extruder. When extruding plastic, the thickness and cross-sectional profile are dependent on the rate of cooling; therefore, a cooling trough was designed and fabricated. Polylactic acid (PLA) or acrylonitrile butadiene styrene copolymer (ABS) was used to extrude filament from this line. Successful extrusion of 3D print­ing filament will allow students to produce their own filament as needed for additive manufacturing using the existing Stratysys FDM 1600 and the student-built 3D printer