Kaplan Meier survival curves of low, intermediate and high-risk groups.

<p>Risk groups were defined by tertiles of risk scores of prediction models for patients with <i>de novo</i> metastatic breast cancer.</p

Study characteristics of prognostic models for metastatic breast cancer patients.

<p>Abbreviation: LDH, Lactate dehydrogenase; PS, Performance status (Zubrod/ECOG/WHO score); ALKP, alkaline phosphatase; DFI, disease free interval; KPS, Karnofsky performance score; CNS, Central nervous system; ER, Estrogen receptor; PR, Progesterone receptor; HER2, Human epidermalgrowth factor receptor 2; CTC, circulating tumor cells; RTOG, Radiation Therapy Oncology Group; RPA, recursive partitioning analysis.</p

Validation of selected models for prediction of survival of patients with <i>de novo</i> metastatic breast cancer.

a<p>Patients with brain metastases excluded.</p>b<p>Patients with equivocal Her2 status were excluded.</p>c<p>Exclusively patients with brain metastasis.</p>d<p>C-statistic for complete case analysis based on 297 patients was 0.63 (95% CI, 0.59–0.67).</p

Flow chart of study selection process. n = number of studies.

<p>Flow chart of study selection process. n =  number of studies.</p

1-, 2- and 3-year cumulative survival probability for different risk groups.

<p>Risk groups were defined by quintiles of risk scores of Williams et al.'s and Ryberg et al.'s model. 1^st quintile is the group with the highest predicted survival probability and 5^th quintile is with the lowest predicted survival probability.</p