Additional file 1: of Interleukin-27: a novel biomarker in predicting bacterial infection among the critically ill

Test characteristics for predicting bacterial blood culture-positive bacterial infection. Test characteristics, including sensitivity, specificity, and positive and negative predictive values of the subset of patients defined as infection through the presence of positive bacterial blood cultures. (DOCX 12 kb

sj-tiff-1-ini-10.1177_17534259231205959 - Supplemental material for Obesity Alters cytokine signaling and gut microbiome in septic mice

Supplemental material, sj-tiff-1-ini-10.1177_17534259231205959 for Obesity Alters cytokine signaling and gut microbiome in septic mice by Lauren Bodilly, Lauren Williamson, Patrick Lahni and Matthew N. Alder, David B. Haslam, Jennifer M. Kaplan in Innate Immunity</p

Association between corticosteroids and mortality.

<p>Association between corticosteroids and mortality.</p

Association between corticosteroids and mortality based on PRISM tertiles.

<p>Association between corticosteroids and mortality based on PRISM tertiles.</p

Association between corticosteroids and complicated course (CC) based on PRISM tertiles.

<p>Association between corticosteroids and complicated course (CC) based on PRISM tertiles.</p

Clinical and demographic data for the study subjects.

<p>Clinical and demographic data for the study subjects.</p

Clinical and demographic data for the study subjects without comorbidities.

<p>Clinical and demographic data for the study subjects without comorbidities.</p

Association between corticosteroids and complicated course (CC) in subjects without comorbidities.

<p>Association between corticosteroids and complicated course (CC) in subjects without comorbidities.</p

Classification tree from the derivation cohort (N = 225).

<p>The classification tree consists of 7 biomarker-based decision rules and 14 daughter nodes. The classification tree includes day 1 and day 3 data for interleukin-8 (IL8) and C-C chemokine ligand 3 (CCL3), and day 3 data heat shock protein 70 kDa 1B (HSPA1B). Each node provides the biomarker serum concentration-based decision rule, and the number of subjects with and without complicated course (CC), with the respective rates. For consistency, the serum concentrations of all biomarkers are provided in pg/ml. Terminal nodes (TN) 1, 2, 4, and 6 are considered low risk nodes, whereas terminal nodes 3, 5, 7, and 8 are considered high-risk terminal nodes. To calculate the diagnostic test characteristics, all subjects in the low risk terminal nodes (n = 126) were classified as predicted to not have a complicated course, whereas all subjects in the high risk terminal nodes (n = 99) were classified as predicted to have a complicated course.</p

Demographics and clinical characteristics of the derivation and test cohorts.

1<p>Nineteen subjects (18 survivors and 1 non-survivor) in the test cohort did not have available PRISM scores.</p>2<p>p<0.05 vs. test cohort.</p>3<p>p<0.05 vs. respective survivors.</p>4<p>Refers to patients with immune suppression not related to cancer (for example, those receiving immune suppressive medication for solid organ or bone marrow transplantation, or those with a primary immune deficiency).</p